L-694,247

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L-694,247
200px
Properties
Molecular formula C20H21N5O3S
Molar mass 411.48 g mol-1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

L-694,247 is a somewhat selective 5-HT1D agonist, with a 10-fold greater affinity for the 5-HT1B receptor, and 25-fold greater affinity for the 5-HT1A receptor.[1] When L-694,247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.[2]

References

  1. Beer, MS (November 1993). "L-694,247: a potent 5-HT1D receptor agonist.". British Journal of Pharmacology 110 (3): 1196–200. PMC 2175804. PMID 8298808. doi:10.1111/j.1476-5381.1993.tb13941.x. Retrieved 7 January 2012. 
  2. CASTRO-e-SILVA, E. DE (August 1997). "Effect of Third Ventricle Administration of L-694,247, a Selective 5-HT1D Receptor Agonist, on Water Intake in Rats". Pharmacology, Biochemistry and Behavior 57 (4): 749–754. doi:10.1016/S0091-3057(96)00457-1. 


      
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