With the help of this reliable test on human subjects, the active principle could be isolated, concentrated, and transformed into a chemically pure state by means of the newest separation methods. Two new substances, which I named psilocybin and psilocin, were thereby obtained in the form of colorless crystals.
These results were published in March 1958 in the journal Experientia, in collaboration with Professor Heim and with my colleagues Dr. A. Brack and Dr. H. Kobel, who had provided greater quantities of mushroom material for these investigations after they had essentially improved the laboratory cultivation of the mushrooms.
Some of my coworkers at the time - Drs. A. J. Frey, H. Ott, T. Petrzilka, and F. Troxler - then participated in the next steps of these investigations, the determination of the chemical structure of psilocybin and psilocin and the subsequent synthesis of these compounds, the results of which were published in the November 1958 issue of Experientia. The chemical structures of these mushroom factors deserve special attention in several respects. Psilocybin and psilocin belong, like LSD, to the indole compounds, the biologically important class of substances found in the plant and animal kingdoms. Particular chemical features common to both the mushroom substances and LSD show that psilocybin and psilocin are closely related to LSD, not only with regard to psychic effects but also to their chemical structures. Psilocybin is the phosphoric acid ester of psilocin and, as such, is the first and hitherto only phosphoric-acid-containing indole compound discovered in nature. The phosphoric acid residue does not contribute to the activity, for the phosphoric-acid-free psilocin is just as active as psilocybin, but it makes the molecule more stable. While psilocin is readily decomposed by the oxygen in air, psilocybin is a stable substance.
Psilocybin and psilocin possess a chemical structure very similar to the brain factor serotonin. As was already mentioned in the chapter on animal experiments and biological research, serotonin plays an important role in the chemistry of brain functions. The two mushroom factors, like LSD, block the effects of serotonin in pharmacological experiments on different organs. Other pharmacological properties of psilocybin and psilocin are also similar to those of LSD. The main difference consists in the quantitative activity, in animal as well as human experimentation. The average active dose of psilocybin or psilocin in human beings amounts to 10 mg (0.01 g); accordingly, these two substances are more than 100 times less active than LSD, of which 0.1 mg constitutes a strong dose. Moreover, the effects of the mushroom factors last only four to six hours, much shorter than the effects of LSD (eight to twelve hours).
--from LSD, My Problem Child by Albert Hofmann
As we returned home to Herlinda's house toward evening, Maria Sabina had already arrived there with a large company, her two lovely daughters, Apolonia and Aurora (two prospective curanderas), and a niece, all of whom brought children along with them. Whenever her child began to cry, Apolonia would offer her breast to it. The old curandero Don Aurelio also appeared, a mighty man, one-eyed, in a black-and white patterned serape (cloak). Cacao and sweet pastry were served on the veranda. I was reminded of the report from an ancient chronicle which described how chocolatl was drunk before the ingestion of teonanacatl.
After the fall of darkness, we all proceeded into the room in which the ceremony would take place. It was then locked up-that is, the door was obstructed with the only bed available. Only an emergency exit into the back garden remained unlatched for absolute necessity. It was nearly midnight when the ceremony began. Until that time the whole party lay, in darkness sleeping or awaiting the night's events, on the bast mats spread on the floor. Maria Sabina threw a piece of copal on the embers of a brazier from time to time, whereby the stuffy air in the crowded room became somewhat bearable. I had explained to the curandera through Herlinda, who was again with the party as interpreter, that one pill contained the spirit of two pairs of mushrooms. (The pills contained 5.0 mg synthetic psilocybin apiece.)
When all was ready, Maria Sabina apportioned the pills in pairs among the grown-ups present. After solemn smoking, she herself took two pairs (corresponding to 20 mg psilocybin). She gave the same dose to Don Aurelio and her daughter Apolonia, who would also serve as curandera. Aurora received one pair, as did Gordon, while my wife and Irmgard got only one pill each.
One of the children, a girl of about ten, under the guidance of Maria Sabina, had prepared for me the juice of five pairs of fresh leaves of hojas de la Pastora. I wanted to experience this drug that I had been unable to try in San Jose Tenango. The potion was said to be especially active when prepared by an innocent child. The cup with the expressed juice was likewise incensed and conjured by Maria Sabina and Don Aurelio, before it was delivered to me.
All of these preparations and the following ceremony progressed in much the same way as the consultation with the curandera Consuela Garcia in San Jose Tenango.
After the drug was apportioned and the candle on the " altar" was extinguished, we awaited the effects in the darkness.
Before a half hour had elapsed, the curandera murmured something; her daughter and Don Aurelio also became restless. Herlinda translated and explained to us what was wrong. Maria Sabina had said that the pills lacked the spirit of the mushrooms. I discussed the situation with Gordon, who lay beside me. For us it was clear that absorption of the active principle from the pills, which must first dissolve in the stomach, occurs more slowly than from the mushrooms, in which some of the active principle already becomes absorbed through the mucous membranes during chewing. But how could we give a scientific explanation under such conditions? Rather than try to explain, we decided to act. We distributed more pills. Both curanderas and the curandero each received another pair. They had now each taken a total dosage of 30 mg psilocybin.
After about another quarter of an hour, the spirit of the pills did begin to yield its effects, which lasted until the crack of dawn. The daughters, and Don Aurelio with his deep bass voice, fervently answered the prayers and singing of the curandera. Blissful, yearning moans of Apolonia and Aurora, between singing and prayer, gave the impression that the religious experience of the young women in the drug inebriation was combined with sensual-sexual feelings.
In the middle of the ceremony Maria Sabina asked for our request. Gordon inquired again after the health of his daughter and grandchild. He received the same good information as from the curandera Consuela. Mother and child were in fact well when he returned home to New York. Obviously, however, this still represents no proof of the prophetic abilities of both curanderas.
Evidently as an effect of the hojas, I found myself for some time in a state of mental sensitivity and intense experience, which, however, was not accompanied by hallucinations. Anita, Irmgard, and Gordon experienced a euphoric condition of inebriation that was influenced by the strange, mystical atmosphere. My wife was impressed by the vision of very distinct strange line patterns.
She was astonished and perplexed, later, on discovering precisely the same images in the rich ornamentation over the altar in an old church near Puebla. That was on the return trip to Mexico City, when we visited churches from colonial times. These admirable churches offer great cultural and historical interest because the Indian artists and workmen who assisted in their construction smuggled in elements of Indian style. Klaus Thomas, in his book Die kunstlich gesteuerte Seele [The artificially steered mind] (Ferdinand Enke Verlag, Stuttgart, 1970), writes about the possible influence of visions from psilocybin inebriation on Meso-American Indian art: "Surely a cultural historical comparison of the old and new creations of Indian art . . . must convince the unbiased spectator of the harmony with the images, forms and colors of a psilocybin inebriation." The Mexican character of the visions seen in my first experience with dried Psilocybe mexicana mushrooms and the drawing of Li Gelpke after a psilocybin inebriation could also point to such an association.
--from LSD, My Problem Child by Albert Hofmann
The Stropharia cubensis mushroom, if one can believe what it says in one of its moods, is a symbiote, and it desires ever deeper symbiosis with the human species. It achieved symbiosis with human society early by associating itself with domesticated cattle and through them human nomads. Like the plants men and women grew and the animals they husbanded, the mushroom was able to inculcate itself into the human family, so that where human genes went these other genes would be carried.
--from Tryptamine Hallucinogens and Consciousness by Terence McKenna (1946-2000)
In addition to being a common name for the Liberty Cap in Ireland, Pookie is an affectionate form for Pooka a well known denizen of Irish folklore. The Pooka is a mischevious shape-shifting elemental spirit able to transport humans to the fairy realm at times taking its charge on some pretty wild rides. Puck in Shakespeare's A Midsummer Night's Dream is based on the Pooka. The Liberty Cap is mentioned in Thomas Keightley's The Fairy Mythology (1850) as "those pretty small delicate fungi, with their conical heads, which are named Fairy mushrooms in Ireland, where they grow so plentifully."
