7-Methyl-α-ethyltryptamine

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7-Methyl-α-ethyltryptamine
7-Methyl-AET.png
Systematic (IUPAC) name
1-(7-methyl-1H-indol-3-yl)butan-2-amine
Clinical data
Legal status ?
Identifiers
CAS number 13712-80-6 freebase
13518-76-8 hydrochloride salt
ATC code ?
ChemSpider 26286844
Chemical data
Formula C13H18N2 
Mol. mass 202.295 g/mol

7-Methyl-α-ethyltryptamine (7-Me-αET) is a tryptamine derivative related to α-ethyltryptamine (αET). It was discovered by a team at Upjohn in the early 1960s.[1] It has similar pharmacological effects to αET, but is both 3-4 times more potent as a serotonin releasing agent, and 10 times more potent as a monoamine oxidase inhibitor,[2][3] making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and 4-MTA, which are known to be dangerous in humans when used at high doses.

See also

References

  1. U.S. Patent 3,296,072
  2. Hester, J. B.; Greig, M. E.; Anthony, W. C.; Heinzelman, R. V.; Szmuszkovicz, J. (1964). "Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives". Journal of Medicinal Chemistry 7 (3): 274. doi:10.1021/jm00333a006. 
  3. Burningham RA, Arimura GK, Yunis AA (July 1966). "Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets". Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 122 (3): 711–4. PMID 5918937. doi:10.3181/00379727-122-31233. 


      
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