AL-37350A

From The Lycaeum
Jump to: navigation, search
</th></tr>
AL-37350A
140px
Systematic (IUPAC) name
(S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
Clinical data
Legal status ?
Identifiers
CAS number 362603-40-5 7pxN
ATC code ?
PubChem CID 10331436
IUPHAR ligand 160
ChemSpider 8506896 7pxY
ChEMBL CHEMBL133455 7pxY
Chemical data
Formula C14H18N2O 
Mol. mass 230.305 g/mol
 14pxN (what is this?)  (verify)

AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treament of glaucoma.[1]

See also

References

  1. May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95. PMID 12954071. doi:10.1021/jm030205t. 


      
Personal tools
Namespaces

Variants
Actions
Navigation
Forums
Lycaeum IRC Chat
TheAntiDrug Diaspora
Starting Points
Tools
Print/export