Luzindole

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Luzindole
Luzindole.svg
Systematic (IUPAC) name
N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide
Clinical data
Legal status Non-regulated
Identifiers
CAS number 117946-91-5
ATC code None
PubChem CID 122162
ChemSpider 108959
Chemical data
Formula C19H20N2O 
Mol. mass 292.375 g/mol

Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist,[1] with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor.[2][3] In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.[2][4]

References

  1. Dubocovich ML (September 1988). "Luzindole (N-0774): a novel melatonin receptor antagonist". The Journal of Pharmacology and Experimental Therapeutics 246 (3): 902–10. PMID 2843633. 
  2. 2.0 2.1 Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI (September 1998). "Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 12 (12): 1211–20. PMID 9737724. 
  3. Browning C, Beresford I, Fraser N, Giles H (March 2000). "Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors". British Journal of Pharmacology 129 (5): 877–86. PMC 1571913. PMID 10696085. doi:10.1038/sj.bjp.0703130. 
  4. Dubocovich ML, Mogilnicka E, Areso PM (July 1990). "Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test". European Journal of Pharmacology 182 (2): 313–25. PMID 2168835. doi:10.1016/0014-2999(90)90290-M. 


      
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