5-Carboxamidotryptamine

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5-Carboxamidotryptamine
5-Carboxamidotryptamine.png
Systematic (IUPAC) name
3-(2-aminoethyl)-1H-indole-5-carboxamide
Clinical data
Legal status ?
Identifiers
CAS number 74885-09-9
ATC code ?
PubChem CID 1809
IUPHAR ligand 4
ChemSpider 1743 7pxY
ChEBI CHEBI:48292 7pxY
ChEMBL CHEMBL18840 7pxY
Chemical data
Formula C11H13N3O 
Mol. mass 203.240 g/mol
 14pxY (what is this?)  (verify)

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity.[1][2][3] It has negligible affinity for the 5-HT1E and 5-HT1F receptors.[4] 5-CT binds strongest to the 5-HT1A receptor and it was once thought to be selective for this site.[5][6]

See also

References

  1. Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). "Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.". Eur J Pharmacol. 359 (1): 81–86. PMID 9831297. doi:10.1016/S0014-2999(98)00617-7. 
  2. Wright, CE; Angus, JA (1989). "5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.". Journal of cardiovascular pharmacology 13 (4): 557–64. PMID 2470992. 
  3. Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Archived from the original on 21 April 2008. Retrieved 2008-04-11. 
  4. Stanton JA, Middlemiss DN, Beer MS. (1996). "Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.". Neuropharmacology. 35 (2): 223–229. PMID 8734492. doi:10.1016/0028-3908(95)00178-6. 
  5. Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). "5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors". British Journal of Pharmacology 128 (1): 158–64. PMC 1571602. PMID 10498847. doi:10.1038/sj.bjp.0702759. 
  6. Saxena, PR; Lawang, A (1985). "A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors". Archives internationales de pharmacodynamie et de therapie 277 (2): 235–52. PMID 2933009. 


      
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