Rings with nitrogen in them...

Piperazine explorations

Substances: BZP, TFMPP

slight effects - mild trippyness: this is not a placebo, but that is pretty much all I know. Out in two or three hours.

100mg oral:

Alert after 25 or so minutes, peak from t+1h to t+2.5 hours or so -- then fades out. Trippy mind-set, freely floating thought. Clear presence of CEVs - pretty, yet unspectacular. It is not "good" or "bad": A very un-emotional trip. It's there and that's that.

100mg oral plus 200mg BZP oral:

a) We had to deliver our cat to friends who would take care for her over a week we were going to be gone. The substances were ingested before leaving for the metro, and 25 minutes later, sitting in the station I felt quite intoxicated and wondered whether I'd make the train-ride. I peaked pretty much somewhere during the metro-ride. Interestingly my stomach settled quite well - maybe because I was sitting orthogonal to the riding-direction, maybe because I was concentrating on the cat which was frightened in her carrier-box. The prospect of encountering so many people in a very disorganized mind-state would've been frightening without my straight partner around. Later at the friends house, perfectly fine conversations (none of the scatterbrain that acid gives me). Quite social: clear urge to communicate and connect. Quite an insomnia-tail. No appetite all day, and none the next day either.

b) At about t+30min I decided to distract myself from my stomach that felt just as upset as last time. Went furniture-shopping. Clear appreciation for the different textures and "feels" of the sofas and the different materials used to make the bureaus we looked at. Again, clearly enhanced openness, urge to communicate and connect, lowered inhibitions to say things that may sound strange. At t+1.5h, went back home to drink some ginger-tea which helped me overcome the remaining twinges of nausea. Spent the rest of the day wandering through the nearby park which helped getting me physically exhausted and thereby alleviated the insomnia-tail a little.

Muscle-stiffness in both experiences (a) and (b), felt more strongly the first time when I couldn't move around. This would do well for dancing or similar physical activity.

200mg BZP alone:

As one would have expected: the same empathic and social feeling minus the visuals which apparently came more from the TFMPP. Active, communicative, considerably less nausea. Less of a perception that I'm "tripping", which I am very aware of when on TFMPP alone. Tricky, since this seems to alter my behaviour more than TFMPP.

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I understand that TFMPP is a slightly 5-HT[1B] selective partial agonist, with similar potency at 5-HT[1A] and 5-HT[2C] receptors. BZP seems to be a 5HT[3] agonist only.

There's something interesting here but I can't put my finger on it...

Baxter et al (1995)
5-HT2 receptor subtypes: A family reunited? TiPS 16 105.

Glennon R.A., et al (1988)
Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands. J.Med.Chem. 31 1988.

Glennon, R.A., et al. (1989)
Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study. Eur. J. Pharm. 168: 387-392.

Another interesting reference:

Hoyer, D. (1988)
Functional correlates of serotonin 5-HT1 recognition sites. J. Recept. Res. 8: 59-81

... goes in the direction I had been thinking of in an earlier post: 4-Phenylpiperidine, 1-(2-Pyrimidinyl)piperazine, 1-naphtyl-Piperazine...

Why would these double-ring systems have any effect on 5HT receptors at all? And why selectively? There seems to be a large number of interesting substances out there and it is completely nebulous to me what mechanism they derive their activity from...