4-Fluoro-5-methoxy-DMT

From The Lycaeum
Jump to: navigation, search
</th></tr>
4-Fluoro-5-methoxy-DMT
File:4-Fluoro-5-methoxy-N,N-dimethyltryptamine.svg
Systematic (IUPAC) name
4-Fluoro-5-Methoxy-N,N-dimethyltryptamine
Clinical data
Legal status ?
Identifiers
CAS number 312314-18-4
ATC code ?
Chemical data
Formula C13H17FN2O 
Mol. mass 236,13 g/mol
 14pxY (what is this?)  (verify)

4-Fluoro-5-Methoxy-N,N-dimethyltryptamine (4-F-5-MeO-DMT) was first described by David E. Nichols team in 2000. It is a potent 5-HT1A agonist. Substitution with the 4-fluorine markedly increased 5-HT1A selectivity over 5-HT2A/2C receptors with potency greater than that of the 5-HT1A agonist 8-OH-DPAT.[1]

The analog compound with the N,N-dialkyl substituents constrained into a pyrrolidine ring, is a slightly stronger agonist for the 5-HT1A receptor and retains the selectivity over the 5-HT2A/2C receptors.[2]

See also

References

  1. Joseph B. Blair, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka, Medhane G. Cumbay, Val J. Watts, Eric L. Barker, and David E. Nichols (2000). "Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines". Journal of Medicinal Chemistry 43 (24): 4701–4710. PMID 11101361. doi:10.1021/jm000339w. 
  2. Uros Laban, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka and David E. Nichols (2001). "A Novel Fluorinated Tryptamine with Highly Potent Serotonin 5-HT1A Receptor Agonist Properties". Bioorganic & Medicinal Chemistry Letters 11 (6): 793–795. PMID 11277522. doi:10.1016/S0960-894X(01)00062-2. 
      
Personal tools
Namespaces

Variants
Actions
Navigation
Forums
Lycaeum IRC Chat
TheAntiDrug Diaspora
Starting Points
Tools