AEBSF

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AEBSF
200px
AEBSF molecule
Identifiers
CAS number 34284-75-8 7pxN
PubChem 1701
ChemSpider 1638 7pxY
DrugBank DB07347
MeSH AEBSF
ChEMBL CHEMBL1096339 7pxY
Jmol-3D images Image 1
Properties
Molecular formula C8H10FNO2S.HCl
Molar mass 239.69 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 14pxN (verify) (what is: 10pxY/10pxN?)
Infobox references

AEBSF or 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride is a water soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM.

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins (SREBP). By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

External links

  • The MEROPS online database for peptidases and their inhibitors: AEBSF
  • A Link to the ABRF group usegroup archive with an informative discussion of covalent modifications to proteins resulting from use of AEBSF: [1]
      
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