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Sulfurous Samadhi - An Investigation of 2C-T-2 & 2C-T-7, by Murple

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Sulfurous Samadhi
An Investigation of 2C-T-2 & 2C-T-7
by Murple, Feb 6, 2001
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Table of Contents

  • Introduction
  • Chemistry and Physical Properties
  • History
    • Discovery
    • Early Research
    • 2C-T-2 In The Netherlands
    • Blue Mystic
    • Getting Attention
    • The Black Market
    • Incidents
    • Moving On
  • Research
    • Stolaroff's & Well's Study
    • Casey Hardison's Survey
    • 2C-T-2 and 2C-T-7 User Surveys
      • Demographics
      • Medical Conditions
      • Routes of Ingestion
      • Dosages
      • Usage Patterns
      • Willingness to Repeat
      • Side Effects
      • Drug Combinations
      • Aftereffects
      • Quality Over Time
      • Long Term Effects
  • Pharmacology
    • Effects
    • Aftereffects
    • Dosage and Routes
    • Receptor Affinities
    • Metabolism
    • Tolerance
    • Contraindications
    • Drug Interactions
  • Legal Status
    • Australia
    • Canada
    • Germany
    • The Netherlands
    • Sweden
    • United Kingdom
    • United States
  • Conclusion
  • Appendix 1: User Quotes
    • 2C-T-2
    • 2C-T-7
    • 2C-T-2 vs. 2C-T-7
  • Appendix 2: Syntheses
    • 2C-T-2
    • 2C-T-7
  • Appendix 3: Product Literature
    • 2C-T-2 Flier
    • Blue Mystic Flier, Version 1
    • Blue Mystic Flier, Version 2
    • Blue Mystic Shopkeeper Information
  • Bibliography

 

 

 

Introduction



I first heard of 2C-T-2 in the summer of 1998, when I began to hear stories about a new 2C-B replacement being sold by smartshops in the Netherlands. PIHKAL deepened my interest. I began looking around and found several online companies based in the Netherlands and Sweden selling the pills, but none were willing to ship to the United States, citing as a reason that that the drug is illegal in the United States. Frustrated, and realizing that 2C-T-2 is not in fact scheduled in the United States (although the analogue laws most likely apply), I kept looking. Several months later, I found a smartshop willing to sell to Americans. I immediately ordered several doses.

My first time taking the drug was on Easter, April 4, 1999. I had not intended to take 2C-T-2 that day, instead taking some mescaline in the form of cactus extract. Several hours later I decided that the cactus was not sufficiently potent and that I was not where I wanted to be. I decided to take one 8mg pill of 2C-T-2. I soon reached a wonderful space which was for the most part like a mild to moderate mescaline trip. I was incredibly excited to have found a mescaline-like psychedelic which was legally obtainable which produced a trip of a nice manageable duration. Best of all, there was no horrible green slime to drink!

A couple weeks later, on April 17, I had my first full exposure to 2C-T-2. Along with a friend, I took three pills for a dose of 24mg. We soon found ourselves in the midst of incredibly visual and bizzarre trips. My friend lay on the couch nearly unresponsive, lost in his own internal world. I roamed my apartment watching inanimate objects dance with new life. After several hours, I found myself on the other side of a magical experience. This drug had surpassed all expectations - very impressive!

I tried 2C-T-2 several times after that, including combinations with MDMA and 2C-B. I was very upset a few months later when it was announced that it had been made illegal in the Netherlands and would no longer be sold.

When 2C-T-7 became commercially available at the end of 1999, I was overjoyed. I promptly purchased some and tried it twice within a month. It too was very impressive, although I preferred 2C-T-2 slightly, mostly due to its shorter duration. Soon thereafter, 2C-T-2 became commercially available once again from new sources. Although nowadays I virtually never have the opportunity to use psychedelics, and although it has been over a year since my experiments with 2C-T-7, both of these chemicals continue to fascinate me.

Within a few months of becoming available, I began to notice a rapid growth in the popularity of 2C-T-7. Out of an concern about widespread use of such obscure drugs, fueled in part by a desire to look after my own personal safety, I decided to try and gather all the information available about both of these drugs. I began collecting first hand reports, looking for scientific research, and contacting experts in the field. It didn't take long to realize that there was very little information to collect. Other than PIHKAL, a handful of first hand reports, and a few minor mentions in various publications, there was nothing.

In the months since then, working on this paper has been a fascinating project. I have communicated with many fascinating people, from scientists to smartshop employees, from users to British government employees. I have read everything from previously unpublished scientific notes to barely intelligible trip reports from dangerously ignorant people. I have had the joy of hearing about powerfully positive life-changing experiences from both drugs, and I have had the sadness of having to break the story of the first death involving 2C-T-7.

There were many dark times when I was deeply disturbed and saddened by some of the reckless use many recreational users engaged in. For several months before the death of Jake Duroy, there was a disturbing lack of respect for these drugs. In spite of repeated warnings from more experienced users that these are new and unstudied drugs, many users carelessly took massive doses of the drug. Reports of accidental overdoses and overwhelming bad trips began appearing on the Internet. Reports of people selling 2C-T-7 at raves and concerts, sometimes representing it as other drugs, began to appear. Ever since the early days of mescaline research, people have debated if and how access to psychedelic drugs should be controlled, and this issue has come up often in connection to 2C-T-2, 2C-T-7 and other exotic drugs. With time and experience, especially after the the death of Jake Duroy, the situation with these drugs gradually began to turn around. People began to respect the nature of these drugs a little more, and became a little less gung-ho in their use.

The darker episodes in my research are easily made up for by all the benefit I have seen people derive from using these two drugs, and the benefits I hope this paper will provide. When used wisely, these drugs are powerful tools for personal growth. This paper collects for the first time all the published knowledge we now have about these drugs. In addition, this paper presents months worth of new research into the history, effects and risks of both chemicals, including surveys of nearly five hundred users and previously unpublished historical information. Furthermore, I have presented quite a few theories and ideas which have occured to me during my research. Hopefully, this material will grab the attention of researchers who can try to fill in the many gaps in our knowledge. My hope is that this paper will dispell many of the rumors about these drugs and enable people who decide to use them to do so in a manner that is not only safe but which increases their chances of having a positive and rewarding experience.

-- Murple
-- February 3, 2001


Acknowledgements

Thanks to Kaya and Rollie, co-travellers and friends. Thanks to Sasha Shulgin for his research and for his assistance in collecting data for this project. Thanks to the staff of Erowid for allowing me to run my survey on their servers, and for their invaluable proofreading and critiquing services. Thanks also to the staff of the Lycaeum for helping spread the word about the user surveys. Thanks to the staffs of De Sjamaan and Conscious Dreams for their crucial help in assembling the history of these drugs. Thanks to the hundreds of people who responded to surveys or contributed trip reports or information. Thanks and condolences to the friends of Jake Duroy who took the time during their grief to help document what happened, so that others could learn from it and future deaths be prevented. Thanks to all the researchers before me who laid the foundations that made this paper possible. And last but certainly not least, thanks to the countless people who take the time to help others be safe, working for legal reform, spreading accurate information about drugs and fighting misinformation in the face of oppression and ignorance.

 

 

 

Chemistry and Physical Properties



2C-T-2 and 2C-T-7 are two closely related chemicals in a series of phenethylamine compounds created by Alexander Shulgin. The 2C prefix derives from the fact that these compounds are the two carbon phenethylamine homologues of previously made three carbon amphetamines, having the alpha-methyl group removed. Shulgin named most of the 2C compounds by adding the last letter of the amphetamine prototype's name, for example 2C-B from DOB and 2C-I from DOI. The 2C-T series is based on the three carbon ALEPH series (described in detail in Shulgin's book, PIHKAL), and the T comes from the fact that the original name for ALEPH-1 was DOT (T standing for "thio", from it's sulfur atom). There are a whole series of 2C-T compounds which have been made or theorized, and the numbering of the series was assigned in the order the chemicals were thought up, rather than due to any structural properties.

2C-T-2

2C-T-7

So far, the only syntheses which have been published are Shulgin's methods as described in PIHKAL. Shulgin's recipes for 2C-T-2 and 2C-T-7 have been included as appendices to this paper.

Physical Properties

2C-T-2's full name is 2,5-dimethoxy-4-ethylthiophenthylamine, and 2C-T-7's is 2,5-dimethoxy-4-(n)-propylthiophenethylamine. Both chemicals generally come in the form of a hydrochloride salt, which are white crystalline powders. As free bases, both chemicals are a clear white oil. 2C-T-2 has the molecular formula C12H19NO2S and a molecular weight of 241.3476. 2C-T-7, has the molecular formula C13H21NO2S and its molecular weight is 255.3744. 2C-T-2 has a boiling point of 120-130° Celsius (at 300 microns). 2C-T-7 has a boiling point of 140-150° Celsius at 251 microns.

Both chemicals react to Marquis reagent, the principal ingredient in ecstasy testing kits, by producing an orange-red color reaction (similar to the color of uncooked salmon). 2C-T-2 produces a slightly more orange color, and 2C-T-7 a slightly more red color, but the difference is minute.

Regarding the stability of these chemicals, in 2000, Shulgin re-examined the original discovery samples of 2C-T-7 and the closely related 2C-T-4, to make sure that the propyl and isopropyl groups, respectively, had not been compromised. These samples were at the time well into their second decade. Both samples were still white, and the spectra showed clean when checked by mass spectroscopy. When asked about the possibility of long term storage of 2C-T-2 and 2C-T-7, he said "I feel that the solids are stable with time." It is probably advisable to store the chemicals in air-tight, light-proof containers (such as amber glass vials with good caps) in a cool, dry location.

Since these chemicals have become more widely available, some people have been dissolving them in solvents to allow for measuring doses out by liquid volume. The two most popular solvents for this purpose have been water and ethyl alcohol. There have been mixed reports as to the solubility of 2C-T-2 and 2C-T-7. Some have reported that when making solutions using water, with time, the drugs recrystallize and settle to the bottom. Reports of both unexpectedly strong and weak reactions raise questions about just how soluble these chemicals are. One factor which needs to be accounted for as well is that the solvents being used are not pure. Although advocates of this measurement technique recommend using distilled water, it is possible that people are also using plain bottled water and even unfiltered tap water. Some people use high proof liquor such as vodka or grain alcohol as a solvent. This offers the advantage of protecting against biological contaminants, and appears to offer somewhat better solubility. Regardless of which solvent is used, the impurities present in both liquor and water could conceivably alter the ability of the phenethylamines to enter and remain in solution, and could potentially react with them chemically. Another factor which could alter the ability of the chemicals to remain in solution is the temperature at which the solution is stored. Solutions which are stable at room temperature may separate out if stored in the refrigerator. The long term molecular stability of 2C-T-2 and 2C-T-7 in solution has never been explored, and there is the possibility that they may be less stable when stored in solution versus being stored in pure form.

Related Chemicals

Shulgin has thought up and named twenty-four compounds in the 2C-T series of phenethylamines. Nine of these have been synthesized and evaluated up to active doses, two have been synthesized but have not had their activities discovered, and the rest have never been made. There is also a twenty-fifth chemical in this series which not only was never made, but never officially assigned a 2C-T-X code name.

2C-T 5-dimethoxy-4-methylthiophenethylamine
The original compound in the series. It is a psychedelic described by Shulgin as "generic" in dosages of 60 to 100mg. In contrast to this evaluation, one person interviewed while collecting 2C-T-2 and 2C-T-7 experience reports for this paper mentioned having used this drug as well. He said "I actually prefer 2-CT despite it's lower potency (100mg) because it doesn't seem to engage your mind as much - like DMT, it's just watch the fireworks." Having tried several drugs in the 2C-T series, he observes, "As the aliphatic chain gets longer the effects seem to become less visual and more mind-manifesting (in the sense that thought processes become more important. For instance 2-CT can be floridly visual with patterns and color changes similar to mescaline, whereas 2-CT-7 is rarely very visual with some exceptions (colors get brighter, contrast is accented))." He also stated that his partner got more nausea from 2C-T than other drugs in this series, but pointed out that "she has a pretty sensitive stomach." While the low potency is a negative, it has the advantage of producing a short trip of only 3 to 5 hours.
2C-T-2 2,5-dimethoxy-4-ethylthiophenethylamine
As a principal subject of this paper, this drug will be discussed elsewhere.
2C-T-3 2,5-dimethoxy-4-(beta-methallylthio)phenethylamine
Has never been synthesized.
2C-T-4 2,5-dimethoxy-4-isopropylthiophenethylamine
An active psychedelic at dosages of 8 to 20mg and results in a long 12 to 18 hour trip. It apparently produces some cross-tolerance with 2C-B. An entire chapter of Shulgin's PIHKAL is devoted to a detailed description of a powerful experience of a 2C-T-4 trip.
2C-T-5 2,5-dimethoxy-4-cyclohexylthiophenethylamine
Has never been synthesized.
2C-T-6 2,5-dimethoxy-4-phenylthiophenethylamine
Has never been synthesized.
2C-T-7 2,5-dimethoxy-4-(n)-propylthiophenethylamine
As a principal subject of this paper, this drug will be discussed elsewhere.
2C-T-8 2,5-dimethoxy-4-cyclopropylmethylthiophenethylamine
Active in the 30-50mg dose range, giving a 12 to 18 hour trip which Shulgin describes by saying "there are as many negatives as there are positives."
2C-T-9 2,5-dimethoxy-4-(t)-butylthiophenethylamine
Active in the 60 to 100mg dose range, and gives effects lasting 12 to 18 hours. With this one, heavy body load seems to dominate over the mild psychedelic effects.
2C-T-10 2,5-dimethoxy-4-(2-pyridylthio)phenethylamine
Synthesis was abandoned before completion.
2C-T-11 2,5-dimethoxy-4-(4-bromophenylthio)phenethylamine
Synthesis was abandoned before completion.
2C-T-12 2,5-dimethoxy-4-(1-morpholinothio)phenethylamine
Synthesis was abandoned before completion.
2C-T-13 2,5-dimethoxy-4-(2-methoxyethylthio)phenethylamine
A psychedelic at 25 to 40mg, giving a 6 to 8 hour trip. In the paper "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs" by Alexander Shulgin and Peyton Jacob III, this compound was erroneously listed in as 2C-T-24. When asked about this, Shulgin said that this is simply a misprint.
2C-T-14 2,5-dimethoxy-4-(2-methylthioethylthio)phenethylamine
Has been synthesized but, no human testing has been done, and its activity is unknown.
2C-T-15 2,5-dimethoxy-4-cyclopropylthiophenethylamine
Has been synthesized and preliminary tests have been done, with some threshold effects lasting several hours being noted from 6-30mg. Its activity remains unknown. It has been given the nickname "Sesqui" by Shulgin, derived from the fact that 15-carbon terpenes are known by the term "sesquiterpene," and this is the fifteenth drug in the 2C-T series.
2C-T-16 2,5-dimethoxy-4-allylthiophenethylamine
Has never been synthesized.
2C-T-17 2,5-dimethoxy-4-(s)-butylthiophenethylamine
Produces a 10 to 15 hour psychedelic trip without significant sensory changes when taken in dosages of 60 to 100mg. Shulgin has given this compound the nickname "Nimitz" - a name derived from State Highway 17 in California (now Interstate 880), known as the Nimitz Freeway.
2C-T-18 2,5-dimethoxy-4-cyclobutylthiophenethylamine
Synthesis was abandoned before completion.
2C-T-19 2,5-dimethoxy-4-(n-butylthio)phenethylamine
Synthesis was abandoned before completion.
2C-T-20 2,5-dimethoxy-4-(beta-methallylthio)phenethylamine
This is another name for 2C-T-3. The reason for this is that the homologous three carbon amphetamine (ALEPH-3) had been started, abandoned, and forgotten about. Several years later, Shulgin decided to try making the three carbon homologue again, and assigned a new number to the forgotten project. A new number was assigned to the corresponding 2C-T as well, before remembering the original ALEPH-3 project. As noted above, it has never been synthesized.
2C-T-21 2,5-dimethoxy-4-(2-fluoroethylthio)phenethylamine
In doses from 8 to 12mg, is a mild psychedelic without much body load that lasts 7 to 10 hours. In "Thanatos to Eros," Myron Stolaroff describes this drug as being a "wonderful energizer" rather than a psychedelic, saying that it "raises mood and spirit, raises the energy level, increases wit and sense of humor, facilitates communication, and in general provides an excellent good time." The anonymous contributor mentioned above under 2C-T said of 2C-T-21 that it is "perhaps one of the best," and that it "allows you to do just about anything while feeling emotionally open and motivated." More to the point was his closing remark on it, "Amazing stuff!" One other interesting bit of trivia about this drug is that it was the first psychedelic drug synthesized which contained six separate elements (C, H, N, O, S, and F). This was the last drug in the 2C-T series to be synthesized and investigated.
2C-T-21.5 2,5-dimethoxy-4-(2,2-difluoroethylthio)phenethylamine
A humorously named compound thought up while writing PIHKAL. Although it has not been synthesized, Shulgin writes "I will wager mucho that it will be very potent."
2C-T-22 2,5-dimethoxy-4-(2,2,2-trifluoroethylthio)phenethylamine
Synthesis was abandoned before completion.
2C-T-23 2,5-dimethoxy-4-cyclopentylthiophenethylamine
Synthesis was abandoned before completion.
2C-T-24 2,5-dimethoxy-4-diethylaminothiophenethylamine
In addition to the named 2C-T compounds, Shulgin also wrote about this chemical in PIHKAL. It has been theorized by never synthesized. Although never officially named so by its inventor, it seems logical to assign the name 2C-T-24 to this compound, in case it ever gets synthesized and explored and needs to be referred to by a simpler name.

After all this, Shulgin decided that while the 2C-T family of drugs was pharmacologically interesting, it no longer seemed too challenging from a creative chemistry perspective. Realizing that others could pick up with them where he left off, using the knowledge in PIHKAL, he abandoned further research with the 2C-T series. Information gleaned from this research went on to bear other interesting fruit, however. Seduced by the unexpected enhancement of activity achieved by substituting sulfur for oxygen, Shulgin turned his attention back to mescaline and its derivatives escaline and meta-escaline. He spent several months synthesizing sulfur analogues of these, a process culminating in the creation and evaluation of all five possible compounds. The results were positive. 3-Thioescaline (3-TE) was found active in the 60 to 80mg range, and 4-TE in the 20 to 30mg range. 3-Thio-meta-escaline (3-TME) as well as 4-TME were both found active in the range of 60 to 100mg. 5-TME has been run up to 200mg, and if it is active, the dosage must be higher than this. Including an ethoxy group into the mescaline molecule and then inserting a sulfur atom was found to be able to increase the potency up to twenty times that of mescaline (as in the case of 4-TE). Further offspring of this line of research can be found in PIHKAL, including thioproscaline (which exhibited some unpleasant effects) and 4-thiobuscaline (which appears to be primarily a euphoriant). Shulgin then went on to explore this ethoxy/thio substitution in the tryptamine world, documenting some of his finds in TIHKAL.

Regarding further explorations of the 2C-T series: if anyone has continued this research as Shulgin hoped, the results have not been made publically available. This field is ripe for picking.

 

 

 


History


Discovery

The history of these two compounds begins in 1981, when sometime between July 28 and August 20 (the exact date is unknown), Alexander Shulgin first synthesized 2C-T-2. The first human trial of this drug took place at 10:50AM on the morning of August 20 of that year, when Shulgin took 5mg. After an hour, no effects were noted, so he took another 5mg. Within 10 minutes, effects became apparent, and Shulgin reached a +1 level experience, meaning a real and unmistakable effect of measurable duration is felt, but its nature is not clear. The next trial took place soon after, at 10:10 in the morning on September 2, when Shulgin took 15mg, and reached a +2 level experience, meaning that the nature of the drug is clear, but the effects could still be mostly suppressed if required, such as to handle an emergency situation. Several weeks later, on October 24, Shulgin and his wife Ann each took 18mg at 4:50PM, which led to what he describes as "a fine +++ with much energy and no apparent price to pay -- it was excellent but there were hints of dark corners" (a +3 indicates that the full potential of the drug's effects have been reached). On December 5, 1981, Shulgin took 2C-T-2 to his research group for its first group trial, where 9 people assayed it in dosages from 12 to 16mg Later group trials ran the dosage level up to well over 20mg, and in the end it was decided to state 2C-T-2's dosage range to be 12-25mg.

A few years later, 2C-T-7 was first synthesized. At 9:25 on the morning of January 16, 1986, Shulgin performed the first human test of this drug with a 2mg dose. No effects were noted, nor were any noted with a 4mg trial several days later. Between February and May of that year, Shulgin conducted further bioassays, having several effective trials with 20-25mg doses, most reaching the +3 level. On October 16, 1986, a small group experiment was conduced with 2C-T-7 to check the drug's effect on the cardiovascular system. Most subjects had a slight rise in both systolic and diastolic pressure between the second and fourth hours, and all were back to normal (and even below normal in a few cases) by the tenth hour. On September 28, Shulgin first presented 2C-T-7 to his research group.

Early Research

After their discovery and the initial explorations into their effects, these drugs languished in obscurity for several years. They were first introduced to the public with the 1991 publication of Alexander Shulgin's book PIHKAL which not only described their effects but described how to synthesize them, making them available for independent researchers to investigate them.

Among these early pioneers were Myron J. Stolaroff and Charles W. Wells, who in 1993 published a paper which summarized a series of experiments designed to compare the therapeutic potential of 2C-T-2 and 2C-T-7 to MDMA. In this study, subjects who had not tried any of the three drugs were given one of the drugs and later asked to fill out a survey on the experience. The results of this study found that 2C-T-2 and 2C-T-7 have significant therapeutic potential, and in fact, they have been used in psychedelic therapy, often as a follow-up to a dose of MDMA. The results of this study will be discussed in more detail elsewhere in this paper. Stolaroff also discusses his work with 2C-T-2, 2C-T-7 and several other drugs in the 2C-T series in his 1994 book Thanatos to Eros: Thirty-Five Years of Psychedelic Exploration.

The next mention of these drugs in publication was in the 1994 paper "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs" by Peyton Jacob III and Alexander Shulgin. This paper did not focus very strongly on 2C-T-2 or 2C-T-7 however.

2C-T-2 In The Netherlands

A turning point in the history of these drugs occurred in November of 1997, when pills alleged to be 2C-T-7 began to appear in the so-called "smartshops" in the Netherlands. These are stores which usually sell items such as peyote cacti, psilocybin mushrooms, and various herbal drugs as well as nutritional supplements. In the beginning, many smartshops were selling these pills. At one point, the Dutch police apparently confiscated these pills from several smartshops, but later returned the merchandise with approval to sell it.

 

One shop, De Sjamaan, had the pills analyzed by a lab after their test group had tried them and found the effects to be different from the results they expected based upon reports they had read. They found out that the pills were in fact 2C-T-2 which was being misrepresented. According to one version of the story, the wholesaler of the pills was misrepresenting them out of a desire to put off the authorities and keep 2C-T-2 legal. Another version says that the wholesaler honestly thought they had 2C-T-7 and that it had been misrepresented to them by the manufacturer. In either case, after getting the lab results, De Sjamaan and other stores began to market the tablets under their proper identity. Other sources interviewed for this article were skeptical of De Sjamaan's claims to have tested the pills, due to difficulty in getting such tests done, and claim that they continued to be sold everywhere as 2C-T-7 for several more months, until a different company did an analysis on the pills. On the other hand, a 2C-T-2 report by Horus states "2C-T-2 has been sold in the Dutch smartshops from November 1997 until now," which lends credence to the notion that it was being sold under its proper name at this time.

The wholesaler of the tablets approached another smartshop, Conscious Dreams, in early 1998 offering to sell them 2C-T-7. Being suspicious about the identity of the pills, due to the difficulties involved in making 2C-T-7, they also decided to have the pills sent to a lab for analysis. This turned out to be a difficult task, as many of the labs they went to, including the government's criminology lab, did not have reference standards for 2C-T-7. Finally a sympathetic university professor was found who was willing and able to do the analysis. At this point VLOS, which is an organization of smartshops headed by a 5 member board (one of whom at the time was a Conscious Dreams employee), was against the marketing of these pills because the actual ingredients were not yet known and therefore there were concerns over their safety.

On April 20, 1998, Conscious Dreams got their lab results back, finding that the pills were in fact 2C-T-2. They issued an announcement that the 2C-T-7 pills were in fact 2C-T-2, that they were pure, and that they had been offered and had bought the distribution rights to the material. After taking care of packaging and promotional concerns, they began marketing 2C-T-2 in May of 1998. Promotional posters, information fliers, and product packaging all bore a design of blue dots and white lattice-work over a florescent orange background, designed by Donald Beekman Studio. An English translation of the informational flier incorrectly called 2C-T-2 an amphetamine, but this error is not present on the Dutch version of the flier.

 

Despite the fact that Conscious Dreams purchased sole distribution rights to 2C-T-2, the wholesaler apparently continued selling the material to other companies. In addition, De Sjamaan was independently obtaining 2C-T-2, and a price war between them and Conscious Dreams broke out. Conscious Dreams, interestingly, denies that such a price war ever occurred. Perhaps this can be explained by the fact that Conscious Dreams was at the time a much larger company, and it's possible that while De Sjamaan felt competition from the larger Conscious Dreams, the sales volume of the smaller company was not enough that their price cuts were even noticed by the larger.

 

July of 1998, Conscious Dreams was selling 2C-T-2 in packages of two 8mg tablets for 25 guilders, which at the time was approximately $12.50 (US). After several months, this was changed to three tablets for 30 guilders. In addition to selling 2C-T-2 retail through their own shops, Conscious Dreams also sold the pills wholesale to other smartshops through the distributorship branch of the company. De Sjamaan was selling 3 tablets for 25 guilders. Prices at other smartshops varied. Tambu Passionstore in Rotterdam was selling 3 tablets for $18.00 (US). A July 13 promotional email sent out by another smartshop, The Gate (based in Amerongen) read:

2C.T.2    2,5 DIMETHOXY-4-ETHYLTHIOPHENETHYLAMINE

2C.T.2 IS SPEEDY AND TRIPPY 
 
2C.T.2 is sold in 2 pieces at once!

We sell 2 pieces for $25 USD. 

For bulk orders:
10 - 40 pieces: $11 USD a piece
41 - 60 pieces: $10 USD a piece
61 - 80 pieces: $9   USD a piece
81 - or more     $8   USD a piece

The shipping costs are: $5 no matter the amount of pieces.

Send your order with cash $ USD to:

The Gate
P.O. BOX 59
3958 ZV Amerongen
Holland

Another curious situation arose from the earlier confusion as to the identity of the drug in the pills. Even after lab analyses had been done, and after statements had been issued about the true identity of the pills, some shops continued to sell the pills as 2C-T-7. In some cases, these shops would be selling identical pills as both 2C-T-2 and 2C-T-7, side by side, oblivious to the fact that they were both the same pills. And as if this were not enough, there is yet another twist to the confusion surrounding 2C-T-2 in the Netherlands. A synthetic amphetamine known as 4-MTA (para-methylthioamphetamine) was sold under the brand name S5 for a while in the Dutch smartshops. Structurally related to the toxic amphetamine PMA (para-methoxyamphetamine), 4-MTA was linked to several deaths and was removed from the market. The laboratory which analyzed the 2C-T-2 pills for Conscious Dreams also analyzed three batches of S5 tablets. While the first two batches were in fact 4-MTA, the third batch was found to contain 2C-T-2.

2C-T-2 was always seen as being a replacement for 2C-B, and it never reached 2C-B's level of popularity in the Netherlands. Never the less, it did however become extremely popular. A representative of De Sjamaan claims that "the most normal people of whom you would never expect, that they would even enter a smartshop, became very regular customers without disrupting their 9 to 5 live in any way." A representative of Conscious Dreams, when asked, gave a rough guess that perhaps 200,000 tablets of 2C-T-2 were sold total. An article on the Dutch party scene in the March 20, 1999 issue of Vrij Nederlan claimed that 2C-T-2 had become the most popular drug sold by the smartshops at that time, with several thousand pills being sold per week. Many people would take 2C-T-2 in combination with alcohol, or sometimes ecstasy, and go out for the night. In the nearly two years that 2C-T-2 was available legally in the Netherlands, not one bad incident involving it was ever reported.

2C-T-2's popularity spread beyond the Netherlands, as well. By July 2, 1998, Smart Drugstore in Sweden was selling 2C-T-2, and continued to do so until April 1, 1999, when it was banned by the Swedish government. It also apparently caught on in Germany, which made 2C-T-2 illegal by emergency scheduling on October 7, 1998, and has since rescheduled it two more times - a situation which will be discussed in the legal status section of this paper.

In January, 1999, a package containing 2C-T-2 was being returned to Conscious Dreams from Japan, and Dutch customs opened it. After reading the product information flier, an Adjunct Inspector decided that it was making pharmaceutical claims, due to terms like "psychedelic" and "hallucinations." Due to the fact that the government could not demonstrate 2C-T-2 was a hazard to public health, it was not made a scheduled drug under normal Dutch drug law. As a round-about method of banning it, it was instead declared to be an unregistered medicine on April 12, 1999.

Conscious Dreams stopped selling 2C-T-2 on April 6, 1999, after running out of stock. A period of confusion followed the banning of the drug in the Netherlands. The wholesaler stopped selling it and avoided giving a clear reason for why. Rumors began to circulate that the chemist who was manufacturing had either disappeared or been busted for manufacturing MDMA. When inquiring about availability from various smartshops, explanations ranging from "The wholesaler is having supply problems but we expect more soon" to "It has been made illegal" to "We don't know what's going on" were given to customers. Shops which still had supplies of the pills continued to sell them. Finally, on July 29, 1999, Conscious Dreams received papers from the Inspectie voor de Volksgezondheid (People's Health Inspector) in Haarlem informing them of the fact that 2C-T-2 had been banned. On July 30, Conscious Dreams sent out the following e-mail announcement:

To all of you interested in 2CT2

Since April 12 1999, the Dutch authorities have classified 2CT2
as an unregistered pharmaceutical. This means that manufacture,
sale, import, trade and possession of this substance will be
prosecuted. Since April 6 1999, Conscious Dreams has not
possessed any 2CT2, nor will she in the future.

We are sorry and hope you understand.

Conscious Dreams

Some smartshops kept selling 2C-T-2 until November 1999, when their supplies ran out. No arrests were made, however. Since then, 2C-T-2 has not become a black market drug in the Netherlands. This is probably due to the fact that it is somewhat more difficult for underground labs to manufacture than other drugs for which there are much more demand.

Blue Mystic

Starting in summer of 1999, 2C-T-7 made its appearance in the Netherlands. At the end of 1999, the manufacturer offered to sell the pills to Conscious Dreams, who had the material analyzed. Although the pills were found to be authentic, they decided to pass on it out of concern over legal repercussions. However, De Sjamaan and other smartshops began selling 2C-T-7 in early 2000, under the brand name Blue Mystic. The information flier lists the active ingredient under an alternative name, "PT-DM-PEA" (short for 4-propylthio-2,5-dimethoxy-phenethylamine) rather than 2C-T-7, this being done to avoid customers becoming confused between 2C-T-7 and 2C-T-2. Blue Mystic was originally offered in sets of three 7.5mg blue tablets, but this was later changed to being sold in packages of five tablets for 25 guilders. Several months later, the tablets were reformulated to 10mg, sold in packages of three. As with 2C-T-2 before it, prices vary between shops, for example Tambu Passionstore's price being $25.00 (US) for 5 tablets.

10mg Blue Mystics

7.5mg Blue Mystic

The product information states that women need 2-3 pills and men need 4-5 for an effective dose, although 15% of people need much lower doses. These figures are based on surveys which De Sjamaan conducted at the Entheobotany 2000 conference in Palenque, Mexico, as well as an on-going survey of their customers. The complete results of these surveys have not yet been made public because the project has not yet been completed. The most obvious problem with the Blue Mystic flier, however, is that it states booster doses do not work - they certainly do. When questioned about this, Ananda of De Sjamaan stated "Boosting does work. But not below the threshold, i.e. one can take 5 + 5 + 5 + 5 mg's, with 1.5 hours in between. Getting only a plus one, while a dose of 15 mg's on the same person would probably give a plus 2 or even 3. When this person experiences his or her plus 2, boosting would be a option. This became apparent when Blue Mystic was sold per 3 tabs of 7.5 mg's. Most women found it to be strong, while most men claimed it did not work."

At least two versions of the product information flier have been used. The first was distributed with the original 7.5mg tablets, and the second with the newer 10mg tablets.

Also, unlike 2C-T-2, Blue Mystic is being distributed to smartshops with instructions to store owners not to sell 2C-T-7 to everyone, to try and screen out customers who seem to be unstable or unprepared. Store owners are also being asked to talk to customers one on one and give them usage and safety information, so as to try and minimize any irresponsible behavior which might attract the attention of the authorities.

In July of 2000, VLOS issued a statement to member shops advising against selling 2C-T-7. This was merely a recommendation, however, and member shops were told they would not be expelled from VLOS if they continued to sell it. VLOS believes that the Dutch government will not accept the sale of synthetic drugs by smartshops, both because of a perceived, but not actual, connection with ecstasy manufacturers and because of concern about international pressure.

Getting Attention

Meanwhile, elsewhere in the world, both of these drugs became available from a handful of chemical supply companies. 2C-T-7 in early January, 2000, followed by 2C-T-2 in April, became available as pure powders. Unlike the Dutch smartshops, these companies were not offering their products for human consumption, and in fact explicitly forbade such use in their customer agreements. Also unlike the Dutch smartshops, these companies do business internationally. As a result of this new global availability, interest in these drugs grows among serious researchers and recreational users alike.

Between February 21 and 27, 2000, at the Entheobotany conference in Palenque, Mexico, 2C-T-7 (mostly in the form of Blue Mystic tablets, but also as pure chemical) was being assayed by a large group of people. One attendee, Casey Hardison, seized this opportunity to do some research. He designed an informal survey which he passed out to people who had taken 2C-T-7. Hardison collected fourty-eight completed surveys which he analyzed, and his findings were published in the Summer 2000 issue of the Bulletin of the Multidisciplinary Association for Psychedelic Studies.

By late summer, 2000, 2C-T-7 has gained significant popularity with some groups of people. Discussion of this drug on the Internet has grown exponentially over the course of the year. It has earned several nicknames, including "lucky 7," "7-up," "7th heaven," "beautiful" and "tripstacy." In spite of its availability, interest in 2C-T-2 has not kept pace with 2C-T-7.

The Black Market

In late September 2000, reports began to surface from a small group of people in Canada that they had encountered a few 2C-T-7 pills circulating at a rave in Vancouver, BC. These pills were being sold under the name "Red Raspberry" and were rumored by some to contain a mixture of 2C-T-7 and "speed." One person, who had used 2C-T-7 previously, tried the pills and thought it was unlikely they contained any amphetamines, and commented that the pills were not particularly strong either. Based on his experience, he estimates the pills contained perhaps 10 or 12 milligrams of 2C-T-7. No analysis of the pills have been done to confirm whether or not they contain any 2C-T-7.

Red Raspberry
#7

Reports of other pressed pills of 2C-T-7 have appeared sporadically. On September 3, 2000, a person going by the name ghost-2501 posted to the Internet discussion board Bluelight that he had heard of pills called "Green Fish" which were alleged to be 2C-T-7. The pills had a logo which was described as "a tilted square with an eye and a triangle making the tail." In July 2000, the harm reduction group DanceSafe posted a pill to their laboratory pill analysis web site which was called a "Number 7," sent in by someone in the Chicago area. Although the lab did not detect any known drugs, there are some curious factors, and it must be kept in mind that since 2C-T-7 is a relatively obscure chemical, the laboratory doing the analysis likely did not have a reference standard for detecting it, so it can not be ruled out that the pill could have contained it. The most obvious pieces of evidence are the name of the pill and the #7 stamp appearing on it. Adding to the mystery is the fact that the pill reacted to a Marquis reagent assay with a "slight orange color." Pure 2C-T-7 gives a salmon orange reaction to Marquis reagent. I contacted DanceSafe's national director Emanuel Sferios about this to see if the pill was still available for further analysis, and he told me that he would find out. I received no further response, so it seems likely the pill was disposed of, leaving this an unsolvable mystery.

2C-T-7 has also circulated on the drug market in its natural form, a powder. Trey Mosmeyer of the Austin Dance Alliance, a Texas based harm reduction group, reports that 2C-T-7 experienced a brief period of popularity in the Dallas area during the last half of 2000. A few dealers caught wind of the substance and began marketing it as a new legal drug which "makes acid look like nothing." It was sold under the names "beautiful" and "belladonna," the last being particularly dangerous as it could easily lead an uninformed person into thinking that it is the same drug found in the plant belladonna. A few problems arose due to confusion with the drug ketamine. People who were unaware of the existence of 2C-T-7 saw the drug, and due to its similar appearance, mistook it for ketamine and snorted ketamine-size doses of the drug, leading to some rather severe panic reactions. This was compounded when people who mistook the drug for ketamine turned around and sold it to others as ketamine. In a few cases this may not have been accidental. Mosmeyer said he heard of two cases where people intentionally misrepresented 2C-T-7 as ketamine, adding that "they were both soulless bastards who didn't care, but needed to sell it as something people knew."

On various Internet based discussion forums, occasional reports have surfaced of people selling 2C-T-7 on the drug market. In most cases, it is being sold either under its proper name or a slang term such as "lucky 7" or "beautiful." A few isolated reports have been made of it being misrepresented as other substances, such as mescaline. Although it is impossible to tell the extent to which 2C-T-7 has been sold on the black market, it seems likely that it is a fairly uncommon occurrence. The general unfamiliarity of the drug-using public with the substances combined with the easy access to more established drugs likely has prevented them from becoming popular black market drugs.

Incidents

There have been a few tragic incidents reported involving 2C-T-7. While there have been quite a few reports of people who took too much and had severe panic reactions, there have been only seven serious incidents reported. Considering that the drug has probably been taken thousands of times by hundreds of individuals, and considering the reckless usage patterns of some users, this seems a testament to the relative safety of the drug. Thus far, no serious incidents have been reported involving 2C-T-2, and considering the longer history that drug has, this seems to indicate that it to may be a quite safe drug. Nevertheless, no drug is entirely safe and abnormal reactions, allergies, and overdoses all could lead to an unexpected tragedy. In addition, it must be remembered that no formal studies into toxicology have ever been done for these drugs, so the risks are largely unknown or theoretical at best.

One of the first reported tragedies occurred at the end of August 2000 in Europe, and was posted to the Lycaeum on September 1, 2000. Three people got together and tried 2C-T-7. One took it orally, while the other two each insufflated 25mg, an unusually large dose when taken by this route. Three hours later one of the people who had snorted it began behaving strangely. He became somewhat delirious, unable to understand anything when spoken to, and repeating the same few sentences over and over again. Starting at 5 hours after snorting it, he began repeating action sequences. According to a witness, "first he would ask if he can wash is face, no matter what he got as an answer, he'd go splash water on his face, then sit down and ask for a cigarette, get up and ask if he can wash his face... and so on ...This lasted for hours." Eventually this stopped, but he kept speaking of strange things. According to the witness, "he told us about places underground where he lived and was a horrible centipede." Even at the eight hour point he is complaining about animals living in the walls and floor that wanted to eat him. The next morning, at the 16 hour point, he was still tripping. The other two people went to work, and when they came home later they found their friend in the bath tub with both wrists slit, and deep cuts up and down his harms. They called an ambulance, and the man was saved. When asked about it later, the man said he could not remember anything about what had happened. The most probable explanation here is that the person has an underlying mental condition which was triggered by taking an enormous dose of a powerful psychedelic drug.

The most tragic incident involving 2C-T-7 was the death of a 20 year old man named Jake Duroy in Norman, Oklahoma. I was first made aware of this death when a friend of Mr. Duroy responded to the 2C-T-7 user survey I was running in conjunction with Erowid. After interviewing several of Mr. Duroy's friends and reading articles in local newspapers (none of which ever mentioned the drug by name), I have been able to piece together what may have happened.

Jake Duroy had taken 2C-T-7 one occasion before, in July 2000, when he insufflated 15mg. He had no unusual reactions to it that time. Mr. Duroy was 20 years old, approximately 170 pounds, having no known medical conditions other than asthma [Erowid Note: we have received more recent information stating that Jake did not, in fact, have asthma] and was in good health, being a member of the Fellowship of Christian Athletes active in many sports. Jake was not taking any medications at the time of his death, and the only other drug he had used recently was some marijuana the night before his death.

Mr. Duroy and his friends had obtained some 2C-T-7 from a chemical supply company. After his death, a sample of the material was analyzed by the police lab and found to be pure, ruling out the possibility of a contaminated batch. The material was weighed out on a very accurate digital scale one of the friends had purchased, so the dose taken is fairly certain (though one friend said the he was not sure if Mr. Duroy had actually used the scale to weigh his dose, so this is still open to question).

On October 15, 2000, Jake Duroy and a group of friends got together at a house on the 1200 block of Dakota to take some 2C-T-7. Along with one other person, Mr. Duroy snorted a massive 35mg of the drug. Three other people present took lower doses orally.

Within twenty minutes of taking the 2C-T-7, Mr. Duroy became agitated and frightened, and complained of being cold. He began talking about "evil spirits" being in the room, and decided to retreat to a corner of the room to lie down and try to get warm with a blanket. He remained within sight of his friends, who were somewhat concerned about his agitated state. Other than some vomiting, which is a fairly common side effect, he seemed physically fine at this point. The other person who had snorted 35mg experienced similar symptoms, though milder. This person took a Rohypnol tablet and within an hour was asleep, having no further complications and little memory of the experience. At around ninety minutes after taking the drug, Mr. Duroy began to have convulsions, and began simultaneously vomiting and bleeding heavily from the nose.

When his friends realized Mr. Duroy was in trouble, they called a friend to come help them. They put him in the car to drive to the hospital. On the way to the hospital, they had to stop at a railroad crossing to wait for a passing train. They noticed Mr. Duroy had stopped breathing several times and tried to clear his airway. Had they instead called for an ambulance, perhaps this tragedy could have had a happier ending, as the hospital is only a five minute drive from the house where it happened. One can only speculate why they did not, but it seems likely it was out of fear. Some of the people present had been arrested on drug charges a few months earlier, and were afraid of what might happen if police came to the house. In this regard we can say that the War on Drugs played a very big role in the death of Jake Duroy and that in a country with more enlightened drug laws, Jake Duroy might not have died. On the other hand, when a life is at stake, such concerns need to take a back seat, and it is my opinion that not calling 911 in a situation like this can only be described as criminally negligent.

According to Norman police detective Don Blake, Mr. Duroy was brought into the emergency room at the Norman Regional Hospital at 2:20PM in full cardiac arrest, having died in the car on the way to the hospital. Police began investigating the incident, telling the local newspaper The Norman Transcript that they suspected the death was due to "some kind of designer drug." In the end, an autopsy determined that the cause of death was cardiac arrest brought on by choking on vomit.

One other serious incident was reported by a survey respondent. In this case, a young man in Mexico took 30mg of 2C-T-7 orally while out with some friends. While crossing a street, his friends noticed that he had stopped and was staring blankly at a street light. He then fell to the ground, hit his head, and began having convulsions. His friends called an ambulance. After being treated in the hospital, he was told he had suffered a mild heart attack. He did not tell the doctors he had taken 2C-T-7, because he was worried he would get in trouble for drug use. Instead, he told them he had fallen and hit his head because he was drunk. He had in fact drank some alcohol earlier, and had smoked large quantities of cannabis. He is described by his friend as being in relatively good health, though not very active. He had an abnormal heartbeat when younger, but was told by doctors that he had outgrown it. He was not on any medications at the time, but does use a range of drugs recreationally, including LSD, psilocybin, MDMA and ketamine. He had not taken any of these that day. He was released from the hospital with nothing worse than a mild concussion.

A very similar incident happened in Helsinki, Finland in August, 2000, and was also reported by a survey respondent. A woman known by the respondent insufflated 10mg of 2C-T-7, along with 10 other people who took the same dose. My informant said "the amount was not carefully measured and... I believe that the dose was a bit higher than 10mg because everyone was vomiting and I couldn't get a contact to them." Later the woman fell and hit her head on asphalt and had convulsions, and was taken to the hospital. My informant knew no further details, so it is unknown if the woman had taken any other drugs or had any medical conditions. Although all of the people who took it had a very strong response to the dose they took, my informant said that most enjoyed the experience. Several of them even took more 10 hours after the initial dose, when the effects had worn off.

Another survey respondent reported an overdose incident which happened in Sarasota, Florida. A friend of the respondent, which he described as "an idiot," obtained a 25mg sample of 2C-T-7. He injected the entire 25mg intravenously. According to witnesses he had a good experience for ten minutes, but then suddenly became very violent, throwing objects at people both real and imagined. It was pointed out that he is normally a very violent person. When his girlfriend tried to calm him down, he hit her several times. One witness called the police. After being unable to wrestle him down, they incapacitated him with a large amount of pepper spray. He was strapped to a stretcher and taken by ambulance to a hospital where he stopped breathing and slipped into a coma. He was put on a respirator and remained comatose for five days. Three days after regaining consciousness, he was released from the hospital. No charges were filed in this case.

Another overdose incident was posted to an anti-drug Internet message board called Cascade by a 15 year old boy named Mike, who lives in the United States. According to Mike, on Saturday, November 11, 2000, he snorted 25mg of 2C-T-7. In his own words, "I didn't know what was happening. Intense waves and overwhelming visuals were coming over me...feeling sounds, seeing feelings...not fun at all. I must have puked at least a liter. I told my parents that I thought I overdosed on a research chemical." He was taken to the emergency room, where he was put in the intensive care unit. As there is no mention of any life threatening symptoms, it is possible that Mike was admitted to the ICU as a precautionary measure by concerned doctors who had no idea what else to do. He says of the experience, "I only remember bits and pieces of what happened. If you have seen the movie "Fire in the Sky", I felt like the guy that was abducted. Being in severe confusion and tubes coming out of you is not fun. And urinating though a tube is not the greatest thing...it's even worse when they pull the tube out. I was released from the ICU Sunday. It was extremely scary." Not only does this incident dramatically highlight the fact that children should not use powerful psychoactive drugs, but it shows the complete lack of knowledge most medical professionals have about obscure psychedelic drugs.

One final incident is known to me only by hearsay. Two men in the Netherlands took unspecified doses of 2C-T-7, either before or after eating a greasy Chinese food meal. Later, either one or both of the men began to have a panic reaction, and became entangled in a barbed wire fence of some kind. When police arrived and tried to help him (or them) get freed from the fence, he (or they) refused help and tried to fight off the police. After being removed from the barbed wire, he (or they) got taken to a hospital for observation. One of the men apparently went into a coma for a few days, but recovered. No other details are available, unfortunately, and this could be simply a rumor. It is unknown if any other drugs were involved, or what the mental and physical health of the men was.

Moving On

By the end of 2000, much of the initial interest in 2C-T-7 began to fade, as the hype surrounding the drug began to be replaced by experience. When the drug first began attracting attention in various circles, particularly among Internet users, there were many misconceptions about the drug. Many people who had no familiarity with phenethylamine drugs other than MDMA were under the impression that 2C-T-7 was some sort of "candyflip" drug which mimicked the effects of combining MDMA with some LSD. People began to look at it as a potential new party drug. As more people tried it and became familiar with the effects, however, attitudes began to change. Over the course of several months, awareness began to spread that it is indeed a powerful mescaline-like psychedelic drug which may not be suitable for a night out dancing. Stories of panic reactions by people who had taken too much began to discourage people from taking recklessly large doses, something which was unfortunately quite prevalent initially. Word of Jake Duroy's death reminded people that this is a relatively new drug and that the risks remain largely unknown. The initial naive hype has slowly begun to fade, and many of the people looking for "the next ecstasy" have moved on to other things, returning 2C-T-7 to the realm of more serious researchers and psychonauts, though of course many people searching for a new recreational drug continue to try it. 2C-T-2 has remained relatively obscure and unpopular, owing perhaps to its reputation as being merely an inferior version of 2C-T-7.

As of yet, there has been no attention paid to these chemicals by the media, at least in the United States. There have been a few brief mentions of 2C-T-2 in the European media, due to the fact that this drug was available commercially there. In spite of the death of Jake Duroy, there have been no mentions of 2C-T-7 in the press other than a passing mention in the November 6, 2000 issue of FEED Magazine.

Little attention has been paid to these drugs by the legal authorities of any countries either. A few European countries made them illegal after 2C-T-2 was sold in the Netherlands, as described previously, but neither drug has attracted enough attention to warrant significant governmental actions.

It is impossible to predict what the future of these drugs will be, though there is much speculation. The only thing that can be said with any certainty is that whatever the future holds for 2C-T-2 and 2C-T-7, it is bound to be interesting.

 


Stolaroff's & Well's Study




Some of the most detailed research into 2C-T-2 and 2C-T-7 has been carried out by Myron J. Stolaroff. In 1993, Stolaroff published a paper along with Charles W. Wells titled "Preliminary Results with New Psychoactive Agents 2C-T-2 and 2C-T-7" in the Yearbook for Ethnomedicine 1993. This paper describes the results of research designed to determine if these drugs showed sufficiently interesting properties to warrant further investigation into their therapeutic potential as well as to discover what side effects they may have. MDMA, a drug with known therapeutic potential, was used as a benchmark for comparing the results.

Subjects for the experience were chosen based on two principal criteria. First, they had to have stable personalities, and second, they had to have no prior experience with any of the three drugs being used in the experiment (all but five, however, had prior experience with other psychedelic drugs). The sixty-three subjects were divided up into three uneven groups: seven were given MDMA, eight were given 2C-T-7, and the remaining fourty were given 2C-T-2.

In all cases, the drugs were administered in a friendly and supportive setting at a comfortable home with natural surroundings. All experiments were overseen by experienced guides, usually two per experiment. Most of the subjects took the drugs in groups of two, though experiments were conducted with groups as large as five and as small as a single individual.

Subjects arrived the night before the experiment, where they spent the evening discussing the drug they were going to be given and choosing a dose, as well as going over their current mental and physical states. Dosages were determined by the subject and the guides after discussing the effect ranges as well and taking into consideration other factors such as previous experience with other drugs. Those who expressed doubts were urged to start lower and take a supplemental dose later, if needed. In the morning, they were given the drug on an empty stomach, and given the entire day to devote to the experience. Supplemental doses were offered at the two hour point for those who wanted them. No formal procedure was in place for the experiments, and subjects were free to talk, walk outside, retreat to private rooms, or whatever else they wished. In the evening, after the experience was over, food was served. In conclusion, the subjects were required to fill out a simple questionnaire within a few days of the experiment.

Participants ranged between 18 and 67 years old. The range for those who took MDMA was 32 to 63, 48 being the average age. For the 2C-T-7 group the range was 30 to 57 with an average age of 42. The 2C-T-2 group ranged from 18 to 67 years old, with an average of 40.

The MDMA group all received 120mg, and all took a 40mg supplement at the two hour mark. The 2C-T-7 group took doses ranging from 20 to 25mg, with an average of 23.1mg, and six of the eight took supplemental doses. The 2C-T-2 group took from 10 to 30mg, with 15.7mg being average, and only eleven of the fourty took supplements. Supplements were found to be effective even as late as five hours after the initial dose, providing an almost immediate increase in activity.

2C-T-2 was found to reach full intensity in about two hours, with a five hour plateau followed by a gradual, usually pleasant descent back to baseline. These researchers found that 2C-T-2 was more emotionally opening than MDMA, and allows wider exploration of feelings. It was also found to permit more freedom of thought, more like LSD than MDMA in this regard. It was also found to enable more surfacing of repressed material than MDMA. Due to the fact that 2C-T-2 has much less of the centering qualities found with MDMA, being more like traditional psychedelics in that regard, this release of subconscious material can at times lead to some uncomfortable experiences.

2C-T-7 was found to be similar to 2C-T-2 but longer acting, more intense, and perhaps more euphoric. Stolaroff and Wells concluded that their sample size for this drug was too small and that further research was needed to define this drug's effects. The small sample size must certainly be taken into account when considering the results of the experiment.

Visually, 2C-T-7 was found slightly more active than 2C-T-2. For both drugs, 12.5% of the subjects reported open eye visual activity. However, 85% of the 2C-T-2 group reported no such activity, versus 75% of the 2C-T-7 group reporting no open eye visuals. None of the MDMA group reported such effects. 62.5% of the 2C-T-7 group reported improved visual perception, with 12.5% reporting worsened perception. With 2C-T-2, 47.5% reported improved visual perception, and 5% reported it worsened. None of the MDMA group reported worsened visual perception, and 42.9% reported it improved. Fully half of the 2C-T-7 group reported closed-eye imagery, as did 47.5% of the 2C-T-2 group. Only 14.3% of the MDMA group reported closed-eye imagery.

On the measure of clarity of thought, 2C-T-7 was found to produce the best results, with 87.5% of the subjects reporting it improved. Unfortunately, it also produced the largest percentage of subjects reporting a loss of clarity, 12.5%. 2C-T-2 produced less dramatic results, with only 75% reporting improvement and 5% reporting a decrease. MDMA also had very good results, with 84.6% reporting improvement and no reports of decreased clarity.

2C-T-7 gave the worst results for effects on flow of insights. Only 50% of subjects reported improvement, and 12.5% reported it worsened. 2C-T-2 produced much better results, with only 2.5% reporting the flow of insights worsened, and 77.5% reporting improvement. MDMA came in second, with 71.5% reporting improvement, and no reports of worsening.

2C-T-7 came in last on the ability to increase perception of high order meaning, with only 62.5% reporting an improvement. 2C-T-2 fared much better, with 82.5% reporting improvement. MDMA performed best in this regard, with 85.8% reporting improvement. None of the three drugs produced any worsening on this measure.

On the measure of feeling tone, 75% of the 2C-T-7 group reported an improvement. In the 2C-T-2 group, 80% reported an improvement, but 10% noticed a worsening in feeling tone. The entire MDMA group reported improved feeling tone.

2C-T-2 produced the worst results in the facilitation of communication. Of this group, 17.5% reported the ability to communicate with others worsened, but 62.5% reported it improved. 2C-T-7 produced better results, with 75% reporting improved communications, and no reports of worsening. MDMA produced the highest percentage reporting improvement, 85.7%, but 14.3% of this group did report a worsened ability to communicate.

An increase in energy level was reported by 37.5% of the 2C-T-7 group, and a decrease reported by 9%. 2C-T-2 did good on this measure, with 70% reporting an increased energy level, and 12.5% reporting a decrease. MDMA did very bad, with 42.9% reporting a decrease, and no increases reported.

2C-T-7 had the best results on overall functioning, with 69.2% reporting improvement and 9.2% reporting deterioration. 2C-T-2 came in second with 57.2% reporting improvement and 14.4% reporting deterioration. MDMA produced the worst results, with 56.5% reporting improved functioning and 15.9% reporting deterioration.

2C-T-7 produced the greatest percentage of experiences without physical side effects, 82.5%. 2C-T-2 had the worst results, with only 72% reporting the absence of physical side effects, however the intensity of side effects for 2C-T-2 was the lowest. Of the MDMA group, 79.3% reported no physical symptoms, although MDMA did result in the largest percentage of side effects described as distracting, 18.9% (versus 9.6% for 2C-T-7 and 8.3% for 2C-T-2).

Both 2C-T-2 and 2C-T-7 produced more complaints about nausea and vomiting than MDMA. 2C-T-2 was worst in this regard, with 10% of subjects reporting noticeable nausea, 17.5% reporting short lived distracting nausea and 5% reporting long lived distracting nausea. Vomiting was reported by 17.5% of this group. Of the 2C-T-7 group, 12.5% reported noticeable nausea and 25% reported long lived distracting nausea. Vomiting occurred in 25% of the group. MDMA produced the least nausea, with 28.6% of subjects reporting distracting but short lived nausea, and no instances of vomiting. Stolaroff and Wells speculate that the nausea produced by 2C-T-2 and 2C-T-7 may be due to the surfacing of psychological material, as they noticed that many of the subjects reporting nausea said they were aware of what was making them feel ill, and that the nausea disappeared when the issue was confronted.

2C-T-7 produced the highest incidence of muscle tension, with 37.5% of the group experiencing it to some degree. Muscle spasms and tremors were reported by 12.5% of the subjects. 2C-T-2 did a little better, with 32.5% reporting muscle tension. MDMA produced the most muscle tension, being reported by 42.9% of the subjects. It also produced the worst muscle tension, with 28.6% reporting it as long lasting and distracting.

2C-T-7 had the least effect on heart rate, though the exact results are unclear, as the paper states that 100% of the 2C-T-7 group experienced no change in heart rate, but then states that 12.5% reported noticeable change. Of the 2C-T-2 group, 67.5% reported no change in heart rate. Only 57.1% of the MDMA group reported no change on heart rate, and MDMA also produced the worst effects, with 28.6% reporting the effect on heart rate as distracting (versus 5% for 2C-T-2). Effects on blood pressure, strangely enough, run in the opposite order. Only 62.5% of the 2C-T-7 group reported no effect on blood pressure, compared to 67.5% for 2C-T-2 and 71.4% for MDMA.

Other unspecified physical side effects were reported by 20% of the 2C-T-2 group, 7.5% of the group reporting these effects as being distracting.

Asked if they would repeat the experience, 2C-T-7 got the largest number of "no" responses, 12.5%. Of those who would repeat it, 14.4% were happy with the dose they took, while 57.1% would take more. From the 2C-T-2 group, only 85% said they would repeat it, and 7.5% would not. Most, 52.9%, would take more, 8.8% would take less, and 26.5% would take the same dose. All the MDMA subjects said they would take MDMA again, 42.9% at a larger dose, 14.3% at a smaller dose, and 28.6% at the same dose.

In conclusion, the researchers determined that there were no noticeable contraindications for 2C-T-2 and 2C-T-7 in well motivated subjects. Writing in his book Thanatos to Eros, published a year later, Stolaroff describes 2C-T-2 as being an "excellent general purpose work horse," and a "comfortable, enjoyable vehicle" that can be used to explore a wide range of inner feelings and levels of thought. Because it has some MDMA-like euphoric centering qualities, 2C-T-2 is less likely than the classic psychedelics (such as LSD) to mire the user in disturbing aspects of the subconscious, and leaves the user with more volition. He states the effective dose range as 12 to 30mg, extending it 5mg beyond Shulgin's recommendation in PIHKAL. Stolaroff mentions that 2C-T-2 has occasionally been used in doses of 8 to 10mg by therapists monitoring patients who have taken MDMA. He goes on to describe 2C-T-7 as being an "excellent substance, very clear, very permissive," although it is clear he has less experience with it than with 2C-T-2.

Based on these findings, it seems that 2C-T-2 and 2C-T-7 are quite different in effects from MDMA, which would indicate different therapeutic applications. It would be interesting to do similar experiments comparing them to other drugs such as 2C-B and LSD, with which they seem to have more in common than MDMA. It would also be very productive to do a more equal comparative study between 2C-T-2 and 2C-T-7.

 


Casey Hardison's Survey




As mentioned previously, Casey Hardison, a graduate student at the University of Idaho, conducted an informal survey of 2C-T-7 users at the Entheobotany conference in Palenque, Mexico in February 2000. Noticing that quite a few people were conducting bioassays of the material, Hardison seized the opportunity to perform some informal impromptu research. He designed a survey which was handed out to conference attendees, and received 48 responses. The results of this survey were published in the Summer 2000 issue of the MAPS Bulletin under the title "An Amateur Qualitative Study of 48 2C-T-7 Subjective Bioassays."

Respondents were of various cultural and ethnic backgrounds, ranging from 24 to 73 years old. 29 respondents were male, 13 female, and the remaining 4 did not specify their sex. 33 of the respondents indicated no prior experience with 2C-T-7 prior to the conference, and 12 indicated they had previously used it from between 1 and 15 times.

The respondents used dosages in the range of 25 to 45mg, which worked out to 0.3 to 0.6mg/kg. The average time until effects were felt was 1.5 hours, with the range of variation being 15 minutes to 4 hours. Time until peak effects ranged from 1 to 6 hours, with the average being 3 hours. Duration of peak effects ranged from 1 to 5 hours, with 3 hours being average. Entire duration ranged from 8 to 18 hours with a median of 12 hours (not all respondents answered this question on the survey). Other drugs which were taken in conjunction with the 2C-T-7 were marijuana, dihydrocodeine, Valium, alcohol, and cocaine.

As far as side effects, nausea and upset stomach were the most commonly reported, with 7 respondents reporting general nausea or stomach discomfort and 3 reporting extreme nausea. Headaches were reported by 4 individuals, and muscle tension by 3. Abdominal cramps, tachycardia and renal pain each received one mention.

35 of the respondents indicated a willingness to repeat the experience, versus 7 who would not take 2C-T-7 again. 4 individuals did not respond to this question.

 



2C-T-2 & 2C-T-7 User Surveys




Originally, I had intended to simply analyze available first-hand experience reports to get a general picture of the effects of 2C-T-2 and 2C-T-7 for this paper. After some thought and discussing the difficulties involved with Earth of Erowid, I wrote up Internet based survey forms which Erowid agreed to host on their web site. Two surveys were made, one for each drug. They asked the same 27 question forms, and each survey was crosslinked to the other so that people who had tried both drugs could easily find and answer both surveys. Questions were designed to study several aspects of these drugs. First was to form a demographic picture of users - for example age, sex, weight, medical condition. Second was to study the logistics of use - dose, route of administration, and frequency. Users were asked several questions each about side effects and aftereffects, and were given a chance to make general comments about the drugs.

The survey software and results (with submitters' email and IP addresses removed) will be made available through Erowid in the future for further analysis. The surveys were put online September 17, 2000 and ran until December 1, 2000. Announcements were made on various Internet drug forums and mailing lists.

Due to the anonymous nature of submissions, this survey should not be considered to be scientific. Surveys were all reviewed in an effort to remove invalid submissions. All responses considered invalid were archived and taken out of the analysis. Some surveys were modified slightly to be easier for the software to read, but all original versions were archived. Some people sent in two surveys, one intended to replace the other. These people's first submissions were archived as well, as were accidental duplicate submissions.

After the removal of unusable submissions, there were 423 valid responses to the 2C-T-7 survey and 43 valid responses to the 2C-T-2 survey. It is unfortunate that there were not more responses to the 2C-T-2 survey, as the ten-fold difference in sample sizes makes comparisons between the two drugs somewhat less conclusive than what was hoped for.

Demographics

The age range of 2C-T-2 users was 16 to 47 years old, with the average age being 27. One respondent did not list their age. The age range for 2C-T-7 users was 14 to 64 years old, with the average being 24. Four of the 2C-T-7 users did not list their age.

The weight range for 2C-T-2 users was 110 to 270 pounds (50 to 122 kilograms), with the average being 164 pounds (74 kilograms). One respondent did not give their weight. For the 2C-T-7 users, the weight range was 85 to 330 pounds (39 to 150 kilograms) with the average being 166 pounds (75 kilograms). Four of the 2C-T-7 respondents did not give their weight.

For both drugs, the overwhelming majority of the respondents were male. In the case of 2C-T-2, 39 respondents (90.70%) were male and 4 (9.30%) were female. Of the 2C-T-7 users, 378 (89.36%) were male, 42 (9.93%) were female, and 3 (0.71%) did not give their sex.

Medical Conditions

Respondents were asked to list any pre-existing conditions they may have, including any medications they take. A wide range of medical conditions was listed. Respondents also took a variety of medications which will be discussed later in the section on drug combinations.

Among the 2C-T-2 users, people reported ADD/ADHD, affective disorder, allergies of various kinds (severe enough to require medication, in some cases), anxiety disorder, asthma, bipolar disorder, and hypertension. One respondent indicated that he was addicted to GHB.

The 2C-T-7 users reported quite a few more conditions, owing to the much larger sample size. These included ADD/ADHD, affective disorder, allergies, anxiety disorder, arteriosclerosis, asthma, autozymal tremors, back pain, bipolar disorder, clinical depression, Crohn's disease, insulin dependent diabetes, and endometriosis. One reported having a heart murmur which doctors had ruled "of no medical concern." Moving down the list, other reported conditions included high cholesterol, hypertension, migraines, osteoporosis, rheumatic arthritis, a history of seizures, and stomach ulcers.

Routes of Ingestion

In so far as routes of ingestion, 39 (90.70%) of the 2C-T-2 users reported having tried the drug orally, with 36 (83.72%) indicating this as their usual route. 10 respondents (23.26%) had tried taking it via insufflation, and 7 (16.28%) indicated this was their usual way of taking the drug.

The 2C-T-7 users appeared to be more adventurous by comparison. 343 of them (81.09%) said they had tried the drug orally, with 288 (68.09%) indicating this as their usual way of taking it. 200 (47.28%) had tried it via insufflation, with 118 (27.90%) indicating it as their usual route. 38 respondents (8.98%) had tried smoking the drug, with 12 (2.84%) saying it was their usual way of using the drug. 7 users (1.65%) had tried it rectally, with 5 (1.18%) indicating that this was their usual route. 7 respondents (1.65%) stated that they had tried the drug in either an intramuscular or subcutaneous injection, and 3 users (0.70%) tried intravenous injection, but none of the users indicated injection was their usual way of taking it. One user who tried it indicated that injection was a bad idea because the material is not very soluble.

Dosages

The typical doses used by those taking 2C-T-2 orally ranged from 5mg to 40mg, with the average being 20.76mg. For those who snort the drug, the typical doses ranged from 2.5mg to 35mg, with the average being 13.07mg.

For 2C-T-7, the typical oral doses ranged from 1mg to 125mg, with the average being 26.64mg. Twelve of those who said their usual way of taking 2C-T-7 was orally did not give a typical dose. It should be noted that the user who listed 125mg as their typical dose was a one time user who took this amount accidentally due to a weighing error. For those who indicated insufflation as their usual route, typical doses ranged from 0.5mg to 50mg, with the average being 14.98mg. Eight of the insufflating users did not indicate their typical dosages. Of those who said they usually take the drug rectally, typical dosages ranged from 7mg to 33mg, with the average being 15mg. Typical doses used by those who smoke the drug ranged from 1mg to 40mg, with 12mg being the average. One of the respondents who usually smokes the drug did not give a typical dose.

Overall, users of 2C-T-2 were fairly certain that their dose measurements were accurate. 21 respondents (48.84%) said they were very certain of their dose and 18 (41.86%) said they were pretty certain. By contrast, 3 respondents (6.98%) indicated they were not very certain of their dose, and only 1 (2.33%) responded "Who knows?" to this question. When considering routes of administration, the oral users were more certain of their doses than those who snort the drug. 19 (52.78%) of the oral users were very certain of their dose, 16 (44.44%) were pretty certain, and one (2.78%) responded "Who knows?" In contrast 2 of the insufflating users (28.57%) were very certain of their dose, another 2 (28.57%) were pretty certain, and 3 (42.86%) were not very certain.

Turning to the 2C-T-7 users, there was somewhat less sureness about dosage measurement. Overall, 149 respondents (35.22%) were very certain of their dose, 180 (42.55%) were pretty certain, 62 (14.66%) were not very certain, 31 (7.33%) responded "Who knows?" and 1 person (0.24%) did not respond to the question. As with 2C-T-2, when the route of administration is taken into consideration, the picture changes sharply. Of those who usually take 2C-T-7 orally, 124 (43.06%) were very certain of their dose, 115 (39.93%) were pretty certain, 30 (10.42%) were not very certain, and 19 (6.60%) were very unsure. Of those who usually snort the drug, 21 (17.80%) were very certain of their dose, 57 (48.31%) were pretty certain, 30 (25.42%) were not very certain, and 10 (8.47%) were not certain at all. Of the rectal users, 1 (20%) was very certain of dosage accuracy, 2 (40%) were pretty certain, and another 2 (40%) were not very certain. Finally, out of those who normally smoke their 2C-T-7, 3 (25.00%) were very certain of their dose, 6 (50%) were pretty certain, 2 (16.67%) responded "Who knows?" and 1 (8.33%) did not answer this question.

Usage Patterns

The 2C-T-2 users indicated that they had used the drug between 1 and 20 times, with the average being 3.69 times. Users were asked to give the month and year of the first time they had taken it and the last time they had taken it. Elapsed time between the two dates ranged from none in the case of one-time users to two and a half years, with the average being around five months.

The 2C-T-7 users responded that they had taken the drug between 1 and 200 times, with the average being 4.78 times. One respondent did not respond to this question. Elapsed time between first and last uses ranged from none to four years, with the average being around two and a half months. Five respondents did not indicate the timespan of their use.

In the case of the user who had taken 2C-T-7 200 times, it should be pointed out that he was not using it as a psychedelic but rather as a nootropic. The respondent was a 43 year old male who said that he had "ingested almost 2 grams of 2CT7 over a 7 month period," taking "a daily +1 museum dosage of 5-10mg." No tolerance was noticed. He said "I found it to be one of the most powerful cognition enhancers I've ever encountered," but mentioned that "it was difficult to stop taking 2CT7 and I used a SSRI to regain seratonin balance." Discussing the long term effects this has had on him, he says "the introspective and emotionally beneficial aspects of 2CT7 have allowed me to develop and appreciate my relationships with people. 2CT7 has also helped to remove personal obstacles that have prohibited progress in my life."

When asked about frequency of use, 1 (2.33%) of the 2C-T-2 users indicated weekly use, 9 (20.93%) indicated they used it two to three times per month, 2 (4.65%) indicated they took it monthly, 5 (11.63%) said they took it every two months, 5 (11.63%) that they took it twice per year, and 13 (30.23%) that they took it yearly or less. 5 respondents (11.63%) did not respond to the question.

Turning to the 2C-T-7 users, 16 (3.78%) indicated that they had used it more than once a week. 33 (7.80%) indicated that they used it weekly. 77 (18.20%) said they used it two to three times per month. 84 (19.86%) indicated monthly use. 32 (7.57%) said they used it every two months. 27 (6.38%) replied that they used it twice per year. 102 (24.11%) said they used it yearly or less. 36 (8.51%) did not answer this question.

Willingness to Repeat

Most of the 2C-T-2 users indicated a desire to repeat the experience. Overall, 24 (55.81%) of them said they would repeat it at the same dose. 11 (25.58%) said they would like to take a higher dose. 1 (2.33%) indicated a desire to repeat the experience, but at a lower dose. Only 3 (6.98%) did not want to repeat the experience, and 4 (9.30%) were undecided. When taking routes of consumption into consideration, the picture changes. Of those who used it orally, 22 (61.11%) said they would repeat it at the same dose. 7 (19.44%) expressed a desire to take more, 1 (2.78%) said they would take less. 3 (8.33%) did not want to repeat the experience, and another 3 (8.33%) were unsure. Out of those who snort it, 2 (28.57%) would repeat it at the same dose, 4 (57.14%) wanted to try a larger dose, and 1 (14.29%) was unsure about repeating the experience. When asked why they would choose not to take 2C-T-2 again, 6 people referred to the side effects, and one person said he simply found it not up to his expectations, preferring other of the sulfur-containing phenethylamines.

Overall, the 2C-T-7 seemed slightly more eager to repeat the experience. 203 (47.99%) said they would repeat it at the same dose, 126 (29.79%) wanted to take more, and 22 (5.20%) would repeat it but at a lower dose. 21 (4.96%) said they did not want to take it again, and 40 (9.46%) were undecided. 11 respondents (2.60%) did not answer this question. Again, routes of administration were a big factor. Of the oral users, 129 (44.79%) said they would like to take it again at the same dose, 97 (33.68%) would like to take more, and 13 (4.51%) would like to try a smaller dose. 10 (3.47%) said they did not want to take it again, and 29 (10.07%) were unsure if they would repeat it. 10 (3.47%) of the oral users did not answer this question. Of those who snort the drug, 66 (55.93%) expressed an interest in taking it again at the same dose, 22 (18.64%) would like to try a higher dose, and 8 (6.78%) would repeat it at a lower dose. 11 (9.32%) were not interested in doing it again, 10 (8.47%) were uncertain, and 1 (0.84%) did not answer this question. 4 (80%) of the rectal users said they would take it again at the same dose, and 1 (20%) would take a higher dose. Of the smokers, 4 (3.33%) would repeat it at the same dose, 6 (50.00%) would like to try a higher dose, 1 (8.33%) would repeat at a lower dose, and 1 (8.33%) was undecided.

The 2C-T-7 users had a wider range of reasons for not wishing to use it again. Eleven people indicated that they found 2C-T-7 weak or uninteresting, or just preferred other drugs. Around 20 indicated that the side effects outweighed the positive effects for them. Eight people remarked that they had tried snorting it and that the pain of that experience was enough to put them off. Six people made comments about the comedown or aftereffects being unpleasant. Nine people said they found the trip too intense for their tastes. Five people said they wanted to see more research done, or had concerns about the drug's safety. Other reasons given included the length of the effects, price, or inconsistent effects.

Side Effects

Both drugs produced a range of physical side effects. Out of all the 2C-T-2 users, 8 (18.60%) reported the side effects were barely noticable. 11 (25.58%) found them to be mild and of short duration. 10 (23.26%) found them short but distracting, and 5 (11.63%) found them to be short but severe. 3 users (6.98%) found the side effects lasted a long time but were mild. 5 (11.63%) found them long and distracting. 1 person (2.33%) did not respond to this question. When looking only at users who take the drug orally, 4 (11.11%) found the side effects were barely noticable. 10 (27.78%) found that the side effects were short and mild, 9 (25.00%) found them to be short but distracting, 5 (13.89%) found them short and severe, 3 (8.33%) reported mild but long lasting side effects, and 4 (11.11%) found them long and distracting. 1 of the oral users (2.78%) did not respond. Of the insufflators, 4 (57.14%) found the side effects barely noticable. 1 person (14.29%) found them short and mild, 1 (14.29%) found them short and distracting, and 1 (14.29%) found them long and distracting. I suspect these figures may be highly unreliable, as the sample size of people who snort 2C-T-2 is only 7 individuals. Given a larger sample size I believe that the side effects would be more pronounced for insufflation than for oral use, as is the case with 2C-T-7.

Out of all the 2C-T-7 users, 62 (14.66%) found the side effects to be barely noticable. 121 (28.61%) found the side effects to be short and mild. 105 (24.82%) found them to be short and distracting. 34 (8.04%) found the side effects to be short but severe. 53 respondents (12.53%) found the side effects mild but long lasting. 29 (6.86%) found them to be long and distracting. 8 (2.60%) found the side effects to be long lasting and severe. 11 people (2.60%) did not indicate the level of side effects intensity. When comparing different routes of consumption, there are some rather big differences. Oral administration seems to have the mildest level of side effects, with 49 people (17.01%) reporting them as barely noticable. 87 respondents (30.21%) reported the side effects as short and mild. 66 (22.92%) said the side effects were distracting but short, and 18 (6.25%) said they were short but severe. 33 people (11.46%) said the side effects were long and mild, 20 (6.94%) said they were long and distracting, and 6 (2.08%) found them long and severe. 9 (3.13%) of the oral users did not rate the intensity of side effects. People who snort 2C-T-7 had a significantly worse time. 12 (10.17%) found them to be barely noticable. 28 (23.73%) found the side effects short but mild. 33 (27.97%) found them to be short and distracting, and 15 (12.71%) found them to be short and severe. 17 people (14.41%) found the side effects to be long but mild, 9 (7.63%) found them long and distracting, and 2 (1.69%) found them to be long and severe. 2 (1.69%) of the insufflators did not answer this question. Of the rectal users, 2 (40%) found the side effects to be short and mild, 2 (40%) found them short and distracting, and 1 (20%) found them long and mild. Of those who smoke 2C-T-7, 1 (8.33%) said the side effects were barely noticable. 4 (33.33%) found them short and mild, 4 (33.33%) said they were short and distracting, 1 (8.33%) said the side effects were short but severe, and 2 (16.67%) found them long but mild.

Nausea was the most common side effect of 2C-T-2, being reported by 26 (60.47%) of all users. Broken down by route, 23 (63.89%) of oral users and 3 (42.86%) of insufflating users reported nausea. Nausea was also the most common side effect for 2C-T-7, with 265 (62.65%) of all users reporting it. Broken down by route, 180 (62.50%) of oral users, 76 (64.41%) of insufflating users, 3 (60%) of rectal users and 6 (50%) of smokers experienced nausea.

Vomiting was reported by 10 (23.26%) of all 2C-T-2 users. By route, 8 (22.22%) of the oral and 2 (28.57%) of the insufflating users reported that they threw up. 2C-T-7 gave somewhat worse results, with 129 (30.50%) of all users vomiting. By route, oral users fared much better, with 77 (26.74%) throwing up, compared to 45 (38.14%) of insufflating users, 2 (40.00%) of rectal users, and 5 (41.67%) of the smokers.

For both drugs, muscle tension was the second most common side effect. Of all 2C-T-2 users, 14 (32.56%) experienced it. By route, 12 (33.33%) of oral users and 2 (28.57%) of insufflating users reported muscle tension. Again, 2C-T-7 gave noticably worse results, with 197 (46.57%) of all users reporting muscle tension. By route, 141 (48.96%) of oral users, 47 (39.83%) of insufflating users, 3 (60%) of rectal users, and 6 (50%) of smokers reported muscle tension. Many people pointed out that this muscle tension was focused in the neck and shoulders. A few people indicated it occurred primarily during the early part of the trip.

Out of all 2C-T-2 users, 8 (18.60%) reported diarrhea. Of the oral users, 7 (19.44%) reported diarrhea, as did 1 (14.29%) of the insufflating users. For 2C-T-7 users this seemed to be less common, with only 26 (6.15%) of all users reporting diarrhea. By route, 18 (6.25%) of oral users, 5 (4.24%) of insufflating users, and 3 (25%) of 2C-T-7 smokers reported diarrhea.

Tachycardia was reported by 7 (16.28%) of all 2C-T-2 users - all of whom had taken it orally, making the percentage of oral users reporting it 19.44%. For 2C-T-7, 92 (21.75%) of all users experienced tachycardia. Broken down by route, 60 (20.83%) of oral users, 29 (24.57%) of insufflating users, and 3 (25%) of smokers reported tachycardia.

Hypertension was reported by 1 2C-T-2 user, who took it orally, making the percentage of all users experiencing this effect 2.33%, or 2.78% of oral users. Again, 2C-T-7 did somewhat worse, with 25 (5.91%) of all 2C-T-7 users reporting hypertension. By route, 16 (5.55%) of oral users, 8 (6.78%) of insufflating users, and 1 (8.33%) of smokers reporting it.

Dehydration was reported by 7 (16.28%) of 2C-T-2 users. Of those taking it orally, 6 (16.67%) reported dehydration, as did 1 (14.29%) of the insufflating users. 2C-T-7 gave similar results, with 76 (17.96%) of respondents reporting dehydration. By route, 53 (18.40%) of oral users, 20 (16.95%) of insufflating users, and 3 (25%) of smokers reported dehydration.

Headaches were fairly uncommon for 2C-T-2 users, with 4 (9.30%) users reporting them. These users all took it orally, making the occurrence of headaches with oral use 11.11%. Here, 2C-T-7 gave dramatically worse results. 135 (31.91%) of 2C-T-7 users reported headaches. By route, 92 (31.94%) of oral users, 36 (30.51%) of insufflating users, 2 (40%) of rectal users, and 5 (41.67%) of smokers got headaches. Several people commented that the headache seemed to come most often near the end of the experience, and some felt they may be due to dehydration. One person described the headache as "brain-freezesque" feeling. Another said that the headache was accompanied by a very intense buzzing pressure in the sides of his head.

Both drugs also caused various other side effects.

Of all 2C-T-2 users, 7 (16.28%) - all oral users, making up 19.44% of that group - reported other side effects. Side effects reported included a stomach ache, nasal congestion (in someone who took the drug orally), and a tingling pins-and-needles sensation in the extremities. One person reported feeling an unusual sensual arousal without any apparent external cause. One person reported confusion.

With 2C-T-7, 118 (27.90%) of all users reported other side effects. By route, 72 (25%) of oral users, 42 (35.59%) of insufflating users, 1 (20%) of rectal users and 3 (25%) of smokers reported miscellaneous side effects.

Most commonly reported were various body temperature related effects. People reported feeling cold, while others reported feeling hot. Some reported alternating sensations of hot and cold. One person said they could not tell if they were hot or cold. Several people reported an increase in sweating - one person described it as "extreme sweating." It seems possible that these temperature effects are perceived rather than actual, however. One person who felt feverish got out a thermometer and discovered that they had a normal 98.6° Farenheit temperature.

In addition to nausea, 2C-T-7 users reported other gastrointestinal side effects. Two people reported stomach cramps. A few reported symptoms of gas, including belching and flatulence. As noted earlier, one person felt the nausea induced by this drug is caused at least in part by gas. One person reported heartburn. One reported indigestion. Another reported consistently getting constipation for a day and a half every time he used it. One other person wrote that he experienced a "reduction in sphincter retention ability."

Four people reported tremors, combined with a loss of manual dexterity in one case. Another person reported muscle spasms in the extremities in the initial phase of the experience. One person reported an eye twitch. Trisma, or jaw clenching, was reported by several people. One reported joint pain. Some people experience confusion or delirium with large doses of 2C-T-7. Sensory overload was also mentioned with large doses. Some people reported periods of dizziness or loss of balance. One person reported hearing rubbing noises in the ears, another reported a temporary reduction in hearing ability. One person reported decreased salivation, another reported increased salivation. One individual who had taken it orally reported nasal congestion. One person reported persistent dry eyes. One reported a numbness in the right side of their body. Another mentioned a persistent feeling of the need to urinate. One person reported extreme sexual arousal and desire. Another reported trouble ejaculating, but speculated that could be due to some MDMA he had also taken. One person reported heart palpitations. One remarked on an amplified awareness of pains and itches. One person felt irritable. One person reported a pins-and-needles tingle in the extremities. One person who snorted what he called "an idiotic dose" of 20 to 26mg reported that he passed out.

When asked whether the level of side effects had changed with repeated use of the drugs, users of both drugs gave similar answers. 13 (30.23%) of 2C-T-2 users reported no change, 1 (2.33%) reported an increase, 4 (9.30%) reported a decrease, and 4 (9.30%) reported that the level of side effects varied from experience to experience. 21 users did not respond, either because they have not used 2C-T-2 more than once or because they simply chose not to answer. Of 2C-T-7 users, 136 (32.15%) reported no change in the level of side effects, 10 (2.36%) reported an increase, 51 (12.06%) reported a decrease, and 57 (13.48%) reported that the level of side effects is variable. 169 (39.95%) of the 2C-T-7 users did not answer this question.

People tried a variety of things in attempts to prevent or treat the side effects they experienced. Both 2C-T-2 and 2C-T-7 users tried many of the same things, so responses for both drugs will be summarized together.

Some approaches involved dietary changes. Fasting prior to taking the drugs was reported to help for the nausea. One person suggested not eating, but drinking plenty of water to prevent dry heaves. Other suggested a light snack helped prevent side effects. The survey included a question which asked respondents to indicate whether they had eaten before taking the drugs, but due to a technical glitch this question did not appear on the survey for a few days, and thus was not asked of all participants. Of the 2C-T-2 users, 30 were asked this question. Out of these 30, 11 (36.67%) took the drug on an empty stomach, and 19 (63.33%) took it after a light meal. Out of the 2C-T-7 users, 326 were asked this question. Of those, 152 (46.63%) took the drug on an empty stomach, 138 (42.33%) took it after a light meal, 29 (8.90%) took it after a heavy meal, and 7 (2.15%) did not respond to the question.

Of those who took 2C-T-2 on an empty stomach, 2 (18.18%) reported the side effects of the drug were barely noticable. 3 (27.27%) found the side effects short and mild. 4 (36.36%) found them short but distracting. 1 (9.09%) found them long and distracting. 1 (9.09%) did not specify the intensity of side effects. Out of the people who took 2C-T-2 after a light meal, 5 (26.32%) found the side effects to be barely noticable. 6 (31.58%) found them short and mild. 3 (15.79%) found them to be short but distracting. 1 (5.26%) found them short but severe. 2 (10.53%) found them long but mild, and 2 (10.53%) found them long and distracting. Due to the small sample size, these numbers are probably not very useful.

A clearer picture of the relation between an empty stomach and intensity of side effects can be seen with the 2C-T-7 responses, and it seems that the less food the user has in their stomach, the milder the side effects will be. Of those who took 2C-T-7 on an empty stomach, 23 (15.13%) reported the side effects were barely noticable. 49 (32.24%) reported they were short and mild. 36 (23.68%) reported short but distracting side effects, 11 (7.24%) reported short but severe side effects, 19 (12.50%) reported long but mild side effects, 8 (5.26%) reported long and distracting side effects, and 6 (3.95%) did not indicate the level of side effects they experienced. Those who took 2C-T-7 after a light meal fared a little worse, with 21 (15.22%) reporting the side effects as barely noticable, 35 (25.36%) reporting them as short and mild, 41 (29.71%) reporting short but distracting side effects, 11 (7.97%) reporting short but severe side effects, 19 (13.77%) reporting them as long but mild, 4 (2.90%) long and distracting, and 5 (3.62%) as long and severe. 2 (1.45%) did not indicate the intensity of side effects. The people who took 2C-T-7 after a heavy meal did significantly worse. Only 2 (6.90%) reported the side effects were barely noticable. 11 (37.93%) said the side effects were short but mild. Short but distracting side effects were reported by 3 (10.34%) of them, as were short and severe side effects and long mild side effects. Long and distracting side effects were reported by 6 (20.70%) of them. 1 (3.45%) did not indicate the level of side effects experienced.

Other approaches to reducing side effects involved various techniques such as deep breathing and other relaxation methods. Going for walks was recommended by one user for both nausea and muscle tension. Taking the drug in divided doses spaced out over an hour or so was recommended by some. One user wisely suggested simply taking low enough doses to get the consciousness altering effects but without the full blown side effects, sacrificing intensity for comfort.

Many users reported using other substances to treat side effects. Marijuana was used widely to treat nausea and muscle tension as well as to relax and enhance the experience. GHB, opiates, and benzodiazepines such as Valium and Xanax were also used to try and reduce muscle tension and anxiety - all with fairly good results, except for two users who reported that opiates increased their nausea. One person reported trying Gravol, an anti-nausea medication, with no success. One user tried Pepto Bismol and reported that it "works wonders." Another tried a mixture of baking soda and water, saying it helped calm the stomach for some time. One user who reported excessive nasal congestion said that vapor rub worked. Magnesium supplements were taken by one user to treat muscle tension. One person remarked that the nausea seemed to be caused in part by gas, and tried treating it with Tagamet - successfully.

Drug Combinations

People mixed a wide range of drugs with 2C-T-2 and 2C-T-7, for purposes ranging from medical need, to remedies or preventatives for the side effects of the drug, to enhancing or modifying the trip, to trying to sleep afterwards. Most people made no remarks about the effects the combination produced, if any. The few who did made only minor comments. In all, there were no dangerous reactions. Some who tried mixing different psychedelics reported the effects as overwhelming and frightening. Some found that alcohol and opiates increased their nausea.

2C-T-2 users tried combining the drug with a handful of other psychedelics, including 2C-T-7, 2C-B, 5-MeO-DMT, DMT, DOB, DPT, LSD, MDMA, mescaline, and psilocybin-containing mushrooms. Some tried mixing it with ketamine. Some reported using nitrous oxide during the trip. The piperazines BZP and TFMPP were combined with 2C-T-2. Cannabis was smoked during the trip. Sedative drugs tried with 2C-T-2 were alcohol, blue lotus (Nymphaea caerulea), clonazepam (Klonopin), GHB and GBL, and opium. Prescription drugs used by 2C-T-2 users were Claritin-D (containing pseudoephedrine and loratadine), dextroamphetamine (Dexedrine), pemoline (Cylert), sertraline (Zoloft) and venlafaxine (Effexor). One respondent indicated taking St. John's wort.

2C-T-7 users listed quite a few more drugs, owing to the larger sample size of the group. The list of psychedelics taken with it is fairly extensive: 2C-T-2, 2C-B, 4-acetoxy-DIPT, 5-MeO-DIPT, 5-MeO-DMT, AMT, DIPT, DMT, DPT, LSD, MDA, MDMA, mescaline, morning glory seeds, and psilocybin-containing mushrooms. Two people tried combining it with Amanita muscaria, and several reported smoking Salvia divinorum during the trip. Both ketamine and PCP were tried with 2C-T-7. Dextromethorphan was tried by quite a few people, with mixed results. Nitrous oxide was also a very popular combination, and reportedly a very successful one. The piperazines BZP and TFMPP were combined with 2C-T-7... interestingly, it was reported that BZP seemed to reduce the side effects of the 2C-T-7. A few people tried cocaine during the trip, and others tried a handful of other stimulants including methamphetamine, methcathinone, ephedrine, as well as prescription mixed amphetamine salts (Adderal). Caffeine was reported by two people to produce noticably strong stimulant effects including tachycardia. Cannabis was used successfully by many to treat nausea, to relax, and to enhance the trip. People tried several opiates as well, including codeine, heroin, hydrocodone, opium, and oxycodone. Results were mixed, with two of the oxycodone users reporting it worsened their nausea. GHB, GBL, and 1,4-butanediol all were tried, in many cases as a treatment for tension and anxiety - for which they seemed successful. Other sedative drugs tried were alcohol, alprazolam (Xanax), and diazepam (Valium). One person tried ether, and said it "totally ruined" his trip. Two sleep aids were tried, zaleplon (Sonata) and zolpidem (Ambien) - interestingly, both of these respondents indicated getting strong visual effects from the combinations. The person who took Ambien described the effect as "very very very amazing visuals in a slowly losing consciousness sort of way." Someone tried dimenhydrinate (Dramamine) for nausea, and as mentioned before cimetidine (Tagamet) was also employed for gaseous nausea. One person tried using the nootropic piracetam to potentiate 2C-T-7 with no luck. Turning to medicinal drugs, a variety of people took various psychiatric drugs: amitryptiline (Elavil), bupropion (Wellbutrin or Zyban), busiprone (Buspar), citalopram (Celexa), fluoxetine (Prozac), nefazodone (Serzone), nortryptiline (Pamelor), paroxetine (Paxil) and trazodone. One person took mirtazapine (Remeron) and noted that he seemed to have unusually strong reactions to 2C-T-7 compared to his friends. For arthritis, Ledetrexate and azathioprine (Imuran) were listed. Several people took birth control pills, but only one specified what kind (Alesse 21). Two kinds of antibiotic were listed, minocycline and penicillin. A range of allergy and asthma medications were used, including albuterol (Ventolin), beclomethasone dipropionate (Vancenase), budesonide (Pulmicort), fexofenadine (Allegra), fluticasone (Flovent), terbutaline (Bricanyl), and theophylline. For hypertension, bisoprolol (Ziac), doxazosin (Cardura), fosinopril sodium (Monopril), and hydrochlorothiazide. For high cholesterol, atorvastatin (Lipitor). A person who gets migraines took rizatriptan (Maxalt), while another took sumatriptan (Imitrex). Two kinds of anticonvulsant were taken by respondents, divalproex sodium (Depakote) and gabapentin (Neurontin). The person who used Neurontin remarked that when he took it, it would make the effects of 2C-T-7 slower to come on than usual. For stomach disorders, the medications ranitidine (Zantac) and Donnatal (a low dose mixture of belladonna alkaloids and phenobarbital) were taken. The other two medications listed were insulin and the acne treatment isotretinoin (Accutane).

Aftereffects

Turning to aftereffects, defined as effects occurring anywhere from the day after up to a week from use, both drugs seem to have produced similar results. Overall, 15 (34.88%) of 2C-T-2 users reported no aftereffects. 9 (20.93%) reported noticable but neutral aftereffects. 6 (13.95%) of 2C-T-2 users reported mildly positive aftereffects, and 3 (6.98%) reported very positive aftereffects. 7 (16.28%) reported mild hangovers, and only 1 (2.33%) reported a bad hangover. When looked at by route, 13 (36.11%) of oral users reported no aftereffects. 6 (16.67%) reported neutral aftereffects. 5 (13.89%) of the oral users reported mildly positive aftereffects, and 2 (8.33%) reported very positive aftereffects. 7 (19.44%) reported a mild hangover, and 1 (2.78%) reported a bad hangover. 1 (2.78%) of the oral users did not respond to this question. Turning to the users who snort 2C-T-2, 2 (28.57%) reported no aftereffects, 3 (42.86%) reported neutral aftereffects, 1 (14.29%) reported mildly positive aftereffects, and 1 (14.29%) did not answer the question.

In general, the aftereffects reported by 2C-T-2 users were similar to those from other psychedelic drugs. Six people reported feeling mentally or physically drained the next day. Three reported day-after headaches. One person reported having stomach pains for a few days, and one reported having mild gas and diarrhea when the drug was wearing off. One person reported lingering visual effects. Four people mentioned feelings of well being and mental clarity. One person reported feeling emotionally imbalanced, similar to that experienced after MDMA but shorter in duration. One person reported experiencing an "undefinable emotion lingering for some time afterward, deep and possibly sad but bound to joy, best word I can come up with is soulful - aware of connection to other feeling beings yet more in touch with individuality at same time, sometimes an OK lonliness leading myself to myself for companionship."

Of all the 2C-T-7 users, 149 (35.22%) reported no aftereffects. 86 (20.33%) reported neutral aftereffects. 64 (15.13%) reported mildly positive aftereffects, and 32 (5.75%) reported very positive aftereffects. 65 (15.37%) reported mild hangovers, and 16 (3.78%) reported bad hangovers. 11 (2.60%) did not respond to the question. Broken down by routes of consumption, 107 (37.15%) of oral users reported no aftereffects, 51 (17.71%) reported neutral aftereffects, 48 (16.67%) reported mildly positive aftereffects, 18 (6.25%) reported very positive aftereffects, 45 (15.63%) reported a mild hangover, 11 (3.82%) reported a bad hangover, and 8 (2.78%) did not respond. Of those who snort 2C-T-7, 35 (29.66%) reported no aftereffects, 32 (27.12%) reported neutral aftereffects, 15 (12.71) reported mildly positive aftereffects, 12 (10.17%) reported very positive aftereffects, 17 (14.41%) reported a mild hangover, 5 (4.24%) reported a bad hangover, and 2 (1.69%) did not answer. Of the rectal users, 1 (20.00%) reported no hangover, 1 (20.00%) reported mildly positive aftereffects, 1 (20.00%) reported very positive aftereffects, and 2 (40.00%) reported a mild hangover. Finally, of those who smoke 2C-T-7, 6 (50.00%) reported no aftereffects, 3 (25.00%) reported neutral aftereffects, 1 (8.33%) reported very positive aftereffects, 1 (8.33%) reported a mild hangover, and 1 (8.33%) did not answer the question.

Aftereffects reported by 2C-T-7 users were also very typical of the aftereffects produced by most psychedelics. Many users reported feelings of being mentally or physically exhausted. Some described these effects negatively, saying they felt drained or dazed. Just as many interpreted the effects positively however, saying they felt mellow and relaxed, even blissful. Some people reported that they felt energized after using 2C-T-7. Headaches, muscle aches, and stomach aches were reported frequently, but were generally mild. Many people compared the aftereffects of 2C-T-7 to the aftereffects of MDMA or LSD. In general, the aftereffects were mild, and even many of the people reporting exhaustion said that the aftereffects were milder than what they had experienced from other drugs.

Mentally, many people reported feeling very positive following a 2C-T-7 experience. Feelings of well-being and optimism lasting for days and a lifting of depression and anxiety were reported by quite a few respondents. On the other hand, some users reported feelings of depression, anxiety and paranoia following a 2C-T-7 trip. Many people reported feeling intellectually slowed the day after using 2C-T-7. Memory lapses, disorientation, mild confusion, and an inability to concentrate were reported to last for a day or two. Interestingly, a few people reported the opposite, with one person noticing that they felt their vocabulary increased, and that they were less likely to hesitate and say things such as "erm..." between words.

Lingering visual effects were reported by quite a few 2C-T-7 users. Increased perceptions of color and detail, minor distortions such as objects flickering or moving, and increased sensitivity to light were reported to last for up to several days by some people. In general, these effects were mild and in many cases considered a positive aftereffect.

One woman wrote that her mentrual cycle was thrown off after using 2C-T-7, but pointed out that she had used the drug at the Burning Man Festival, and that her period could also have been affected by both the harsh desert environment and other drugs she took at the festival. One other person wrote that two women he had taken 2C-T-7 had their periods thrown off as well.

When asked whether the level of aftereffects had changed with repeated use, 15 (34.88%) of 2C-T-2 users said it had not, 3 (6.98%) reported an increase, 2 (4.65%) reported a decrease, 3 (6.98%) reported that the level of aftereffects was variable, and 20 (46.51%) did not answer, either because they had not used 2C-T-2 more than once or did not choose to answer. With 2C-T-7, 166 (39.24%) reported no change in the level of aftereffects, 9 (2.13%) reported an increase, 23 (5.44%) reported a decrease, 50 (11.82%) reported aftereffects as being variable, and 175 (41.37%) did not respond.

A few users mentioned things they had tried to reduce aftereffects. These included drinking sugary fruit juices toward the end of the trip, taking aspirin the next day, and taking the serotonin precursor 5-HTP.

Quality Over Time

When asked if the experience had changed with repeated use, 15 (34.88%) of the 2C-T-2 users reported that quality of the experience remained the same. 4 (9.30%) thought the quality increased with repeated use. 6 (13.95%) said that quality varied from experience to experience. 18 (41.86%) did not respond to this question, either because they had not used 2C-T-2 multiple times, or simply because they didn't feel like answering the question. Of the 2C-T-7 users, 100 (23.64%) felt that there was no change in quality, 58 (13.71%) felt the quality had increased, 13 (3.07%) felt it had decreased, and 101 (23.88%) thought it varied from experience to experience. 151 (35.70%) of the 2C-T-7 users did not respond to this question.

Long Term Effects

Finally, when asked how they felt these drugs had affected them in the long term, defined as effects lasting at least a week after use, 15 (34.88%) of the 2C-T-2 users felt the drug had no long term effect on them, 8 (18.60%) felt that they had received psychological or spiritual benefit from using it, and 20 (46.51%) did not answer the question. Of the 2C-T-7 users, 127 (30.02%) felt there were no long term effects from their use, 125 (29.55%) felt they had benefitted from the drug, 9 (2.13%) felt they had been psychologically or spiritually harmed by it, and only 6 (1.42%) felt they had been harmed in a physical organic way. 156 (36.88%) of the 2C-T-7 users did not answer this question. It is possible that the high percentages of users who did not answer this question may reflect the fact that many users have only used the drug for a few times over a short period, and perhaps they felt it was too early to tell what the lasting effects are. Of course, this is purely conjecture.

 



Pharmacology




Effects

2C-T-2 and 2C-T-7 are phenethylamine psychedelics with effects similar to mescaline and 2C-B. The effects of the psychedelic drugs are notoriously difficult to describe. While most produce at least some objectively measurable effects, such as pupil dilation or increased heart rate, the primary effects of the drug are in the mind and are therefore extremely subjective. People who have experienced these drugs agree that the mental changes produced are so far out of the ordinary range of human consciousness that they are impossible to accurately describe. It might be comparable to trying to explain music to a person born deaf.

Psychedelic drugs do not all produce identical effects, but they do generally produce similar effects. Each drug produces different variations on a theme. Not surprisingly, describing the differences between them is nearly as difficult as explaining what these drugs do in the first place. To extend the previous analogy, trying to describe the differences between mescaline and 2C-T-2 to a person who has only used mescaline is something like trying to explain Bach to a person who has only ever heard Miles Davis. Trying to explain these same differences to a person who has never used a psychedelic drug would be as if trying to explain the differences between zydeco and techno to a deaf person.

I will not try to explain the subjective effects of either psychedelics in general or of 2C-T-2 and 2C-T-7 specifically in great detail. Instead, I have selected quotes from a wide range of first hand reports written by users and collected them as appendices to this paper. I feel that these quotes do a much better job of conveying some picture of the range of effects these drugs can produce than any attempt at reducing them to measurable symptoms could.

This being said, a few generalities can be stated.

2C-T-2 produces effects which develop over the course of one to two hours after oral ingestion, and which last for approximately six to eight hours. When insufflated, the effects develop much faster, over the course of five to thirty minutes, and the effects wear off much sooner, approximately three to four hours after ingestion.

2C-T-7 likewise develops over several hours when used orally, taking up to three hours in some cases to reach full effects. The duration of the experience is much longer than with 2C-T-2, lasting from eight to fifteen hours. Insufflated, the effects come on rapidly, as with 2C-T-2. The trip is also much shorter, lasting from four to eight hours.

Both drugs produce strong visual effects for most people. Qualitatively the visuals are often compared to those produced by mescaline or 2C-B. Among people who have tried both 2C-T-2 and 2C-T-7, there is some division as to which of the two produces more powerful visual effects. The visual effects of both are described as being very similar, but not exactly identical. One warning: in the case of 2C-T-7, there have been reports that with extremely high doses, the visual effects can become so strong that it becomes virtually impossible for users to make sense of their surroundings. While this has not been reported in any published 2C-T-2 reports, it seems likely it could happen with the proper dose. This should be taken into account when choosing a setting for taking the drug, and a sober observer is recommended for large dose experiences.

The closed eye imagery produced by these drugs is often described as being stunningly realistic, and often accompanied by a feeling of being physically in the scene. Some users have observed that the closed eye imagery from 2C-T-2 and 2C-T-7 tends to be more coherent than the imagery from drugs like LSD. Rather than the rapid-fire abstract or symbolic imagery of tryptamines, the images from these phenethylamines tend to form scenes which often have coherent themes or event sequences.

Mentally, many users describe their states of mind as being very lucid. Users with past experiences taking tryptamine psychedelics such as LSD or psilocybin point out this lucidity as being in sharp contrast to their experience with tryptamines. Many users report feeling an unusual emotional openness with themselves and with others, an effect which is often compared with MDMA. Many people describe being able to examine their emotions and their lives with a very objective and detached point of view, which they claim allows them to be honest with themselves and confront things they normally avoid thinking about. Many other typical psychedelic mental effects are reported, including negative ones. Anxiety, paranoia, and full blown panic attacks can occur. Pre-existing negative emotions can be amplified. Extreme feelings of time dilation are commonly reported with both drugs. In general, the mental effects are similar to those of mescaline or 2C-B.

In very high doses, both drugs can cause delirious states in which the user loses touch with reality and may not be aware of their actions. This seems particularly true of 2C-T-7, and there are numerous reports of delirious states, especially when the drug is snorted. There is at least one published report of a delirious state from a large oral dose of 2C-T-2, however.

Physically, 2C-T-2 and 2C-T-7 produce a range of effects. Some of these are pleasant or neutral, while others are uncomfortable and are therefore labelled as side effects. For a more detailed analysis of the frequency of side effects, refer to the analysis of my user survey results found earlier in this paper, as well as the summaries of the research done by Stolaroff, Wells, and Hardison.

Many people report positive physical sensations, including a warm glowing feeling starting in the chest and spreading out through the body. Reports of dramatically increased limberness are common, particularly with 2C-T-7. Enhancement of all five senses is reported very frequently.

The most commonly reported unpleasant effects of these drugs are nausea and occasionally vomiting. Around sixty percent of survey respondents for both drugs reported nausea, with slightly more 2C-T-7 users reporting nausea than 2C-T-2 users. About twenty-three percent of 2C-T-2 users reported vomiting, as did around thirty percent of 2C-T-7 users. Stolaroff and Wells got better results, with only around thirty-three percent of the 2C-T-2 subjects and thirty-eight percent of the 2C-T-7 subjects reporting nausea, and about eighteen percent of the 2C-T-2 subjects and twenty-five percent of the 2C-T-7 subjects vomiting. Their subjects, regardless of which drug was taken, often mentioned that they felt the nausea was caused by psychological factors. They reported knowing what was making them feel ill, and that the nausea went away once they confronted the issues. Most reports indicate that the nausea usually occurs in the early stages of the experience, that it passes quickly, and that it is generally mild and does not detract significantly from the value of the trip. It can be severe or long lasting in some cases however, particularly with large doses. In addition to nausea and vomiting, other minor digestive discomforts were reported, including diarrhea and gas.

Muscle tension was reported by about a third of 2C-T-2 users and nearly half of 2C-T-7 users, based on both my surveys and the experiments done by Stolaroff and Wells. Often, this tension is focused on the shoulders and neck muscles. In addition, Stolaroff and Wells point out that about thirteen percent of their 2C-T-7 subjects reported muscle spasms or tremors.

2C-T-7 produced headaches for nearly a third of users responding to my user surveys. In contrast, only around ten percent of 2C-T-2 users reported headaches. Many first hand reports from 2C-T-7 users also mention headaches, and users often point out that these headaches tend to occur during the tail end of the trip.

Increased heartbeat and raised blood pressure are common with both drugs, as with virtually all psychedelic drugs. Although much of this is probably due to psychological factors such as anxiety, it is very likely that 2C-T-2 and 2C-T-7 do have stimulant properties similar to mescaline.

It is crucial to remember that all drugs are capable of producing unexpected results in some percentage of the population. All people have different biochemistries, and there is always the possibility that someone may be allergic to a given drug, or may have some enzymatic peculiarity which causes abnormal metabolism of certain drugs. Anybody considering trying a new drug must take this into account and start with very low doses and work up gradually until they are sure they do not have any unusual response to the drug. As many have said regarding drugs, "your mileage may vary."

Aftereffects

Aftereffects of both 2C-T-2 and 2C-T-7 are typical of psychedelic drugs in general. Aftereffects from both drugs are generally mild, and often are described as positive.

Most commonly reported are feelings of being mentally and physically exhausted. This is not necessarily felt to be bad, and is often described as a lazy but pleasant afterglow rather than a hangover. People report feeling optimistic, euphoric and energized following trips with 2C-T-2 and 2C-T-7. In some cases, people report feeling mental sluggishness following use, including impaired memory recall (interestingly, there are several mentions of temporary aphasia, or difficulty in remembering some words when speaking to someone), mild confusion or disorientation, and an inability to concentrate. The mental aftereffects of both drugs are often compared to LSD and especially MDMA, although many users report that the negative aftereffects are much milder than from MDMA.

Headaches, muscle aches, and occasional stomach problems have been reported. In general, these are mild and are easily cured with relaxation and a good revitalizing meal. Other than tiredness, both 2C-T-2 and 2C-T-7 seem to produce little in the way of physical aftereffects.

Dosage and Routes

The appropriate dosages and routes of administration for 2C-T-2 and 2C-T-7 are a matter which is open to much discussion. In addition, accurate measurement of doses is an issue of major importance.

Alexander Shulgin recommends a dose of 12 to 25mg orally for 2C-T-2. The Internet drug archive Erowid lists 5mg as a threshold dose, 10 to 15mg as a light dose, 16 to 32mg as a typical dose, and 32 to 48mg as a strong dose - all for oral use. Respondents to my 2C-T-2 usage survey used oral doses ranging from 5 to 40mg, with the average being approximately 20mg. Some respondents had tried snorting 2C-T-2, with dosages ranging from 2.5 to 35mg, with the average being approximately 13mg.

Dosages for 2C-T-7 seem to be much more variable. Shulgin recommends a dosage of 10 to 30mg orally, adding that "the range is intentionally extended on the lower side to include 10 milligrams, as there have been numerous people who have found 10 or so milligrams to be quite adequate for their tastes." Erowid lists 3 to 5mg as threshold, 10 to 20mg as light, 15 to 30mg as typical, 20 to 50mg as strong, and 40 to 60mg as heavy doses for oral use. For insufflation, 1 to 3mg is given as a threshold dose, 2 to 8mg as a light dose, 5 to 10mg as a typical dose, 10 to 15mg as a strong dose, and 10 to 25mg as a heavy dose. Respondents to the 2C-T-7 survey indicated a much wider range in dosage. For oral use, dosages ranged from 1 to 125mg, with approximately 27mg being average. For insufflation, dosages ranged from 0.5mg to 50mg, with the average being approximately 15mg. Rectal users listed dosages from 7 to 33mg, with 15mg being average. Those who smoke 2C-T-7 listed dosages from 1 to 40mg, with 12mg being the average. There is little data on dosages used for injections, but three or four reports have appeared on the Internet by people who have tried this route have listed dosages in the range of 1 to 3mg for both intramuscular and intravenous injections.

Individual sensitivities seem to vary greatly with 2C-T-7, in sharp contrast to 2C-T-2. While some people get powerful effects from 10mg orally, others report needing to take 60 or even 90mg orally to get any worthwhile effects.

Regarding routes of administration, there is much debate. Based on both the survey results and on a review of various first hand reports, oral use seems to be the best way to use either drug. People taking them orally report far fewer, milder and shorter side effects than those who snort them. Qualitatively, oral users tend to report much more positive experiences, and those who snort the drugs tend to report far more unpleasant experiences characterized by both physical and mental distress. Advocates of insufflating it often say that they use the drug that way because they require unusually large doses when taken orally, so snorting the drug is done primarily out of economical concerns. The other reasons often given for preferring insufflation over oral use are that the drug hits much faster when snorted and that the trip is shorter (primarily a concern among 2C-T-7 users). Advocates of oral use argue that the trip produced by this route is much gentler on mind and body, more serene, more productive, physically more comfortable, and safer owing both to a much less steep dose-response curve and to a smoother transition into altered consciousness, allowing the user to gradually get accustomed to the new state and preventing panic. One other argument in favor of not insufflating either is that there is the possibility of damaging the nasal passages when snorting these drugs. I personally know a young man who used 2C-T-7 by insufflation a number of times who did enough damage to his nasal passages that he had to go to the hospital and have his nose cauterized after experiencing severe nose bleeds.

There are not enough reports from people using the drugs rectally, by injection or by smoking to draw any really meaningful conclusions. For rectal use and smoking, the level of side effects appears to be in between what oral use and insufflation produce. As for taking them by injection, the few people who have discussed trying this route have not written very positive reports. It seems significant that of the 10 survey respondents who reported trying injections, not one indicated that injection was their preferred route.

Measurement of doses is a topic of very serious concern with both 2C-T-2 and 2C-T-7. With the exception of the pressed pills sold in the Netherlands and several black market 2C-T-7 pills, both drugs are available only in the form of pure powder or crystals. Owing to the fact that both drugs are active in doses under 50mg, this presents difficulties in measuring accurate doses. Optimally, the user should have a scale accurate to 1mg. Unfortunately, scales this accurate can cost hundreds or even thousands of dollars - far beyond the range of most freelance researchers or recreational users. Because of this situation, various methods have been devised for measuring doses without a scale.

One of the most popular and most accurate is volumetric measurement. In this technique, a known quantity of drug is dissolved in a known volume of liquid; for example, a gram of 2C-T-2 could be dissolved in 200ml of alcohol. Doses may then be measured out by volume using an eyedropper with milliliter measurements, a graduated cylinder, or even milliliter measuring spoons. Using the previous example, 1ml of 2C-T-7 solution would contain 5mg of drug. For this method, an alcohol based solution (using vodka or grain alcohol) offers some advantages. First, the alcohol will prevent bacterial contamination. Second, alcohol evaporates easily, so it becomes possible to measure a dose volumetrically and then let it evaporate off to leave an accurately measured dose of powder. Third, anecdotal reports indicate that 2C-T-2 and 2C-T-7 may be somewhat more soluble in alcohol than in water. If water is used, tap water should be avoided as it contains numerous contaminants which could potentially react with the drugs - for example, chlorine can break down many chemicals. If this method is used, care must be taken to store the solution in an air tight container to prevent evaporation from altering the concentration and throwing off dosage calculations.

Some people have tried to measure doses out visually. This may be as primitive as repeatedly halving a pile into supposedly even parts, or it can be done by what is known as the graph-paper method. For the graph paper method, a sheet of graph paper is placed under a pane of clear glass. A known quantity of powder is then poured onto the glass, and formed into an even sided shape of even thickness. In theory, you will then have an equal ammount of powder covering each square on the paper. For example, if you had 100mg covering 10 squares, there will be 10mg over each square. You could then divide this up by aligning a razor with the lines on the paper and separating the drug into 10 piles each approximately containing 10mg. Unfortunately, visual measurements are not accurate enough to be safe for use with 2C-T-2 or 2C-T-7. Even using the graph-paper method, differences in particle density make it impossible to ensure the same ammount of powder is on each square. The act of separating off a portion of the pile with a razor will move the powder remaining in the main pile. Visual methods such as repeated halving or the graph paper technique may be sufficient for drugs with dosages measured in the hundreds of milligrams, but for something as potent as 2C-T-2 or 2C-T-7, they are simply unacceptable. A difference of 1 or 2mg can produce dramatically different results, especially for routes of administration other than oral use. There are numerous reports on the Internet from individuals who have tried visual dose measuring that have learned this the hard way after accidentally taking far larger doses than intended.

Receptor Affinities

Unfortunately, no research has been done to determine the receptor affinities of either 2C-T-2 or 2C-T-7. We are forced to examine related drugs and to extrapolate from that data to try and form a hypothesis as to the receptor affinity of these drugs. This is of course made harder by the fact that the mechanisms by which even well studied drugs like mescaline work are still not fully understood.

Mescaline is known to interact with only one subclass of serotonin receptors, known as the 5-HT2 receptors. This is in contrast to tryptamine psychedelics which can interact (both agonistically and antagonistically) with a number of serotonin receptor types. The highest concentration of 5-HT2 receptors is in the cerebral cortex, an area of the brain for which mescaline has been found to have a high affinity.

It is suspected that mescaline's sympathomimetic activity is due to different processes than its psychedelic properties. Some have suggested that mescaline is competitive for adrenergic receptors. There is some evidence that mescaline stimulates or competes for alpha-adrenergic receptors. No evidence has been found for beta-adrenergic receptor interaction. There is some evidence that mescaline may act via catecholamine rather than cholinergic mechanisms. Other studies suggest that mescaline blocks the release of acetylcholine.

Studies done on rat aortas have found that 2C-B is a partial agonist for both 5-HT2 and alpha-1-adrenergic receptors. In concentrations of 10(-6) M it acts as a competitive 5-HT2 antagonist, but acts as a non-competitive antagonist in concentrations of 2.8 x 10(-5) M.

ALEPH-2, the amphetamine homologue of 2C-T-2, has been studied in rats and mice. Based on the animals' performance in a memory and anxiety model known as the elevated T-maze, researchers believe that ALEPH-2 has "anxiolytic, amnestic as well as sedative and/or motor depressant actions." When tested for receptor affinity, it was found that ALEPH-2's affinity "for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABA A receptors, the affinity was micromolar or lower."

Based on this evidence, it seems likely that the psychedelic activity of 2C-T-2 and 2C-T-7 are due to 5-HT2 receptor interactions, as with mescaline, 2C-B and ALEPH-2. The sympathomimetic properties of these drugs are likely due to agonistic activity at alpha-1-adrenergic receptor sites. Considering the numerous reports of delirium and other anticholinergic-like effects from high doses of 2C-T-7, it seems at least possible that these drugs do have some kind of effect on the acetylcholine system. The receptor affinities of 2C-T-2 and 2C-T-7 are definitely worthy targets for further study, especially the differences between the two.

Metabolism

No studies have ever been performed on the metabolism of 2C-T-2 or 2C-T-7. The metabolism of the related drugs 2C-B and mescaline have been studied however, and based on this it is possible to construct hypothetical metabolic pathways for 2C-T-2 and 2C-T-7.

Studies of human volunteers given mescaline have found at least 11 metabolites excreted in urine, as well as mescaline itself, which makes up 60% of the excreted material. Another 30% of the original drug is excreted as 3,4,5-trimethoxyphenylacetic acid. Another 5% is excreted as the metabolite N-acetyl-beta-(3,4-dimethoxy-5-hydroxy)-phenethylamine. Several other trace metabolites, including N-acetylmescaline and 3,4-dimethoxy-5-hydroxyphenethylamine, are also excreted.

Studies with animals and in vitro studies have found that mescaline undergoes oxidative deamination. There is some question as to what enzyme does this however, with some researchers suspecting monoamine oxidase, some suspecting diamine oxidase, and some suspecting both may be involved. Enzymatic N-acetylation, as well as O-demthylation of the methoxy groups have also been demonstrated, but these are minor metabolic routes in humans.

The metabolism of 2C-B (2,5-dimethoxy-4-bromophenethylamine) has been studied both by in vitro studies with rat livers and by analyzing urine samples from humans who had used the drug. In addition to some unchanged 2C-B, metabolites included 2,5-dimethoxy-4-bromophenylacetic acid, 2,5-dimethoxy-4-bromobenzoic acid, and 2-methoxy-5-hydroxy-4-bromophenethylamine. By comparing this data to what is known about mescaline metabolism, it seems likely that 2C-B follows a similar metabolic pathway.

Extrapolating from this, it seems likely that much 2C-T-2 and 2C-T-7 may be excreted unchanged, with oxidative deamination being the main metabolic pathway for the remainder. This would produce 2,5-dimethoxy-4-ethylthiophenylacetic acid in the case of 2C-T-2, and 2,5-dimethoxy-4-propylthiophenylacetic acid in the case of 2C-T-7. Some of the drugs are also likely metabolized by other pathways such as O-demethylation or N-acetylation. One direction for future research which may prove interesting is to compare the metabolism of 2C-T-2 and 2C-T-7. There seems to be much wider range of responses to 2C-T-7 than for 2C-T-2, as was discussed under dosage considerations. This may be indicative of some difference in the metabolism of the two drugs.

Tolerance

There are mixed reports regarding the tolerance forming properties of 2C-T-2 and 2C-T-7. While some people have noticed a definite tolerance, a couple users have reported being able to use 2C-T-7 for several days in a row without any noticeable decrease in effects. One user reported taking low doses of 2C-T-7 daily for several months as a cognitive enhancer, saying that there was no noticeable tolerance. Studies done with mescaline show that tolerance develops after two to three days of daily use, and that it disappears within three to four days of the last dose. Likewise, tolerance to 2C-B has been reported if the drug is used frequently.

Cross-tolerance with other drugs has not been explored deeply. One respondent to the 2C-T-7 usage survey remarked that a 25mg dose of 2C-T-7 taken on the night of a day in which psilocybin had been taken. The respondent felt there was a strong cross-tolerance effect at work. Another survey respondent noted that a 27mg dose of 2C-T-7 taken thirty-six hours after a 20mg dose of 2C-T-2 produced no effect, indicating that there is a cross tolerance between the two.

Beyond this, we can try to extrapolate from related drugs. Mescaline has been found to produce cross-tolerance with tryptamines such as psilocybin and LSD. Mescaline also appears to be cross-tolerant with the inactive chemical 2,5-dimethoxyphenethylamine and the stimulant N,N-dimethylmescaline. It seems likely that cross-tolerance exists between closely related phenethylamines such as 2C-T-2, 2C-T-7, 2C-B and mescaline as well.

Contraindications

Sadly, the limited knowledge about how 2C-T-2 and 2C-T-7 work makes it impossible to say for certain what the risk factors for these drugs are. We can apply a few standard contraindications for this class of drug, and it is possible to make some educated guesses about potential risks based on published experience reports and by extrapolation from related drugs. The possibility of yet unknown risk factors can not be ruled out however, and anyone considering experimenting with these drugs must keep in mind that they are sailing in largely uncharted waters.

One contraindication can be given with absolute certainty: Women who are (or suspect they may be) pregnant and nursing women should avoid all drugs not prescribed by a doctor. This applies especially to 2C-T-2 and 2C-T-7, which are after all still experimental psychedelics. There are absolutely no justifiable reasons for taking such a drug when you are physiologically supporting another life. Although there have been no studies on what the risks of taking these drugs while pregnant, there have been some studies done with the related drug mescaline on human tissues in vitro. Mescaline has been found to inhibit cellular mitosis by inhibiting spindle apparatus formation in a manner similar to colchicine and colcemid, which could conceivably slow the growth of a developing embryo or fetus. It should be pointed out that studies done on the Huichol tribes of Mexico have found no significant chromosomal abnormalities among the peyote users versus the non-users, indicating that mescaline does not share the mutagenic properties of colchicine and colcemid. Mescaline has also been found to constrict blood vessels in the human placenta in a manner similar to serotonin. In lower doses, mescaline has been found to enhance serotonin-induced uterine contractions, and causes uterine contractions on its own in higher doses. Although pregnant women and children among the Huichol have routinely used peyote with no demonstrable negative health effects, it is wise to err on the side of caution and avoid all drugs during pregnancy unless there is a medical need. Also, while mescaline may be closely related to 2C-T-2 and 2C-T-7, they are different drugs and what applies to one does not necessarily apply to the others.

Various standard psychedelic contraindications also certainly apply. People who have a personal or family history of psychotic disorders such as schizophrenia or bipolar disorder should not use psychedelic drugs unless doing so in a therapeutic setting under the supervision of a trained psychologist or psychiatrist. These drugs can weaken reality boundaries, and could easily lead to a psychotic break or worsen an already existing psychotic state. Similarly, people with personality disorders such as multiple personalities should also avoid taking these drugs except in therapeutic settings, as psychedelics can dramatically damage ego boundaries. Individuals with various emotional disorders as well as people going through temporary emotional crises should exersise caution with psychedelic drugs. While these drugs can provide valuable insights and emotional healing, they can also drastically worsen negative emotions. It may be wise for such people to make use of a guide for the experience, whether that be a psychologist, a spiritual advisor, or simply a trusted friend who can help direct the experience into a process of release and healing. For people who have little or no prior experience with psychedelics, the presence of a guide should be considered mandatory. Even individuals who are experienced with psychedelics may wish to make use of a guide for their first time out with 2C-T-2 or 2C-T-7 if their prior experiences have all been with tryptamine class drugs such as LSD or psilocybin rather than with phenethylamine class drugs, as the two families of drugs can produce very different results.

Beyond pregnancy, nursing and psychological factors, we must venture into the realm of the hypothetical. These contraindications and warnings are based on review of first hand reports from 2C-T-2 or 2C-T-7 users and on extrapolation from research on mescaline. While this may be overcautious in some cases, it must be remembered that no formal scientific studies have ever been done on 2C-T-2 or 2C-T-7, so extreme caution is wise.

People who have a personal or family history of seizures or convulsions should avoid 2C-T-2 and especially 2C-T-7. Quite a few first hand experience reports mention various effects such as muscular twitches and tremors, and a small percentage of users responding to my 2C-T-7 survey mentioned such symptoms. Several of the people reporting tremors stated that they seemed to originate in the legs and move upward. Several studies have found that mescaline can produce mild tremors in normal dosages. In higher dosages, these can become quite strong. A 1957 study by Pierre Deniker using 10mg/kg doses of intravenous mescaline hydrochloride found that such doses can produce rather severe tremors, but that the tremors seem to be partially under voluntary control and cease spontaneously several hours later. Chlorpromazine was found to eliminate these tremors. Studies on dogs and monkeys have found that mescaline can produce tremors as well as clonic and tonic convulsions in high doses. Although apparently harmless in healthy people, it is possible that these effects might trigger a more serious incident in people who have a convulsive disorder such as epilepsy. Again, it also can not be taken for granted that the convulsive actions of 2C-T-7 are caused by the same mechanisms as the actions of mescaline - this is purely based on extrapolation. Interestingly, mention of tremors or convulsions are conspicuously absent from the reports by 2C-T-2 users. It is unknown whether this is because nobody is experiencing these effects or simply because they are not mentioning them.

There have been three reported incidents involving convulsive symptoms from 2C-T-7 which are serious enough to cause concern, all of which were described in detail in the historical section of this paper. Of greatest concern is the death of Jake Duroy. Around ninety minutes after snorting a massive 35mg dose of 2C-T-7, Mr. Duroy began to have convulsions while simultaneously vomiting and bleeding from the nose. He soon went into cardiac arrest and died on the way to the hospital. An autopsy ruled the cause of death to be choking due to aspiration of vomit. While convulsions are a normal symptom of choking, there is also the possibility that the death was caused by an overdose of the drug itself. In studies on rats, fatal doses (LD50 = 370mg/kg intraperitoneally) of mescaline cause flexor convulsions after a period of hyperactivity, followed by respiratory arrest and cardiac arrest a few minutes later. If Mr. Duroy's death was in fact due to an overdose rather than simply choking, then this would seem to indicate that either 2C-T-7 has a dramatically lower LD50 than mescaline or that Mr. Duroy had an extreme sensitivity to the drug. The significance of the two other incidents mentioned is more problematic, as both involved head injuries. In one of the cases, the convulsions were accompanied by an apparent mild heart attack. This patient had a childhood history of abnormal heartbeat.

This leads us to the next contraindication. 2C-T-2 and 2C-T-7, like any other psychedelic drugs, should not be taken by individuals with cardiovascular problems. Tachycardia was reported by 16.28% of 2C-T-2 users and by 21.75% of 2C-T-7 users responding to my surveys. One person with premature ventricular contractions had an unusual episode which may have some connection using 2C-T-7. It is likely that this situation is connected to use of beta-blocker drugs, so it is summarized further on in the section on drug interactions. Hypertension was reported by 2.33% of 2C-T-2 users and 5.91% of 2C-T-7 users, although these numbers are probably insignificant since its unlikely many people had access to blood pressure monitors during their trips. Headaches were reported by 9.3% of 2C-T-2 users and by 31.91% of 2C-T-7 users, and it is possible that this is indicative of raised blood pressure, although dehydration and other factors could also account for the headaches. Turning once again to a related drug, mescaline has been found to increase blood pressure. Mescaline may increase heart rate, but can also decrease heart rate in higher doses. Mescaline can cause heart palpitations, and one 2C-T-7 survey respondent did mention having heart palpitations as well. Mescaline has also been found to be a vasoconstrictor in higher doses.

One final caution is based entirely on extrapolation from mescaline. Mescaline has been shown to affect blood sugar levels. One study involved large intravenous doses (10mg/ml), and resulted in an average increase in blood sugar of 35.1%, reaching a maximum at around one hour after injection and returning to normal in two to four hours. Interestingly, a study performed on rats using much higher doses (30 to 100mg/kg) found that mescaline sharply lowered blood sugar levels. The rat study also found evidence that insulin lowered the LD50 of mescaline. While these doses involve unusually high doses of a different drug, diabetics may wish to pay extra attention to their blood sugar levels when using 2C-T-2 or 2C-T-7. There was one 2C-T-7 survey respondent who mentioned having insulin dependent diabetes, and he reported no problems.

Drug Interactions

Drug interactions are always a complex issue, as the actions of each drug combine with each other and with the biochemical idiosyncrasies of the user. The results can be unpredictable, and with every drug added to the mix, the unpredictability of the results increases. In the cases of 2C-T-2 and 2C-T-7, this is complicated even further by the fact that their pharmacologies are still largely theoretical. Based on reports from users and extrapolation from closely related drugs, a few observations can be made as to how 2C-T-2 and 2C-T-7 may interact with other drugs.

A broad range of drugs have been combined with these two phenethylamines. In many cases, particularly with non-psychoactive medical drugs, the users have not reported any unusual reactions. There are many reports of combinations with other psychedelic drugs, where the results have been synergistic as one would expect. Combinations with other psychoactive drugs have been largely predictable; for example, combining 2C-T-2 or 2C-T-7 with benzodiazepines or GHB produced anxiolytic and sedating effects. To summarize all the nuances of these interactions could easily be a paper on its own, and so I will summarize here only those interactions which are unusual or dangerous.

The beta-blocker drugs metoprolol and atenolol were both involved in an unusual reaction reported by an individual taking them for premature ventricular contractions. This person first took a dose of metoprolol to deal with some PVCs he had been having. Later, after the drug had reduced the PVCs to a negligible level, he snorted 6mg of 2C-T-7. Within 10 minutes the 2C-T-7 reached peak effects, and simultaneously he began experiencing more PVCs than he had ever had in his life. Concerned, he took a sublingual dose of metoprolol, which produced no apparent reduction in the PVCs. The next day, he was still having an unusually high level of PVCs, so he began taking atenolol. This proved no more effective than the metoprolol had been. The PVCs got progressively worse over the course of a week, reaching a point where every other heartbeat was a PVC. He became lightheaded and short of breath, almost passing out at times. This obviously greatly distressed him. He even consulted his doctor, who had him wear a halter monitor to record his EKG readings for a day. After a week since the episode began, he realized that the more atenolol he took, the worse the PVCs became. He stopped taking the atenolol and felt "80% better" within two days. Within three weeks the PVCs were almost entirely gone, and did not recur for at least two months. The significance of this and whether or not the 2C-T-7 played any role are open to speculation. Another beta-blocker, bisoprolol, was used by a 2C-T-7 survey respondent with no unusual reactions reported.

One person reported that the anticonvulsant drug gabapentin (Neurontin) seemed to delay the onset of 2C-T-7's effects.

Stimulants of various kinds seem to be potentiated by 2C-T-2 and 2C-T-7. Caffeine has been reported to produce noticeably strong stimulant effects when combined with 2C-T-7. Several people have reported using cocaine with 2C-T-7, with some saying that the combination produces strong stimulation, and others mentioning a powerful euphoria. Combinations of 2C-T-2 or 2C-T-7 with amphetamines have been reported, with some people indicating the mix was not recommended but without going into details as to the actual effects. Benzylpiperazine, interestingly, has been reported to reduce the physical side effects of both 2C-T-2 and 2C-T-7 by several individuals. One person, however, reported that combining 150mg of benzylpiperazine with 1.5mg 2C-T-7 (route was not specified, but presumably was insufflated) produced a frightening tachycardia, with a pulse of over 160.

Reports of combinations with dextromethorphan are mixed. Some users have reported extreme delusional states from this combination. Combinations of 2C-T-2 and 2C-T-7 with ketamine, which has some pharmacological similarities to dextromethorphan, seems to have the opposite result. People who have tried combining ketamine with 2C-T-2 or 2C-T-7, as well as the related 2C-B, report that they find it easier to remember and integrate the experience than when the ketamine taken alone.

Opiates of various kinds have been combined with both 2C-T-2 and 2C-T-7. While in most cases the results were neutral or positive, there are at least two reports where combining oxycodone with 2C-T-7 produced significant nausea.

The prescription sleep aids zaleplon (Sonata) and zolpidem (Ambien) were each reported by single individuals to produce intensifications of 2C-T-7's visual effects.

One person reported that the tetracyclic antidepressant mirtazapine (Remeron) made him more sensitive to the effects of 2C-T-7.

It is often mentioned that combining phenethylamines such as 2C-T-2 and 2C-T-7 with MAO inhibitors. This is most likely an overcautious statement made out of an incomplete understanding of MAO inhibitors. There are two kinds of monoamine oxidase, MAO A and MAO B. Some MAO inhibitors are non-specific, inhibiting both kinds of MAO. Others are selective for either one or the other MAO enzyme. Secondly, MAO inhibitors can be either reversible or irreversible. The irreversible inhibitors work by chemically bonding to the enzyme, permanently destroying it and making it necessary for the body to synthesize new MAO - a process which can take weeks. Reversible MAO inhibitors do not destroy MAO, but only temporarily bind to it, producing an effect which wears off after a few hours. Not all MAO inhibitors are created equal, and they carry different levels of risk. Even chocolate contains weak MAO inhibiting chemicals. Taking this into consideration, it seems that some MAO inhibitors may be safe with 2C-T-2 and 2C-T-7.

In fact, there is only one case of an adverse reaction from combining psychedelic phenethylamines in the scientific literature. In this incident, a person took the prescription irreversible, non-specific MAOI Nardil an hour after taking a dose of MDMA. Three and a half hours later, the person was admitted to an emergency room. At some point prior to visiting the emergency room, the person drank an unspecified amount of alcohol (having a blood alcohol level of 14mg per deciliter at the time of admission). Combining alcohol with Nardil is itself very dangerous. Doctors gave the patient Benadryl in an attempt to reduce symptoms of tonicity, but the treatment was ineffective. In the hospital, the patient was given care which was primarily of a supportive nature. Three hours after admission, the patient made a complete recovery.

While much of the fear of combining MAO inhibitors with phenethylamines is probably unfounded, there undoubtedly are risks. As the metabolic pathways of 2C-T-2 and 2C-T-7 are not really known, it is impossible to know how inhibition of MAO will affect the way the body handles these drugs.

There have been two reports of combining 2C-T-7 with the MAO inhibitor deprenyl. Deprenyl is a reversible inhibitor of MAO B. The first report was posted to an Internet drug form by an individual who did not specify the doses taken of either drug, but who said that the experience lasted seventy-two hours, describing it as "tough, bearable and non-repeatable." The other is from Alexander Shulgin, who in a private discussion with me reported finding a man at the Entheobotany 2000 conference in Palenque, Mexico, who "was twitching on the grass, with severe motor problems, and who was in a state of obvious physical toxicity." After speaking with the man, it was discovered that he had combined five Blue Mystic tablets (for a total of 37.5mg of 2C-T-7) with several deprenyl pills. Shulgin suspects that deprenyl could block the metabolism of 2C-T-2 and 2C-T-7.

There have been no other reports of combining 2C-T-2 or 2C-T-7 with MAO inhibitors, but if we examine related drugs it may be possible to draw some conclusions. The natural alkaloids harmine and harmaline, found in the ayahuasca vine and in Syrian rue seeds, are both reversible inhibitors of MAO A. Both have been combined by quite a few people with mescaline, producing potentiation. No adverse reactions have been documented. The synthetic chemical moclobemide, also a reversible MAO A inhibitor, has been combined by some people with both 2C-B and MDMA. Again, there were no negative reactions.

Piracetam has been found to potentiate the effects of mescaline. However, one person reported trying piracetam as a potentiator for 2C-T-7 and found it produced no noticeable enhancement of effects.

Chlorpromazine (Thorazine) and other phenothiazines have been found to inhibit the effects of mescaline. Not only do they inhibit mescaline's mental effects, but animal experiments have found that they offer highly effective protection against normally fatal overdoses of mescaline. The effects of mescaline can also be reversed or blocked by low doses of the 5-HT2 antagonists ritanserin and Spiperdone administered intravenously, and the drug meretran may also inhibit mescaline's mental effects. It is very likely that these drugs would similarly inhibit or reverse the effects of both 2C-T-2 and 2C-T-7. Chlorpromazine in particular seems promising for investigation as a possible emergency room treatment, especially in cases where physical toxicity is present.

As mentioned under the section on contraindications and warnings, there is some evidence that insulin may lower the LD50 of mescaline. However, the doses used in this study (5 to 10 units per kilogram of body weight) were many times more than doses used by diabetics. It is likely such a dose would induce insulin shock, and would therefore be toxic regardless of any other drugs taken. While this is most likely irrelevant to 2C-T-2 and 2C-T-7 users, it may be something for researchers to investigate in the future.

In no way can this brief summary be considered conclusive. The reactions described could be abnormal, or due to factors not apparent from the documentation available. More importantly, the fact that nobody has had any unusual reactions to any given drug combination does not guarantee that it is a safe mix. Every person has a unique biochemistry, and even with the most researched and best understood drugs, the possibility of an unpredictable idiosyncratic reaction remains a real risk. Whenever trying out a new drug combination, it is recommended that you start with much lower doses of each drug than you would normally use.

 

 

 

 


Legal Status of 2C-T-2 & 2C-T-7

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Being relatively new drugs, neither 2C-T-2 nor 2C-T-7 have been banned by many countries. While there may be laws in other countries which I am not aware of, it appears that 2C-T-2 is specifically illegal in either three or four countries, and 2C-T-7 in either one or two countries. Many countries have analogue drug laws, however, and in those countries 2C-T-2 and 2C-T-7 may be implicitly illegal. If you are unsure about the legality of either drug in your location, it would be wise to check its legal status with both local and national authorities before coming into possession of it.

Australia

In Australia, 2C-T-2 and 2C-T-7 are covered by the country's comparatively strict analogue drug laws. There has been at least one prosecution in which 2C-T-2 played a part. Unfortunately, my informant on this case did not have complete details. The case happened "a couple years ago," presumably sometime while 2C-T-2 was being sold by Dutch smartshops. A person in New South Wales was caught in possession of large quantities of various illegal drugs. Along with these drugs were also various more obscure drugs, including five tablets of 2C-T-2. Although the primary focus of the prosecution was on the scheduled drugs, according to my informant "it was the fact that there were obscure drugs present that nailed the import case. I don't know how much of a role 2CT2/7 played in this, but from the list of drugs they dealt with this one was probably the most obscure." I was unable to find record of this case in Australia's SCALEplus online legal database, but my informant mentions that he believes the case was heard at the Downing Centre court in Sydney.

Canada

Neither 2C-T-2 nor 2C-T-7 appear to be scheduled drugs in Canada, however it is most likely covered under the analogue drug laws. Under Canadian law, a drug analogue is defined as "a substance that, in relation to a controlled substance, has a substantially similar chemical structure." Using this definition, both drugs could be argued to be analogues of either 2C-B or mescaline. It seems that this law has been enforced at least once. According to a post made to an Internet mailing list, in October, 2000, a person placed an order with a chemical supply company in the United States for 250mg of 2C-T-7. Canadian customs seized the order and sent a notice to the purchaser saying that it had been confiscated. No further action was taken in the case.

Germany

The legal situation of 2C-T-2 in Germany has an interesting history. On October 7, 1998, the Federal Ministry for Health issued a decree titled "Zwölfte Verordnung zur Änderung Betäubungsmittel Rechtlicher Vorschriften", which placed 2C-T-2 (along with 4-MTA, mebroqualone, and two PCP analogues) under the Betäubungsmittelgesetz, Germany's drug law, by express regulation, which is equivalent to the DEA's emergency scheduling powers under United States law. This made possession, import, trade, production, and trafficking of 2C-T-2 punishable by law. This decree eventually expired, but on September 24, 1999, the Federal Ministry For Health issued the "Dreizehnten Verordnung zur Änderung Betäubungsmittelrechtlicher Vorschriften," which went into effect October 10, 1999, and made 2C-T-2 illegal along with 11 other drugs. This regulation also had one year expiration, and so on September 27, 2000, yet another temporary scheduling was decreed in the "Viersehnte Betäubungsmittelrechts-Änderungsverordnung". As with the two prior decrees banning 2C-T-2, this new law also banned other drugs as well, for a total of fourteen, including the tryptamines 5-MeO-DMT and 5-MeO-DIPT. This new decree took effect October 10, 2000 and like the two prior decrees, this one also expires one year after going into effect. 2C-T-7 remains legal in Germany at the present time.

The Netherlands

The Netherlands was the first country in which 2C-T-2 was sold commercially, and it was also the first country to make it an illegal drug. On April 12, 1999, it was declared an unregistered medicine. As such, it is in a separate legal category from scheduled drugs. Manufacture, import, sale, trade and possession of 2C-T-2 are illegal. At present, 2C-T-7 remains legal, but many feel that this is likely to change due to the fact that the government does not approve of the smartshops selling "synthetic drugs."

Sweden

2C-T-2 became commercially available in Sweden in the summer of 1998, being sold in smartshops similar to those in the Netherlands. On April 1, 1999, both 2C-T-2 and 2C-T-7, along with MBDB, BDB, 2C-B and PMMA, were banned in Sweden. This was not done by appending these drugs to the country's normal drug laws, but by passing a new law, "Förordning (1999:58) om förbud mot vissa hälsofarliga varor," which banned the drugs as being materials dangerous to health.

United Kingdom

In 1999, Alexander Shulgin was sent a copy of a letter from the British Home Office to several of its administrative associates which in effect placed all compounds listed in PIHKAL into Class A, Britain's equivalent of Schedule I. Whether or not this law has actually gone into effect remains the subject of some confusion, but it appears likely that both 2C-T-2 and 2C-T-7 are illegal in the United Kingdom. Several researchers, including this author, tried for several months to obtain a complete list of banned drugs in the United Kingdom. With the exception of a few partial lists, all have failed; therefore, it can not be said for sure whether these drugs are in fact illegal in the United Kingdom.

United States

Neither 2C-T-2 nor 2C-T-7 are specifically scheduled in the United States. This does not mean that they are legal, however. The United States has analogue drug laws. Under United States law, it must be determined on a case by case basis whether an analogue drug law violation has occurred. The prosecution must demonstrate that the material in question is substantially similar in both chemical structure and pharmacological effect to a scheduled drug, and that the defendant intended to manufacture, buy, sell, trade, or use the substance as a drug for human consumption. 2C-T-2 and 2C-T-7 could conceivably be prosecuted as analogues of mescaline or 2C-B. There also exist "lookalike drug" laws, under which a person who is selling any substance which is being misrepresented as a scheduled drug can be prosecuted as if actually selling the drug they claim to be selling. If someone were to try selling 2C-T-2 or 2C-T-7 as mescaline they could be charged as if selling actual mescaline.

Currently, no state laws ban either 2C-T-2 or 2C-T-7. Most states also have analogue and lookalike drug laws in addition to the federal laws. These laws may be stricter than federal law in some states.

Several incidents have been reported on the Internet in which law enforcement agents have crossed paths with 2C-T-7. In all but one case, there are insufficient details to be able to verify the stories, and so they must be considered anecdotal.

According to a post made to The Shroomery, an Internet drug discussion forum, a man was arrested in New York state in October, 2000, for driving an unregistered car. He was found with twenty-two gelcaps each containing 20mg of 2C-T-7. The defendant did not tell the police what the capsules contained. Although the police were not able to identify the substance, the defendant was convicted at his trial at the end of November. It is unclear what the exact charges were. According to the person posting the messages, "I heard that he got the 3 years probation for 'dealing.' That really makes no sense. 'Dealing' is not a legal charge." It was also pointed out that the defendant did not make use of a lawyer during his trial, a decision which likely led to his conviction.

The next incident was also mentioned on The Shroomery, in response to the post about the first case. A man was caught in possession of several 10mg doses of 2C-T-7 individually wrapped in aluminum foil as well as fifteen small bags of marijuana. Police kept the suspect in jail while they performed some tests to try and identify what the 2C-T-7 was. After not being able to identify it, police asked the suspect what it was, to which he responded "its just some Advil I crushed up." He was then released, after being charged only for the marijuana.

In January, 2000, a man in the United States placed an order for 15 Blue Mystic tablets from a smartshop in Rotterdam, the Netherlands. This package was seized by customs, and a notice of confiscation was sent to the purchaser. No further legal action was taken.

The fourth incident in which 2C-T-7 has come to the attention of law enforcement in the United States involved the death of Jake Duroy. This incident was described in detail in the historical section of this paper. This is the only one of these incidents for which there is sufficient information to verify the story. No charges were filed against any people in this case. 

 

 

 


Conclusion




This paper has been a fascinating project, and I hope that it will help to characterize two very interesting molecules. However, like almost all research, I feel that it has raised more questions than it has answered. Early 2000, when this project was first conceived, 2C-T-2 and 2C-T-7 were obscure and vaguely defined psychedelics. Today, they remain relatively obscure, but their personalities have been manifested to a much greater degree.

Until recently, 2C-T-2 and 2C-T-7 were seen by many as being mere substitutes for 2C-B or mescaline, having no real uniquenesses of their own. This belief may go a long way toward explaining why neither 2C-T-2 nor 2C-T-7 have been the subject of much scientific investigation.

Furthermore, the identities of both drugs have long been blurred. An interesting lesson in the power of speaking first may be found in this story. Writing in PIHKAL, Alexander Shulgin states "There is a considerable parallel between 2C-T-2 and 2C-T-7, and both have proven to be excellent tools for introspection. The differences are largely physical. With 2C-T-2, there is more of a tendency to have physical disturbances such as nausea and diarrhea. And the experience is distinctly shorter. With 2C-T-7, physical disturbances are less common, but you are into the effects for almost twice as long." Based on this one paragraph, many people have concluded that 2C-T-2 is simply a shorter and inferior version of 2C-T-7. It has to be remembered that every person responds differently to every drug, and that Shulgin's statement is true only for himself and for people he has observed using the drugs. By virtue of being the first person to write about these two drugs however, his opinion has been taken by many as gospel. As more people have used these drugs, it has become clear that Shulgin's results are not universal. For many people, 2C-T-2 is the superior drug. The results of my user surveys ironically show a higher incidence of physical discomfort among 2C-T-7 users. It also has become clear that the two differ not only in side effects but also in primary effects. Most people who have tried both find that they have significant differences in the states of mind they can produce as well as significant differences in the quality and quantity of visual effects. The two are clearly different drugs with different effects profiles. As an added testimony to the power of suggestion, I was amused when I spoke with several people who thought they had tried both 2C-T-2 and 2C-T-7. Each of these people was emphatic about having had much better experiences with 2C-T-7 than with 2C-T-2. All insisted that 2C-T-7 was much gentler on the body. Upon further questioning, it turned out that they had obtained both drugs in the Netherlands, and that the 2C-T-7 they had tried was in fact the mislabelled 2C-T-2.

As Shulgin describes in PIHKAL, new drugs come into the world as blank slates. With each time it is taken by a human, its personality is manifested more and more. Over time, we can form a fairly clear image of a drug's nature, though as with a person, we can never really know everything there is to know. Both 2C-T-2 and 2C-T-7 have grown up rapidly in the past four years. It seems clear that both are fairly typical members of the phenethylamine family, with much in common with Mother Mescaline and their older sibling 2C-B. Each has their own personality, however. Both also remain children, and there remains much to learn.

Several areas seem worthy of further study by those who are better equipped than I for scientific research. First, toxicological studies need to be carried out to determine what the risk factors are. This goes especially for 2C-T-7, which has been linked to some worrisome incidents. It is crucial that we determine whether the death of Jake Duroy and the other reported incidents were due to some unknown pharmacological actions, were overdoses, or were simply freak accidents. Hand in hand with this, experiments to determine the receptor affinities of each drug as well as their metabolic pathways may provide useful information. The unusual reaction to 2C-T-7 described in the pharmacology section by the man taking beta-blocker medications seems particularly interesting, considering that mescaline is suspected of competing for alpha-adrenergic receptors but appears not to interact with beta-adrenergic receptors. Investigating the receptor affinities of 2C-T-2 and 2C-T-7 may shed some light on unanswered questions about mescaline's pharmacology. As for metabolic pathways, I suspect it would be worthwhile to try and compare the metabolism of 2C-T-2 versus 2C-T-7. When comparing reports from users, 2C-T-7 produces dramatically variable responses in different people, with some people having strong trips at 10mg and others barely feeling 50mg. With 2C-T-2, dosages seem to be much more consistent from person to person. This different response has been reported even by people who have tried both drugs. It seems possible that some difference in the way each drug is metabolized could be responsible for this phenomenon.

Another direction worthy of further research, one which I may pursue myself in the near future, would be more user surveys. First, it would be nice to get more data on 2C-T-2 versus 2C-T-7, asking similar questions to those asked on the survey I conducted for this paper. Nearly ten times the number of 2C-T-7 surveys were received, making direct comparison somewhat difficult. This was rather disappointing, as I expected much more response on 2C-T-2 owing to its popularity in Europe a few years ago. Beyond this, I feel it would be productive to try to gather data on more subjective points. Some questions which seem appropriate would include questions on the duration of the experience, the intensity levels of various effects such as visuals, euphoria, panic, and insights or revelations. Again, I feel it important to try to compare 2C-T-2 and 2C-T-7. Casual analysis of published first hand reports seems to indicate that the two drugs produce substantially different subjective effects, and trying to quantify these differences would help to establish what strengths and weaknesses each drug may have as potential tools for psychotherapy, creativity enhancement, or spiritual practices.

Both 2C-T-2 and 2C-T-7 are drugs which I feel have significant potential. As tools for therapy, both seem to promote very insightful states of mind, and allow the well-intentioned user to step outside of emotional entanglements and review their lives objectively, acceptingly, and compassionately. Others report emotional opening and release, and increased empathy with people. Many reports describe long lasting feelings of optimism, happiness, and personal growth following experiences with either drug. Both drugs also hold great promise as spiritual tools, enabling easier access to meditative states. In particular, 2C-T-7 seems to be associated with a very centered state, and the increased body awareness and flexibility it produces seems very conducive to practices such as yoga and tai chi. Both drugs have been reported by users as opening the heart chakra. As with most psychedelics, there seems great potential for the use of both drugs as sources of creative inspiration.

Along with the potential for benefit, both drugs also present potential risks. This seems especially true for 2C-T-7, although this could be a distortion of the facts caused by a much smaller sample size of 2C-T-2 users responding to the surveys, or a reflection of the fact that many 2C-T-2 users seem to be more cautious and educated than many 2C-T-7 users. While there have been no significant incidents reported involving 2C-T-2, it is better to be too cautious than not cautious enough. Used in moderation, both drugs seem to be quite safe. While there have been several serious incidents reported, we need to remember that this represents only a tiny fraction of total uses. There have been fewer than ten incidents of concern, out of thousands of total uses. This record looks even better when considering some of the reckless dosages taken by many people.

The biggest risk of course is that the risk factors are not really known. Until more research is done, it would be wise to proceed carefully. People taking 2C-T-2 or 2C-T-7 should avoid mixing them with other drugs; if someone does decide to try a drug combination, it would be a good idea to start with a lower than normal dose. People with potentially life threatening medical conditions should avoid taking 2C-T-2 or 2C-T-7, or at least start with very low doses.

The most common cause of bad reactions to any drug is taking too much. This definitely applies to both 2C-T-2 and 2C-T-7. Many users are careless about dosage measurement, using ineffective techniques such as the graph paper method or even just guessing. Large doses of either drug, but particularly 2C-T-7, can lead to states of extreme confusion and detatchment from physical reality. This can lead to panic reactions, toxic psychosis, and physical injuries due to being unaware of one's surroundings. It is even possible that with a large enough dose, death due to overdose toxicity could occur. In my opinion, many people who are taking such large doses are missing the point of these drugs. People taking extremely large doses often mention that they are seeking powerful visual effects. While 2C-T-2 and 2C-T-7 can both be extremely visual drugs, I don't feel that these are the primary focus of the experience. I feel that the primary strength of these drugs lies in their effects on the thought processes and emotions, subtle effects which are optimally experienced in lower dosages than are required for the overpowering visuals. I believe that the state many of the visual seekers are trying to achieve are in fact mild overdoses, as physical discomfort can become quite pronounced at such dosage levels. While I firmly believe in the right of these people to take such doses if that makes them happy, they may wish to consider turning to drugs such as DMT which produce intense visuals in more reasonable dosages, with much less physical side effects. First time users of either drug should limit their doses to 10 to 15mg orally.

One other suggestion for minimizing bad reactions is to take these drugs orally. Other routes carry much higher risk of accidentally taking too much, due to the much smaller dosage ranges involved. Although a very popular method, snorting these drugs dramatically increases the variety, intensity, and duration of side effects. Of all the bad reactions which have been reported, whether physical or psychological, the overwhelming majority involved cases where the drug was insufflated. In addition to the much smaller dose ranges involved, the rapid onset of effects can take many people by surprise. Rather than a serene and gradual two hour ramp up when taken orally, snorting it can result in a very sudden and rapid catapulting into an extremely altered state of mind. Oral doses offer fewer side effects, a wider margin of error in dose measurement, and a gentler transition into the experience. In addition, there is none of the intense pain nor the potential for damage to the nasal passeges which are present when snorting them. I strongly discourage taking either 2C-T-2 or 2C-T-7 by any route other than by mouth.

I feel one of the most important things people need to realize about both drugs is that they are still experimental drugs. In the end, it is very likely that research will show them both to be very safe and useful drugs - but until that research has been done, it is important to be respectful of the experimental nature of 2C-T-2 and 2C-T-7. It is also possible that research will show them to be dangerous drugs which work very differently from mescaline. Anyone considering using them should keep this in mind and not use the drugs recklessly. Use low doses, and take long breaks between uses of either drug. You can always take a higher dose next time, but you can't go back and untake some if you take too much and have a bad reaction. Avoid putting these chemicals in the hands of people who you do not honestly believe can use them responsibly. I firmly believe that people have the right to be irresponsible and self-destructive, but at the same time I also believe that those of us who know better should not go out of our ways to help them. The right to be stupid can not and must not be hindered if we are to live in a free and civilized society. That doesn't mean it should be encouraged, however.

Chemistry has given us two very interesting chemicals in 2C-T-2 and 2C-T-7. Both hold great promise as tools to benefit mankind. Let's learn what we can about them, and perhaps then we may learn from them.


This research paper has been brought to you by the letter Þ and by the number 42.

 

 


2C-T-2 User Quotes




General

I decide it's a good time to go out, so I take my bike and go for a ride to a nearby hill. From there I watch the beginning sunset while I have a live tape from '92 with Sonic Youth playing in my walkman. After 30 minutes I walk down the opposite side of the hill, and find it to be full with Trifolium Pratense. I suck the nectar from a few of them, and I am pleasantly reminded of how I used to do so when I was a kid. I admire the purple and green hillside for a while, before I walk down to a landing-stage by the nearby lake. I spend the rest of the sunset sitting there in a yoga position meditating, admiring the sun and the refelection of it as it disappears below the horizon. I am experiencing something very religious and transcendental. By focusing at a point a bit further away, I can get the illusion of the landing-stage moving, instead of the water flowing.
-Anonymous, 24mg orally

At one point I sat down on the ground, legs crossed and with a strong feeling of PERFECTION. I felt to be in a state I could dwell in forever, the euphoria and feeling of having reached the maximum of what I could be were incredibly strong. The immensity of my ego at the time bordered insanity. I asked my friend to take a picture of me while in this state, so I could check later how attractive and perfect I appeared to the outside world.
-Anonymous, 24mg orally

I was enveloped by a feeling of warmth. I was covered up with a warm blanket which felt real nice. my body felt like it was suspended in air and beautiful images danced in my mind. bright beautiful neon colors twirled and shot across silver backgrounds in time with the music. I was inside of a shiney silver walled spaceship watching pentagons and hexagons morph into different shapes and colors. laser beams of neon were shooting across the room. I then saw myself outlined in neon in a completely black room. before you knew it I was holding a laser-tag gun while standing on a rotating platform. once again let me emphasize the warmth I felt. never once did I feel cold. every now and then I would catch myself smiling and kinda giggle to myself because this felt so good. not good like an MDMA good but good like I liked the place I was in and was content with what I was seeing. I felt like nothing could harm me, like I was safe from the world.
-Embrace, 20mg orally

After two hours I feel like a intense psychedelic is knocking on my door, but he never comes in. It touches the surface. Dept and colour are different. The humorous substance does not allow me to stop laughing. This ceiling seems miles away, letting me drift into deep spaces, but as soon as I forget to focus, I am back to baseline.
-Horus, 8mg orally

Some pressure on my head for half an hour. Sitting was better. I wondered where this would go and started to smile. The smile transformed into a laugh until my belly hurt. Then I was energy. The walls danced with me. So was anything else. Music was good to me and I was good to the turntables. Talking was nice but I had no interest in the sensual efforts of a woman. The experience lasted 7 hours in total. No after effects. This is a very controllable substance which gives the visuals without losing yourself in the experience.
-Horus, 20mg orally

Visual effects reached extreme proportions. Periodically, my entire visual field would be "washed" by "waves" of color - pink, green. The size of the letters on my screen would constantly shift between very tiny to gigantic. I would see complex fractal like fields and vortexes appearing in my desk and monitor frame. Colorless (yet somehow visible) astral vines would periodically wrap around things. My floor tiles were swimming. I would see trails from stationary objects. I also experienced auditory effects. I was hearing voices constanly, which I think were conversations in adjacent apartments, and so represented sensory enhancement and not hallucinations. I was extremely confused, and the fact that my friend was unconscious didn't help to lessen that confusion. Periodically I went to check if he was responsive, occasionally he would answer incoherently. I decided to do some GHB to mellow things out, and took 2.5 grams. This seemed to lessen the confusion, but had no other noticable effects. The visual effects seemed to increase gradually, hitting a peak sometime around 1:00AM. At no time was there ever any real sense of panic, no real fear... just overwhelming confusion. Confusion to the point that I felt I was going to lose my mind - but not really. At one point I said on the chat room "I think I am [freaking out] and just don't realize it," followed by "I think this kicks ass... that or it sucks... one of the two." It didn't take me too long to decide on the former.
-Murple, 24mg orally

I had a really amazing trip! I think this was almost more memorable than my 24mg experience. 1:00-3:30AM was the peak. I had all kinds of nice visuals, similar to mescaline or 2C-B. Temporal dilation was extreme, time moved at a crawl. I had very altered mental processes, a feeling that my thinking was moving throught these strange winding logic "tunnels". It seemed as if I were moving through these tunnels, gathering insights on the way. One bizzarre moment happened during the peak as I was laying down on my bed. I found myself unable to think in English, or recall any English words. Instead, I found myself thinking in German. This was very odd, since German is not my native language. The overwhelming feeling I had through the entire trip was "Everything is OK, and everything will be OK." I came away from the whole thing with a nice optimistic outlook on life.
-Murple, 16mg orally

Wonderful visuals, tracers were incredible, Such a great sense of well being. I live in MS and it never snows here. But that night it snowed a decent amount. The atmosphere was incrediable. It felt like the universe revolved around my soul. This must be the greatest drug I have ever tried.
-Tabitha Rollins, 28mg orally

Visual Effects

At one point, I was watching a pattern extremely similar to some of the patterns you might see using the 'Elements' eye-candy software, when all of a sudden out of the depths of my vision letters started to race by, in big sweeping movements, sixties/seventies-like lettertype, bright neon-colors, and just... letters, and numbers, and comma's and hyphens, questionmarks, exclamationmarks, periods, the works. Again I just laughed in amazement. I kept telling my friend that I had never imagined I could hallucinate the alphabet. It was hilarious.
-Anonymous, 24mg orally

The stars twinkle and small rays of light bounce between them and around the sky. The trees exhibit strange fractaline motion, moving and twisting in the night sky. The sky is a strange purple color. I remember very powerfully that the contrast of green on purple is quite beautiful and how I wished I'd had a camera to capture the effect. Of all my experience with psychedelics, this experience was absolutely the most visually spectacular, though I believe the clarity of thought acheived is comparable to that of acid or mushrooms.
-Anonymous, unspecified insufflated dose

At one point while I was dancing the shapes I was watching suddenly started taking on known forms, and I was quite happily amazed when I realized I was watching myself dancing from a point to my right and about nine feet up in the air, somewhat distorted and in strange, psychedelic colors, sure, but it was definitely me. I told my friend I could see myself dancing, he asked me 'where?' and I tried to point myself out. Which is very confusing if you're watching yourself! I pointed forward, because the 'vision of me' was in front of me, but then I *saw* myself pointing in some other direction. I moved my arm around untill I saw myself pointing directly at myself.
-Anonymous, 24mg orally

The first time on 2C-T-2 I was listening to a really hard acid CD and I visualised an orgy. It was so real that when I woke up afterwards, I was sad that I had unprotected sex. *That* real.
-Anonymous, 16mg orally

Mental Effects

Both me and my friend (we had tripped together a couple of times before) had a strong feeling that our trips where connected and even somewhat intertwined at some levels, and most things that I experienced, he experienced as well (and vice-versa, of course).
-Anonymous, 24mg orally

2CT2 can be used a tool to search inward and can help someone see themself as they really are, and not how they think they are. ...You can look at yourself with honesty with shame and see way to help yourself.
-Grotto

Very therapeutic material. I had complete introspective look at my life and the lives of others. Came out of it all with more confidence and exceptance.
-Taro

The complex yet subtle and unusual emotions [with] higher doses can be hard or heavy even though they feel to be from deep within and gentle, can be overwhelming, I've fled on a high dose from them into a lot of cognating [regarding] emotions -- recommend starting easy for best benefits, enjoy the subtlety. ...strong desires for telepathic communication.
-Tigger

I had been slightly depressed for a period of time, but dealt with some of the underlying factors, and felt I was on the right track, but I was not completely free from conflicts and nuisance. Suddenly I felt this massive emotional release, I was no longer poisoned by the shame I had been feeling, and the remaining guilt didn't feel very heavy to carry on my shoulders anymore. Actually, most of it fell off. I no longer blame myself for being the one who I am, sure I do a thing or two that is not very good, but those are mistakes, and mistakes can be corrected. With this new insight I felt that I found a whole new energy to take on the world with. ...Other feelings of deeper acceptance were felt in connection to being part of the great cosmic game and the feeling that everything was going to be alright sooner or later. I enjoyed touch, and had that special cosy, warm feeling inside, centered in my chest and through it, it was beaming in and out of everything. I thought about DAMP (ADD, ADHD) and how some of the symptoms are part of my personality, and that I really would not like to be 'cured' by whatever might be available. I'd rather see a society which is adapted to different types of personality than one where you have to adapt the people to the increasingly absurd state of the western world.
-Anonymous, 24mg orally with 10mg 2C-B

By the fourth hour and onward we had ruthless clarity in communication. Each of our minds was like an impartial and dispassionate judge or shrink, no messing around, no fuss, no emotions, just pure brilliantly clear exposing of whatever needed any clarification. No fear of hurting the other with truth. Just laying it all out. We covered a vast territory, all aspects of our relationship to each other, to friends and clients, everything came under perfect scrutiny. "We decided that this might be a good thing about once a year, to take stock and make sure that nothing is left hidden or unresolved. I was actually surprised how much work can be done just using this laser clear mind. I tend to feel(!) that involving the emotions and the body itself are crucial for inner work. So, got one of my little myths popped!
-Andrea, 20mg orally

Slow coming on, took an hour to feel anything at all, and 2 hours to get really into it. Then a visit to all of my current issues, becoming aware of the feelings for each issue yet oddly more like thinking about the feelings rather than experiencing them. Uncomfortable, cuz the issues are uncomfortable. My partner did likewise, but not much discussion. Finally out of issues. Then 3 - 4 hours of intense discussion of all aspects of our lives and relationship. Ayn Rand would have been proud of us! A very clear laser like objectivity, deeply truthful, cleansed of all emotions and yet in no way obscured. We talked about EVERYTHING. ...I had done an acid journey a couple of weeks earlier, with a number of incomplete processes as a result. 2ct2 cleared these up most emphatically.
-Hara Ra, 24mg orally

Negative Results

I had heard from another friend that snorting the stuff was fabulous, so I decided to try it out. We each take two bumps, roughly the size of the end of a pencap. It burns like hellfire for half an hour or so. ...It burns like sulphuric acid and the smell sticks with you for hours and hours. I think the smell contributed the most to the nausea.
-Anonymous

I can remember trying to jerk off, taking my clothes off, running through the entire house naked. I can remember going to the cellar, naked, spotting some old TV-Guides for nude women. I can remember going up and down the stairs again and again. I can remember going to the toilet for a shit, wiping my ass and looking at the toiletpaper. I can remember going to the toilet to do exactly the same again, after one minute. I was just completely fucked. Music did not compute, internally. I was listening to a mixed CD, but the songs did not blend. Instead, when the next tune started playing, a new world would start in my mind. I got dressed, then undressed myself. I tried to jerk off again but was tripping too hard. Got dressed again. Got in bed. Out of bed. Onto the sofa. Watched some TV, tried to jerk off again (to a butt-and-thighs shaper). I got cold. I felt miserable. I was past the phase "Oh God I want this to end". I was past anywhere I had ever been. Yet there were *no* cool trippy effects like with 'shrooms or LSD. I did not enjoy the trip. At T+ 6:00, I think, I got dressed again and made myself a stawberry-jam sandwich. I put on my coat, unlock the door and got out. I only walked for 2 minutes, then got back in. Locked the door again. Took off my coat. Went to the toilet again. It was hell.
-Anonymous, 32mg orally

The body load is extreme. 2.5 hours of nausea is not made up for by the high, and no significant insight seemed to come from the high.
-Purlah

About a half hour in, without any warning whatsoever, I had to vomit; shortly after that, I was feeling fine again. A half hour later I was finally starting to feel the effects. The effects were mostly visual to me: the room became very soupy, and I was able to play with the trails in the air in a very tangible way. Psychologically, meanwhile, I wasn't particularly stimulated by the experience; it was weird in a very undramatic fashion, but provided no particular 'content' that I could find.
-Scotto, 40mg orally

Out of all of the sulfur compounds I found this one the most uninteresting. ...I went ahead and pushed the dose to 32mg and had some very significant side effects (sweatiness, shakiness, jaw clenching, restlessness...sympathomimetic overdrive) and no increase at all in psychedelic or other effects. ...This one just wasn't that interteresting for me, it seemed to "lack" something... but i'm not sure what.
-Don Carlos

Drug Combinations

I laid there with my eyes closed and saw fantastic images passing before my eyes. A strange looking guy playing an acoustic guitar, wearing sunglasses, and in his sunglasses there was a reflection of himself. Cartoonish images that reminded me of the Beatles movie Yellow Submarine and the animations in Monty Python's Flying Circus together with strange looking letters were floating around in my consciousness. I felt the music swirl around my head, it was pure synaesthesia. I no longer smelled, heard or saw anything. I just felt it. I was one with pure cosmic bliss, and every other psychedelic cliche you can think of. I felt myself being transformed into warm jets of energy that were beamed out into the universe as one and all.
-Anonymous, 16mg orally with 15mg 2C-B

Im in a really interesting space. VERY nice. Much like mescaline, indeed! Similar to my San Pedro experiences, but milder on the body. I can feel the 2C-T-2 in there, and the MDMA... but theybe all melded into a nice whole. Colors stand out in razor sharp clarity. Very vivid, yet natural. Mescaline-type visuals overall. ... Wow... this has only been 10 minutes? I must be experiencing some pretty heavy time distorions. Laying down in bed with my eyes closed I had some great closed eye visuals. I see things flitting around the corners of my vision with open eyes. Colors are ultra-crisp. I see little fractally overlays over alot of things. Shimmery and spider-weblike. Similar to what I've gotten from mescaline. Sounds of crickets outside are amplified and reverbate - natural music. Physical sensations are amazing. Not quite like mescaline or MDMA but about half way in between the two polarities. I can feel the MDMAishness fading some, but the 2C-B and definately the 2-C-T-2 are going strong still! In some ways theres a GHB-ish feel to the physical aspect. This is very interesting... and nice.
-Murple, 4mg 2C-T-2 orally with 10mg 2C-B and an unknown dose of MDMA

I once smoked [cannabis] while the plateau was ending but still quite strong, and the only way I could describe this to a companion was, "THIS is what they mean when they say, 'this is blowing my mind'". Time was extremely slowed and motion had a beautiful, blurred fluidity.
-77k

I am just along for the ride, not in control. Unfortunately I am unable to bring much of the experience back. The next time I check a clock it is 2 hours later and I'm left with some vague impressions. I am not the same person who went into this experience, but I can't pinpoint the difference. Confusion reigns. No conscious answers to my questions. Setting requires my attention on occasion, distracting me. I go in and out of the k state for another hour or so, and am mostly back to baseline at the 4 hour point. Sleep comes easily. ...I'm glad I did it, but probably wouldn't repeat the combination.
-Ouro, 6mg insufflated with 70mg ketamine

...the dosage was not high enough to fall into the K-hole but combined with the 2CTC2, it allowed you to move in and out of one reality to the next dimension and back in consciousness. Often when taking K by itself, you come out of it like you had a major dream but with 2CT2, you are able to integrate in the different states... further, your motor senses are not completely knocked out, you can have a good trip and physical pleasures combined.
-Philip, 8mg orally with 50mg ketamine intramuscularly

As with every other psychedelic, nitrous and 2C-T-2 combine beautifully. I melted into my furniture while my visual field swirled and rippled. Amazing.
-Anonymous, 16mg orally with nitrous oxide

Aftereffects

Undefinable emotion lingering for some time afterward, deep and possibly sad but bound to joy, best word i can come up with is soulful - aware of connection to other feeling beings yet more in touch w/individuality at same time, sometimes an ok lonliness leading myself to myself for companionship or somethin like that.
-Tigger

A general feeling of accomplishment and clarity. Much like that after dealing with a very painful headache. When it is gone, the world seems a bit different.
-Deuterium

Long Term Effects

I've got the feeling that I can hear more detail/structure in music. Emotions seem to be more intensified (in an enjoyable way), at some times. Am enjoying lfe more.
-Barium

Learnt to look upon our pursuit of wealth and social status, see ourselves great and small at the same time and smile.
-Skydancer

Better outlook on the world... 2c-t-2 makes me look at the world through a different set of eyes, which sees the magic hiding in every nook and crannie.
-Señor Coconut


 

 


User Quotes 2C-T-7




General

I was feeling emotionally cut off and sad, and wanted to explore these feelings more deeply. Physically, nausea came in and out in waves, but not much gas and bloating as experienced before. Violent vomiting at +2.5 hours. This put an end to the nausea. Was able to talk to my love, and apologize for my behaviour as the Robotic Asshole. Deep sobs washed through me. I saw myself with a heart softened by sadness and compassion. I'm grateful to be able to put a crack in The Robot's shell and give the Human a little room to move.
-Anonymous, 40mg orally

Very intense come on. I think that going from ground zero to Neptune in the space of ten minutes may be too much for me. Next time I'm swallowing it. Had to concentrate to keep under control. Hardcore stomach rats and shortness of breath. Head pressure makes me want to pop my ears. ... Visuals are kinda mild. ... Very heavy body load. Stomach cramps and shoulder muscles. I puked a little. Seemed to help for a minute. I got my brains together and decided to take a walk to the liquor store. A little booze to take the edge off. ... Everything on this stuff is almost identical to LSD. Same metallic taste when you lick your lips. Same kind of visuals. Shadows and trees waving. Spotlights in the sky. Red and blue shadows. Horrible acid like stench coming from my pores. Walking around helps a lot. It gets my mind off of the cramps. I find that my mind is clear so paranoia does not make much sense. I get myself some vodka (the only civilized drink) and a few swigs seem to help my stomach. I walked around for about an hour. I am cheerful and I know everything will be ok. Five hours later the visual effects mostly gone but still nice trails. ... If I take it again it will be a (still) lower dose. Not sure if it worth the body load.
-Anonymous, 8mg insufflated

Walking outside in natural surroundings it was obvious that this compound is highly visual. However the sort of visual effects it produces are quite unique, though difficult to describe. It seemed as if our entire field of vision was alive and pulsing with energy. The grass appeared hyperreal and computer generated, not unlike the habitat of the 'Teletubbies'. Anything that we looked at would seem to dissolve in multiple images of itself. As the drug effects grew stronger these visual transformations reached such an intensity that ordinary scenes were rendered unrecognizable and we found ourselves forgetting where we were- a sort of micro-amnesia. Everything appeared to glow with a strange metallic sheen as if newly made and there was a keen awareness of energy flowing through everything. One curious effect was the tendency for everything to appear as if in a picture, as if it was all perfectly composed, yet even the slightest change would produce another quite different but equally perfect vista. Another strange effect was the tendency for the environment to look squat or shrunken, so that trees even when quite tall appeared like miniatures. But while the landscape appeared shrunken birds flying overhead seemed the size of jumbo jets. However it was difficult to look up and our eyes were continually drawn to the ground and it seemed that we beheld the world through a fisheye lens for the first four hours. At times these effects seemed overwhelming, certainly 2CT7 is a major psychedelic far stronger than 2CB. The peak effects occurred within the context of extreme time dilation and the first two hours seemed to last forever. Our sense of space was similarly distorted and it was impossible to judge the distance of objects and they would appear alternately close and distant. One persistent impression was that our 'auras' or energy fields were somehow crackling with a strange energy and we became worried that other creatures- both animal and human- could sense this. In fact we became convinced that we might be the victims of an unprovoked attack by a dog or a duck. Whenever we encountered straight people we felt highly uncomfortable. Although powerful our thoughts were not as disrupted as they might be on a comparable dose of LSD and communication remained easy throughout.
-Anonymous, 5mg insufflated

Allows me to become very introspective, see my life with a clarity that I cannot find without 2ct7. There is also a strong erotic component that is difficult to describe. At higher doses than are the norm for me, the visuals experienced, both open and closed eyed are fantastic. The visuals could be upsetting to some people, but I understand them, and look forward to them. There is a tolerance component also. The use of 2ct7 more than one time a week has a much diminished effect on my body/mind.
-been

2C-T-7 is a valuable psychoactive; in my experience it brings on a very calmed, happy state with exciting visuals and extremely increased focus and imagination.
-Bender

I'd say there are chemicals that I'd class as viable to "muck about with for fun" but I have earned a deep respect for 2C-T-7. It was quite intense and I feel that I learned a lot. The experience redefined my landmarks for pleasure and endurance, but I would hesitate to recommend it to someone who wasn't comfortable with having to hang onto reality hard if they need to.
-BigTrancer

My one oral dose of 25mg resulted in extremely intense effects including ego dissolution and severe tactile distortions and effectively immobilized me on a bed for over 9 hours. Insufflated dosages in the range of 5-10mg only produced threshold effects. 2C-T-7 is the only compound I've yet tried with which I have such extreme sensitivity. I have an average response (perhaps even mild insensitivity) to all natural and synthetic tryptamines I've used thus far.
-Clandestine

A buoyant sensation begins to thermally maneuver and spread itself throughout my body, outward from my heart and through the interwoven network of cells until it finds release through the skin. I am warm physically and feel the psychic tension of everyday reality dissipating like so much steam from a kettle. A simply delicious elatedness washes over me, not so powerfully and overwhelmingly as with MDMA, but smoothly, effortlessly sly creeping passion flower. ... Synesthetic fluctuating sounds emerge surreal and psychosomatic structuring realigns itself adroitly. We are all the grand conductors in the orchestra of our own lives, but we are more: we are each the audience in whole I feel the musical quality of the very air we breathe, and move my hands in concert with the pulsing rhythm of the cosmos.
-Diamond Joe, 35mg orally

When on 2C-T-7, it feels as if i'm possessed by a spirit. This is not a "body high", but rather a presence in the body. I'd call it enjoyable.
-DJ Furby

One thing I think very positive about this substance is its sensual aspect. Hot, passionfruit-style herbal teas and quality wines are extremely aromatic and pleasurable to drink. And, of course, touch is very enjoyable, but in a rich, sensual way, different than MDMA. Acid and shrooms primarily affect visuals and sound, but this substance seems to take visuals, sound, and touch, and just meld it all together. Sound can become touch can become visual, and it's very pleasant because it's controllable. I feel like a wizard because if I concentrate, I can make the wall meld with the floor a little bit, and if I concentrate again, it will go back to normal. At any time, I feel like I can somewhat throw off the effects to become 'sober', which makes 'bad trips' nearly impossible. Anyways, I give it two thumbs up, but I'm still experimenting.
-Euphony

Deep thoughts, dreamy, almost sleepy if I just lay around. Moving feels good. Noticable red-blue separation visually, but nothing I can't control. Thoughts could be examined in great detail very quickly. It was different from the spiralling thoughts of LSD. It was layered. Everything had multiple depths to it and each layer could be discerned and examined. Extremely impressive.
-Flotsam, 30mg orally

I've tried it at 9mg's and twice at 24mg's. I found the 9mg trip to be very rewarding, but not visually. I prefer this level, it's like meditation then. The 24mg trip was visually interesting, but side effects got much worse.
-fr33, two oral uses

Closed-eye visuals are more intense than open-eye ones. 2C-T-7 just makes me want to sprawl out on a bed or couch and not move. It's also a very social drug, it makes you want to be around people. But I wouldn't suggest doing it around people who might hold silly things that you do while intoxicated against you because it does lower your judgement and conscience. Very fluffy, floaty, sparkly trip.
-grasshopper

First psychedelic I've done in 30 years. Strange colors, feelings of power, no insight during the trip but tremendous reflection afterwards (for weeks), strong sexual rush. Inability to think lucidly. No, aha! I feel stupid during the trip but am returning thinking I just don't know my way around yet. It was a big step to take it, as I had been drug free for 10 years. But as I remembered, psychedelics aren't like addicting recreational drugs. This drug is a psychedelic akin to mescaline or lsd, is useful and though interesting is not for entertainment. It's usefulness however will win converts and praises which will ultimately lead to its illegality.
-Hill

Open eye visual imagery is remarkable, color intensification beyond any other experience. I did not find it particularly spiritually uplifting, compared with say ayahuasca or psylocybin. A large oral dose caused extreme confusion and dissasociation. Moderate doses useful for problem solving, empathy, insight, creativity, music, recreation, intimacy. ... Insuffilation results in much greater discomfort, in nasal passage, and in regard to jitters, tachycardia. Reasonable oral doses were without significant side effects. A large oral dose caused short lived nausea and vomiting. Oral administration has been the best way to reduce side effects. Smoked cannabis helped with nausea.
-iasion

Its easier to slip into dark/disconnected thoughts then with other hallucinogens. Set and Setting are easily more important then when on LSD. With 2ct7 most experiences come from deep-within so stable surroundings are important. Conversely, exterior situations are much eaiser to deal with then when on LSD due to less external (social) distortion. Visuals are easily more intense then LSD's, but can be cut through if so desired. The long-term effects are overwhelmingly positive. I've had more breakthroughs after recovering from my 2ct7 trips then I've had in many years.
-jalad kleen

I loved this experience. I saw visuals, colors and patterns, almost instantly with my eyes open. I heard music and there was none playing. Shocking! The sound of my own breathing and an air conditioner running. I became afraid for myself, I imagined that I would never trip again not even acid. It was like light speed backwards, to the very core of "I". It was so fast. There wasn't even an inkling of a chance of fighting it--that seemed to only make me wretch. Everything real or imagined ran away FROM ME! The world fractured like black glass. Soon, I knew not if my eyes were open or shut, but infinity became apparent. God was a flat plane over which "I" floated. The disassociation from self was so great, that my body seemed to be asleep while "I" watched over it. I thought I could die, but it wouldn't stop and I'd be "There" forever; so I decided to live while simulaneously deciding that I didn't want it to stop. I figured I WOULD trip again, just not this stuff. Soon, I was so thankful to be "There" I knew I would do this stuff again, just don't know when. It seemed as if those who had ever been "There" before me were still "There". I imagined that if anyone ever went "There" after me, that "I" would still be "There" as well. I experienced what I interpreted to be ancestral memories, entering a spirit world much like that described by users of peyote. Just as my ancestors were talking me through it, just as I grew from a cell to a cave woman to THE woman of the year 2000, I was shot out of the galaxy--quasar, pulsar--far, far away. It was as much like being born as I can remember! But with the most spectacular visuals (much like mushroom visuals)you never or ever saw. How refreshing! That was the first thirty minutes. After about an hour I could speak about what had happened previously and listen to music, much like a regular mushroom trip. It lasted for nine hours with another three of visual distortion and sublime afterglow. I can tell you that the intensity of snorting 35mg of the stuff is very much like dying and going to hell for a brief, yet extended period of time and the shock is so great it seems you might never live again! After that it is heaven, but it comes on so intensely--we shouldn't be allowed to insuffilate such a large dose. Possibly, this intensity is unnecessary. When my boyfriend and I did it, we were alone and snorted it only about four minutes apart. There was no one babysitting us at all when we took it, no one told us we would need a sitter, and we spent the whole night with our front door unlocked, rolling around on the floor--he got rug burns from crawling around in his delirium!
-Jellymaze, 35mg insufflated

I took too large of a dose in July, which left me confused and a little worried. All my vitals were normal however and I was fine the next day. I haven't felt the shoulder tension that I felt in July again, but these days I tend to snort it. I start work early in the morning and if I'm going on little sleep I take it to stay up (on occasion). The mild doses are very pleasant [in my opinion]; just a slight dialation of the pupils and a clear lucidity. There are some attitude changes also. Similar to the empathy felt in MDMA yet far less intense. Definitly no blissful emotions like with MDMA. I've started snorting it because it's more economical and it takes only 20-30 minutes until the onset. Orally it takes about 1 1/2 hours. Not a party drug but recommended for reflecting.
-macinley

I started feeling weird almost instantly but it took another good 20 seconds after i finished injecting for the real rush to come... I took 50 mg orally not that long ago and i thought it was intense enough for me but belive me those little 5mg were 10 maybe 100 times stronger than that. ... It was so intense that my mind still felt very clear as i was tripping like mad. It was exactly like if i had been thrown in the middle of someone else's trip, really. I got really scared at first because i was not used to be thrown in a trip that intense in such a short time. Actually, the very intense part only lasted 10-15 minutes which means i had very little time to adapt and if i ever do it again i'll certainly not lose part of these precious minutes being scared. ... It took me another 20 minutes to feel down enough to smoke a little, then i took a quick shower and now i am writing this about an hours after injection and i still have very nice effects similar to what i could expect from a 40-60mg oral dose.
-manda, 5mg intravenously

I sampled the material a second time at a low dose (5mg) during the recent blizzard which hit the east coast in january. This produced a very joyous, childlike state in me, I went for a 2 mile hike out in a driving blizzard, and had a great time. There was definately a strong visual component even at this low dose... the snow falling looked like clouds of shimmering diamonds. The light from street lamps refracting off the snow drifts gave the impression that the world was covered in huge mounds of purple and pink ice cream. The cold didnt bother me at all. I walked down to a local park where I stood in awe at the snow covered trees. I threw snow balls into the air. I got home, took a hot shower, and made myself some curry. The trip lasted a mere 6 hours or so, but was very nice...
-Murple, 5mg orally

Ok, I know some will say it ain't so, but my curtains are revolving tubes of vertical colors. It isn't a huge visual, and it takes some staring, but it is there. This substance gives a secure and warm feeling. In a dose of 2mg it might be an excellent antidepressant. The edge of psychedelia is there even at 4mg, although I have heard it isn't active below 10mg.
-Oldtimer, 4mg orally

I think having a meal previous to ingestion is a good thing...it slows down the onset of the experience, giving you more time to adjust physiclly perhaps - seemed like this helped with the nausea, empty stomache trials yeilded some faster onset but more tummy problems. Helps combat dehydration a bit too. Drink lots of water...keep physical activity mild or well monitored...I think it raises ones respiration quite a bit and you tire more easily because of that. Based on some group experiments...lower dosages are better for dancing. Usually leaves you with one good thought to take home with you. Much less mental warping than LSD. Perhaps move visual than LSD.
-Sage

Wandering to the beach (I live on the coast of CA), I felt as if everything happening around me was happening just for me. Dogs joyfully chasing sticks, putting on a fantastic show. Pelicans diving into the water at just the right moment. The oil rigs would release a flame of excess gas, lighting up just for me. The truth is the that things were happening around me that I had never seen before, and they were happening at just the right time. I was so happy, because for a period of about an hour at the beach I felt that every thing going on was perfectly timed, done just for me. Back in civilization, my interaction with other people was being carried out in a Zen like fashion. I was fully stimulated, but also in a very special head-space. This orientation was so relaxed, any question directed at me was instantly answered. My feelings about other people were enhanced as on ecstasy, and I feel my confidence was related to my conviction that nothing in the world that was going on was wrong in any way. I had a tremendous sense of purpose.
-Skip, 12mg orally

It may emhasize contradictions inside your mind, but it has positive MDMA-like feeling with allows you to process these issues. After the experience I usually get feeling that "pieces of the puzzle" in my life has been put into their places. It helps you to find meaning of different issues in life and find the connection between them. Sometimes the experience is filled with agony and difficult to escape the feeling. I have found out it's best to take the drug rectally. It causes less nausea and you can avoid the burning in the nose when snorting. Onset is more rapid, after 1h the effects are noticeable. The dose can be 30-50% smaller compared to dose taken orally. Medium level experience causes distorted feeling of your own body, it feels like you physical form is something different than normally. Some unexperienced users have found this very frightening.
-Sk8guy

This is probably my favorite psychedelic, it gives great visuals, and has an MDMAish quality to it. The overall feel is very positive, definitely in tune with the spiritual world, on the high oral dose there was a definite sense of "something else" out there and that i had nothing to fear. As shulgin said....Green Light!
-spiritinthesky

Visual Effects

The bathroom is incredible. The shower curtain is like a work of 3-D art, enhanced with flowing colors. The toilet paper designs bubble in and out as if boiling. The floor swirls all around, and even the white walls bend, and are covered with bright little specks that fly around.
-Gumby, 60mg orally

The world around me eventually took on more movement then has for any other psychedelic trip ever before. Incredabale swimming, inverting, kaleidoscopic motions, always being overwhelming colorful. I was in a darkened room with the computer monitor, and at times the television, lighting up the room. The overhead light was too bright, unpleasant, and overwhelming to keep on. Eventually, the outer world became so changed, it was unrecognizable. It is truly no exaggeration to say I could not see the normal world at the peak of the experience, and I had to feel my way around.
-MGSeeds, 50mg orally

The visuals are very disturbing to me. It is a repeating hexagon pattern, with each hexagon made of three diamonds (like a cube viewed with one corner dead on) with a pair of dots in each diamond. The pattern is ugly and really really scares me. I can only handle it at low enough doses that it is very subtle.
-Miranda

Mental Effects

I find 2CT7 a superb instrument to allow oneself to be rearranged - all the way down into the core - into a coherent, harmonious, well-integrated, peaceful, loving and ecstatic human being. And all that in such a gentle and peaceful way. The right dosage seems to be important. (e.g. 30mg/150lb) It's a great material for inner work: deep, patient, kind! And then the bliss...
-Andrea van de Loo (medicine woman)

I am a social worker who works with mentally ill people. On this day, I was accompanying them to the theme park for the day. ... the day in the park was a very connective experience, in that my emotional tie to my clients (the patients) seemed to be strengthened by the openess that I was feeling towards them. I felt very understanding of their problems and free to disclose my own problems in comparison. Now, I already got along great with the clients (they affectionately refer to me as 'The Head Client'). The 2CT7 just shed some light on the fact that people are people, irregardless if they are nutz or not. We're all nutz in some way.
-Catfish Rivers, 25mg orally

I have benefitted GREATLY from the 2c-t-7 experience. It seemed to "cure" a case of low-grade depression that I have been experience for nearly a year now. Depression that developed as a result of some complex issues in my life. I was able to gain significant insite regarding these issues as by using 2c-t-7 as a tool for exploration. As a matter of fact, I landed in such a good place after the last trip, I have been hesitant to use 2C-T-7 again, because dont know if it will drop me back down in this same place.
-Doctor

I was one with the universe. it was great dancing in the rain and jumping in puddles. probably one of the greatest experiences ive encountered in my life.
-Freedom, 25-30mg orally

My 2C-T-7 experience inutterably surpassed my wildest expectations: it's the closest i've ever come to religon. 2C-T-7 opens the gateway to another world where all senses are one, and where the mind can do ANYTHING. 100% the most amazingly beautiful 8 hours i have ever lived.
-Kurt, 30mg orally

Extremely spiritual drug. At one point in the evening I felt as if my body dissolved and I became the music. Often I would melt into the things I was leaning on (eg. the walls, a refrigerator) in a fun way. Make sure you have reassuring friends around as it is very easy to become scared.
-loser37

I had just broken up with my girlfriend of the past six years. Without a doubt, that has been one of the most difficult experiences of my life. Before this trip, I have not been able to except in my mind that our relationship was truly over. My self esteem was as low as could be and I doubted I could carry on with another relationship. This trip allowed me to let go of her and accept that what we once had was over. At the peak, I cried, or rather wailed, for us and what we had. This release of emotion was so intense it was like giving birth. ... Since coming out of this trip, I feel better about myself that ever, and I have a new confidence in me that has not been there for quite a while. It is hard to say exactly what is different, but so much is because of the 2C-T-7. The changes produced go far beyond what I am now mentioning, but I have not had time to integrate all that has happened to me. I just know that my life is truly different now. A true near-death experience. I also quit smoking because of the trip!
-MGSeeds, 50mg orally

Greater appreciation for nature was experienced. There was also a great sense of inner peace attained as my feelings towards others were slightly negative, in other words I preferred solitarity to being around large groups.
-Mo

What a wonderful substance! It is possibly one of the easiest psychedelics to handle as far as the mental aspect is concerned. It produces very little 'trip' compared to the major psychedelics (LSD, Mescal, Psilocybin). No pronounced ego-splitting, time dilation is minimal, visuals are non-threatening and do not carry much meaning. This drug is not terribly insightful, but it does wonders for seeing the humor in all things. Initiates to psychedelic drugs handle it wonderfully, except for the duration. The drug allows you to retain mental control while still enjoying a myriad of fascinating visual, aural, and somatic effects. I find the drug to be more pleasurable than MDMA, giving a full body rush for an incredible length of time. It makes music sound better than anything. Lots of laughing, singing and lounging around. Let's keep it legal! Please!?!
-MrGoodTrips

My main experience was feeling like my skin was several inches thicker. I was much more in tune with my chi and that of others.
-osi

I tripped with a few friends on 2-c-t-7 while jamming in a basement. I had done the drug twice before and they had not. After a few hours of rough starts and stops, beer breaks and what not, we started to feel each others groove. Now jamming has inherintly some aspects of telepathy, especially when improvising. But we hooked up on some sounds that were absolutely out of this world. After we nearly collapsed from psychic strain we all related similar tales of "seeing the music" and being led along a path by "merry elementals". ... Playing while high on 2C-T-7 has had a lasting effect on my psychedelic approach to improvisational jamming.
-Red Lizard, unspecified dose

I have ingested almost 2 grams of 2CT7 over a 7 month period. I settled into a daily +1 museum dosage of 5-10mg 2CT7. This is something I do with many psychedelic drugs since I use them as therapeutic agents. There is a significant [phenethylamine] hangover from the compound as well as a consistent result from each dose. It was difficult to stop taking 2CT7 and I used a SSRI to regain seratonin balance. I found it to be one of the most powerful cognition enhancers I've ever encountered.
-swifty

I have a feeling that this could be a very useful material for enhancing creativity; the mindspace is novel and open enough to be quite inspiring, without impairing one's ability to express the results of such inspiration. I find 2C-B to be very effective in this regard as well. 2C-T-7, however, gives you considerably more time in the state (nearly twice). I also believe that it could be an extremely helpful ally for the shamanically oriented psychotherapist, allowing the patient an incredibly lucid, positive, comfortable mindspace in which to reflect without the marked physical side effects of MDMA or the sometimes threatening intensity of an ego-dissolving LSD session.
-Trey, 20mg orally

I got angry/short-tempered without any good reason during both my two sessions, and this is not normal for me.
-wolf

Negative Results

Suffice it to say that at 125mg/110lbs the effects were unpleasant but bearable. My partner and I threw up several times and for a couple hours the visions could be described as "toxic", but the overall trip lasted about 12 hours as usual, and by the halfway point we were coming down normally. We felt surprisingly functional in mind, body and spirit the following day. Also, after we had come down substantially the effects were quite pleasant for me and I had a unique opportunity to integrate some of the darkest visions with some of the most awe-inspiring, giving me some insight into their balance. My partner says she was not so able to integrate the experience, because it was too overwhelming. We were very fortunate to have a close friend who was able to be with us within minutes after calling her. She was very good at reminding us to breathe and find our center. The hallucinations were so intense that it was difficult to see, let alone make eye contact, have a conversation, or attempt to move or manipulate objects. However, my internal landscape, although complex, was coherent and meaningful. I can think of no other entheogen I have personally encountered that can be taken an order of magnitude beyond "recommended" dosage with so few negative physical effects. The dosage we took was unintentional, but in the end we were able to laugh about it and agree that at the proper dosage 2ct7 could be quite useful. We had been complaining that we were "getting old" and never did such things anymore, and in our rush to re-enter the entheogenic realm, we made the kind of careless mistake "mere novices" tend to make. Proof that no matter how much we "know" we are still not infallible. ... While this was certainly a ++++ for me, I'm not sure I could convey the contents clearly enough to emphasize the transcendental aspect of the trip. As far as my girlfriend is concerned, there was no transcendental aspect of this trip, we were merely crazy and/or stupid. Again, I intend to try 2ct7 again at the proper dose for a basis of comparison, and I'm hoping I can write something intelligent and revealing after that.
-Anonymous, 125mg orally (accidentally taken after the scale was misread as 12.5mg)

The worst experience of my life. Demons, devils, and all negative experiences. Spent 2 months seeing a psychologist due to post traumatic stress syndrome.
-Anonymous

Did a reasonable well measured ammount at burningman. Felt nothing for an hour or two. Was walking constantly durring this time. Then felt like I had to take an emmergency shit. Turns out I had a ton of gas instead followed by dry heaves. Totally sick. Struggled across the playa to my camp (with some rather pleasent visuals that I was unfortunately not in the frame of mind to appreciate). Layed there feeling nasty and quasi delerious. After an hour or two, got up feeling fine and went on with my night.
-automaton23

The last time I tripped I took way too much and it was so dissciative, I couldn't walk, talk, focus, see... pretty much anything, I wasn't sure if I was alive or not. It wasn't scary but it wasn't a good thing either. I think I will take a break because I've been using it a lot. I'm ok on the come down if I'm with people, but when alone I get pretty depressed on the initial comedown.
-Buffy

Last week I snorted 30mg of 2ct7... This was stupid. I guess it is equal to around 150mg orally the physical effects were too much, in the end I decided i had overdosed and would die. I lay on the floor in my vomit and gave up my body. Once I did this I was shot into a variety of hyperspatial planes, some the same as I visit on dmt or shrooms. Here I was taught many things about myself, time, language and energy. Awesome but I felt lonely and worried for my friends who would have to deal with my death. course, I returned to my body but felt that the 2ct7 had done some real physical damage to my brain, I couldn`t move, see or hear properly. This was pretty upsetting and I called a friend to come over and help me, making that phone call was about the most difficult task I have ever done. The voices didn`t stop until saturday night, 2 days later. I still keep getting tremors of energy rising from my feet and terminating in the center of my brain.
-crow, 30mg insufflated

It seems like a shoddy version of 2C-B, not as clean feeling.
-daoistraver

The burn was THE most intense pain I have ever experienced from snorting powders and I have snorted some painful stuff ... This stuff throroughly burnt my nose and my throat. Then the taste from the drip was absolutely awful! ... Within five minutes of snorting, it came on hard and fast. I was getting visuals even as I frantically dripped water in my nose. Fifteen minutes later the nasty taste and the terrible burn surged through my head again as I VIOLENTLY puked through both my mouth and my NOSE. I was alternately hot and cold. I expected the mad visuals but I did not expect the strong vibrations, which rattled up through my legs. While the visuals were better than any other psychedelic, I could not enjoy them. Every time I started to trip on them my heart would started pounding really hard. In fact, my heart hurt all throughout the trip and was sore for 24 hours afterwards. I was seriously worried that I might have a heart attack and I believe that I would have one at higher doses. Another difference between this trip and my oral experience was the effects on my mind. My mind was totally dissolved and I experienced complex hallucinations. For example, I thought that I had jumped out my window, then I told myself "Wait! That's a hallucination. I'm standing outside the house," then I thought "Wait! That's a hallucination. I'm looking out my window," finally I realized that I was still in bed and I frantically congratulated myself for not REALLY jumping out my window.Besides the vibrations, mind dissolution, and heart problems, the other suprising aspect was the auditory hallucinations. My hearing was ten times more sensitive then usual. Activity outside sounded like it was right in the room with me. I kept turning down my music because it was overwhelmingly loud. The next day I turned on my stereo and tried to listen to music at the volume that I had set during my trip. I could barely hear the music; I had it turned almost all the way down!!!! Music was also VERY distorted during my trip. Singers sounded very different and the tempo was a lot faster than normal. After trying different types of music it was finally too much and I turned off my stereo. Yet even the quiet room was noisy! I began to hear a ringing in my ears which morphed into different music and voices. If my account of the wild visuals sound fun, don't be fooled; it was really not worth it.
-HeWhoLives, 15mg insufflated

I think that it would have been a really enjoyable experience if my dose was smaller. I did not have a *bad* time necessarily, it was just a bit more than I was anticipating. I would do it again.
-Kaya, 15mg orally

I had a very bad reaction; pill started to work 2.5-3.5 hours after I ingested [it]. Feelings of sickness (nausea, weekness, loss of dexterity and control of hands and tremors) set in 30 [minutes] before the visuals set in. Feelings of sickness lasted about 7 hours along with extreme [exhaustion] and feelings of loss of consciousness, although I'm told I remained responsive. All in all the trip lasted around 14 hours with a slow come down similar to that of meth.
-Kim, 10mg orally

I was propelled into 6 hours of self-sentenced hell, a state of torture through overexcitation of the sensory channels. This was a brutal, relentless assault on the senses. Visuals?? Try near blindess from visual distortion. Sounds being distorted into echoing, chirping aural hallucinations. It was way too much to take. It was as effective a torture as if someone had hooked a mild electric current to my brain stem and turned on the power. Only a seasoned vet could hold on through this. I could easily see other less hardened folks calling 911. And mind you, it was tempting, if only because of the sedative injection that I knew could bring me down. As it was, I only had a bottle of honey liqeuer (70 proof) to help me but you better believe I ran to that fucker. Alcohol suddenly became a medicine, an anaesthetic to deliver me from the torture. There I was, trying to calculate in my severely confused state how much I could drink to knock me out but not kill me. Meanwhile I almost couldn't even see the bottle, the visual distortion was so blinding. Eventually the alcohol began to wash over and dull the 2C-Torture, but then it would come back in angry waves, overwhelming the alcohol, prompting me to take more anguished swigs. Oh what I would have given for something that would have knocked me out.
-Methyl Man, 35mg orally

For me it has an evil side, brings out unpleasant thoughts and feelings, makes everything look weird in a bad way. I expected outrageous visuals and euphoria, and all i got was patterns, body tremors and paranoia.
-nailz

Snorting is not the best way to go, it hurts really bad and the transition from completely sober to heavily hallucinating is not an easy one to make in five minutes with intense nasal pain.
-Siwwygoff

My first 2ct7 experience was an overdose. I insuffalated approximately 20mg and was sent into delerium. My body felt like it was being torn apart from the inside, and my temperature regulation was out of whack. I closed my eyes and removed my clothing to escape all sensory input and was then thrown into a world of cartoonish CEVs. I have never encountered such engrossing CEVs on dextromethorphan before. This lasted for 2 hours. For the first hour I had "The Fear". Many of my CEVs involved people being found postmortum having died of drug overdoses. During this time I felt as if I were experiencing every awful emotion that one can experience, and the psychological and physical pain was intense. I felt as if my ego had been demolished, but not in the usual sense of "Who am I?" but in the sense of "I am shit, I am no better than anyone else, I am not unique." This does not sound as bad as it really was; it was one of the more psychologically painful experiences in my life. The second hour of delerious CEVs was much less painful. It was during this hour that my ego was rebuilt. I embarked on a bit of a "vision quest", but I never exactly had a sense of OOBEness, I was more of an observer. I travelled through space and time and observed many things including quite a few Southwestern United States landscapes and Native Americans ingesting peyote. All of these visuals were very cartoonish. After this I slowly began to come out of the delerium and was able to open my eyes again, after which I had a normal, albeit intense, 2ct7 trip going. The overdose was a very negative experience but also a very positive one as well. I would not wish to repeat it again simpley because I feel that I may have been in physical danger, because of the physical pain I felt and the temperature regulation problems.
-Yossarian, 20mg insufflated

Drug Combinations

I have smoked 5MeODMT while on 2C-T-7, and found the mix to be contrary. That is, the substances seem to be antithetical to one another. It doesn't leave you much room for insight.
-Candyass

I usually took 1 2CT7 [ed.: as Blue Mystic tablets] on the come down of a roll, so 3-4 hours after i took E. It has wired effect. Strong halucinations, everything looks like a van Gogh painting, intensive body sensations, extremly horny, sometimes permanent contractions of stomach muscles. Sex is unbelievable intensive and extremly wild (with my partner being on the same combo, that is). Sleeping problems afterwards, usually mild/medium headache the next day, but no stronger depressive/down feeling than only E nights.
-E

2C-T-7 is NO EXCEPTION to the enhancing wonderfullness of marijuana: marijuana can send you back into the visuals after you have begun to come down, each hit is a power pill of visuals.
-Kurt

Back into a meditative posture... more light. No aliens, insectoid thought probes, little clowns, there was only pure radiant light. It started from a single point, then flaring out and enveloping me whole. Warmth, pure radiating white, pulsating heat. Physically I feel alive, warm, energetic, happy. Somewhere in there I lost myself and became the light. Maybe I merged with it, maybe I was the light all along, but the perception of the light being something other than me ended, and I was light. Bursts of warm energy bombard me from all sides, a shower of raw energy. ... One primary idea that was present throughout the entire voyage was the need to do things mindfully. If you are not consciously aware of each and every action you make, you are basically sleeping. Every breath, step, keystroke, thought, word, and deed should be the result of a conscious decision, not a subconscious reaction... think about it.
-Occupant, 15mg 2C-T-7 insufflated with 100mg ketamine and 3 grams Psilocybe mushrooms

Aftereffects

Mild depression and anxiety somewhat similar to the day after an acid trip in my opinion.
-Abbadon

[I] felt worn out the day after... was still able to function, but only a t about 70% [efficiency].
-Anonymous

Improved mental agility - vocabulary range seemed to widen, less like to say 'erm...' between words of a conversation.
-Anonymous

The effects continue on a very empathetic level. I can place myself in anothers position and understand them on an emotionally level.
-Anonymous

A mildy positive afterglow seems to occur for the first few days following. I've noticed some lethargy on the day following a high dose, but I would probably attribute this to the lack of sleep rather than directly to the 2C-T-7.
-Anonymous

Sporadic mild waves of 'complicated' nausea, combined with chilled sweats, perhaps every 6hrs, lasting about 2 and a half days. Loss of appetite concomitant with presence of nausea.
-BigTrancer

Your mind is sharper than the day after other unmentioned drugs, however your body hates you for the abuse of staying awake for so damn long.
-Bleu

I felt unable to think completely straight or concentrate deeply for about 24-48 hours afterward.
-bzwax

Diarrhea once lasted 2 days afterwards.
-Catfish Rivers

The main side effect that I had noticed were problems with memory for approximately a week after.
-Crazyfish

Visuals are slightly noticeable for about 48 hours after dosing. Pleasant mood and outlook on life for about the same period.
-DJ Furby

Next day tends to be a bit tired-but-happy and a slight positive mood shift can linger for some time.
-FlipOut

Very happy and motivated the following day.. everything still seems more vibrant than usual.
-Helios

I had pretty severe anxiety for a week. This is most likely due to the bad half of the trip. Also, I couldn't eat for a while afterwards... I fasted from a Friday night until Sunday morning and felt VERY bad on Sunday (the trip was sat. night) and couldn't really eat on Sunday.
-homeboyJim

The morning afterwards I found myself extreamly dehydrated, even though I had been drinking water all night. Everything remained fuzzy and lack-luster the day after, but this did not take away from the very positive feelings that I brought out of the experiance.
-Johnny B.

This is the only psychedelic which has left me feeling profound goodness long after the experience.
-jungleboogie

In some ways comparable to acid afterglow (but without the negative side effects), and in some ways comparable to mdma afterglow (but more colorful).
-JZ

Feel refreshed and active the next day.
-Krash

I was extremely fatigued for almost a week after use...i have not expirienced fatigue this dramatic from the use of any other drug.
-loraxxx

I'm aware that i've been thru an intense psychedelic experience that was worth all of the uncomfortable things I had to go through (i.e. the nausia and "nose burning").
-lurker

I usually feel depression/anxiety free for up to a week or so.
-Mao

After doing 2ct7 several times I now have a permanent ability to see auras. Generally makes me feel like I'm on a higher level of thinking after usage. Gives me more empathy towards people. I feel more social.
-Marc Holdger

Tend to feel exhuasted afterword, usually into the next day. Some muscle stiffness and soreness.
-Mattbear

After the trip, I continue to feel warm and gooey inside until I sleep. The next day I feel happy, relaxed, but my muscles are a little sore.
-MrGoodTrips

One night, 40mg was taken in a gelcap. After waiting for 6 hours with no noticable effects, I went to sleep. Woke up 8 hours later to intense hallucinations (bright white, primatic colors, patterns) extremely nauseous and vomited explosively. haven't had a similar experience since, after using it several more times
-OTC Shaman

I have not noticed any [aftereffects], on the contrary I feel much clearer the next day than with other psycadelics.
-Paul

Felt a bit sleepy & worn out, but that passed on quickly.
-Psychedelic-Me

The second time I tried 2C-T-7, the residual hangover effect was probably more psychological than physical for me because of the hellish nature of the second trip - I was extremely depressed & felt very disconnected spiritually, as well as finding myself totally incapable of interacting socially in any normal fashion.
-stardarq

No residual effects what-so-ever to my dismay. Usually, when doing a psychedelic drug I see trails after smoking large quantities of cannibis for at least a week to ten days, but with 2c-t-7----NOTHING...!@?
-Trypping Billy

The first ahrd trip i had on 2ct7, the next day was blissful. I was very alert, body felt loose and relaxed and I felt 100% good. On another instance the day after I was semi groggy, a litle stiff in the joints and in my back.
-tss

I had very vivid dreams the following day and my memory seems slightly more in focus - especially of events from many years ago. It also seemed to lighten my mood for a few days.
-Umbra

Strong energy for several days after unlike many other substances.
-Vin

Long Term Effects

The spark of creativity has lasted quite a bit... We're putting everything into action that we talked about when tripping... whereas with other drugs (like MDMA) we talk the talk, but dont walk the walk.
-Anonymous

I have completely and permanently forgotten important pieces of information that I thought I knew by heart (Credit card pin number, etc...)
-Blairistic

Have resolved relationship problems under the influence. Increased [spirituality]. Inspired artistically by the unique visual character. Helped me grieve for the death of my 18 year old dog, great empathogen.
-Catfish Rivers

It seems to have no long term effects when used in moderation.
-Court Jester

I experienced memory disturbances for longer then a week.
-Crazyfish

I didn't have any bad side effects, but two girls that took the same dose with me got their periods messed up after using 2C-T-7. I think this is worth mentioning since I haven't heard this happen with any other drug.
-CuteBoy

I learned alot about myself and the way that I do things. It has helped me to see through my normal barriers and realize/admit to myself things that I needed to do.
-Daturing

I feel that I have more insight regarding many of the major problems that I have been facing in life. also, my last experiment was 2 or 3 weeks ago and I am some vary minor flashbacks and vivid dreams resembling the 2c-t7 experience.
-Doctor

Meditation has now become much easier and more insighful. Can sometimes reach a "tripping" or "flashback" state with quiet concentration.
-Dr. Oculon

I don't know if I've had any long-term effects yet, but I would guess no... with the possible exception of just having a very positive experience and being happy about it.
-Euphony

Can still see minor visuals (especially under influence of marijuana) for weeks after use. Increased my tolerance for LSD. A desire to succeed! Strong urge to be more giving to mankind. Went out and volunteered a week after using!
-Jellymaze

Possibly has placed me in a better mood as I seem to notice irony in things that I may have missed before.
-Joe Don Baker

I'm sure it has damaged my brain/body in some way (as all drugs do). But there is no way for me to know what has been done to me, and I'm not into that spiritual hoopla.
-John

Vision is affected for a long long time. I took 2ct7 on saturday and sunday: its now monday and things still look 'off,' psychedlic, as it does in the last hour of an acid trip. Lights are brighter, contrast in increased, things are more colorful, and there is a lot more motion. Trees are so very beautiful all the time now -- they don't look the same as they did before I started on this drug. Also, the drug seems to have a very long afterglow, in the range of 2-3 days.
-jpx

A week after taking it, i still felt a mild afterglow, but i get the same thing from MDMA and LSD.
-JZ

Myself and others have noticed that, within two or three weeks of using 2CT7, muscle twitches of varying degree become apparent. I believe this substance is probably HIGHLY NEUROTOXIC. With large doses or frequent use, neurological symptoms become more severe. Reported symptoms include: ringing in the ears/"tinitis" like symptoms, muscle twitches, numbness in the extremities, pins and needles etc. Symptoms of cognitive damage are also reported. Impaired memory, especially difficulty in remembering simple things they had never previously had difficulty with, such as telephone numbers or the spelling of frequently used words.
-labrat

Seems to dramatically help me with my Obssesive Compulsive Disorder for at least a week after.
-Miranda

Colors appear brighter outdoors. Increased feelings (positive) to nature. Trees, plants, and sunsets especially. Nature appears slightly altered...ie...bark waves delicately on trees, the sun and stars are significantly more radiant. Changes appear to be extremely long lasting...if not permanent.
-Mo

The insights poured out of my heart & mind, self-confidence, I really believed that I will be something one day =) and I will ;)
-Mr. Im-Doing-Fine

I feel that 2ct7 comes and leaves my body very quickly. It is a relatively clean drug.
-MrGoodTrips

I gained lasting insight into several interpersonal problems I was at the time unable to get my head around, and renewed several dormant but valuable relationships in response to a reawakened desire to talk to old friends. I was inspired to create some original artworks, which I have not otherwise done since college. I also experienced spontaneous remission from depression lasting approximately 2 weeks.
-Rev. St. Majoon O'Leary, LDD

I would say that the side affects have been both beneficial, and slightly disturbing. I would say that I now have a better outlook on life, however, I still notice visual perception changes that make me wonder if I have somehow damaged myself. At night lights still seem brighter than they should be, and colors definitely seem brighter. I don't really mind these side affect, but it seems like they should have gone away by now.
-RG

I feel as though my use of 2c-t-7 has effected my thought processes in general. While under its influence, the fashion which I think is very unique... but these patterns have drifted over into my sober life. The condition is best described as arriving at conclusions without thinking about a thing. Almost as though completing a thought is a reflex, and no longer a process.
-señor coconut

Sharpened long distance vision still there after almost two weeks! Positive effect!
-Sir Robin

Both times I've tripped on 2C-T-7 I have learned a lot. The first trip was partially difficult, but mostly just astounding & the second trip was indescribably horrifying - but I came away from both experiences with a wealth of knowledge I wouldnt have gotten any other way.
-stardarq

The introspective and emotionally beneficial aspects of 2CT7 have allowed me to develop and appreciate my relationships with people. 2CT7 has also helped to remove personal obstacles that have prohibited progress in my life.
-swifty

I am reminded of what is primarily important in my life, which is family friends and my spirituality.
-Toronto

It definitely changes the way you look at yourself as well as other people and people in general. Similar to the first time I tried MDMA, the feelings and thoughts I had following the first 2ct7 trip were very intense and positive, allowing me to look at the grander scheme of things.
-tss
 


User Quotes 2C-T-2 vs. 2C-T-7




I found 2C-T-2 to be nothing at all like 2C-T-7. It has an all together different nature. ... 2C-T-2 hits you hard and fast. 2C-T-7 has a long and slow come up, yet they both peak by the three-hour point. ... 2C-T-2 is not a very visual psychedelic. I had very nice visuals, don't get me wrong, but NOTHING at all like I would on 2C-T-7. ... I was very nauseous in the beginning [of the 2C-T-2 trip], more so than with 2C-T-7 ... It is definitely stronger on a milligram per milligram basis compared to 2C-T-7, as 20 mg of 2C-T-7 would not have been that strong. 2C-T-2 seemed to do little to the music. Again, this is not 2C-T-7. To me, it was more of an introspective head-trip, rather than the mind candy effects of 2C-T-7. I was lost in internal thought, rather than becoming enthralled with the outside world. I disagree with an Internet posting that stated 2C-T-2 is a wannabe 2C-T-7. ... I never experienced any of the body-load that 2C-T-2 has been accused of producing. In fact, it much easier on my body than 2C-T-7 ever has been. ... If you want mind-blowing visuals like those produced by 2C-T-7, this is not your drug. But for an introspective journey with a somewhat short duration and a non-threatening nature, this is the chemical for you.
-morninggloryseed

The visual aspect [of 2C-T-7] was nice, but less pronounced than the visuals from 2C-T-2 or mescaline. The physical body high was similar to mescaline, and quite enjoyable... except towards the end I felt some uncomfortable neck and shoulder muscle tension similar to the phenomenon one of Shulgins associates in PiHKAL described as the 'MDA cloak'. During the peak, I noticed extreme time dilation, similar to 2C-T-2. I also noticed some very extreme aphrodisiac effects during the first hour or so of the trip. This material also doesn't seem to kill the appetite, and I found making and eating a meal after the peak to be an incredible experience. From the time I ate the drug until I was able to fall asleep was around 9 hours. I found the trip to be comparable to 20mg of 2C-T-2, although there are very significant differences between the two. ... Its interesting that I'm unusually sensitive to 2C-T-7, though I show no unusual sensitivity to 2C-T-2. Just goes to show that you cant make assumptions one one drug based on another, no matter how similar they may be.
-Murple

Kind of similar to T-7, more distortion, less warmth. With T-7 there is a gentle contentment that is not present here. This is more like the apathy of LSD. The visuals are not the smooth waves of color I get from T-7, but more a fragmentation and 3-dimensional layering with similar refraction. There is no nausea as with T-7 liftoff.
-Ouro

It seemed to me, after later getting a chance to try 2ct7, that 2ct2 was a 'wannabe' version of 2ct7, only without quite as much good clean fun buried within it, and for me at least, a significantly higher body load.
-Scotto
 


2C-T-2 Synthesis




Taken from PIHKAL by Alexander Shulgin

To a solution of 165 g 1,4-dimethoxybenzene in 1 L of CH2Cl2, in a well ventilated place and well stirred, there was cautiously added 300 mL chlorosulfonic acid. With about half the acid chloride added, there was a vigorous evolution of HCl gas and the generation of a lot of solids. As the addition was continued, these redissolved to form a clear, dark green solution. Towards the end of the addition, some solids were again formed. When everything was stable, there was added 2 L H2O, a few mL at a time, commensurate with the vigor of the reaction. The two phases were separated, and the aqueous phase extracted with 2x75 mL CH2Cl2. The original organic phase and the extracts were combined and the solvent removed under vacuum. The residue weighed 162 g and was quite pure 2,5-dimethoxybenzenesulfonyl chloride, a yellow crystalline solid with a mp of 115-117 °C. It need not be further purified for the next step, and it appears to be stable on storage. The sulfonamide, from this acid chloride and ammonium hydroxide, gave white crystals from EtOH, with a mp of 147.5-148.5 °C.

The following reaction is also a very vigorous one and must be performed in a well ventilated place. To a solution of 400 mL 25% H2SO4 (V/V) in a beaker at least 2 L in size, there was added 54 g of 2,5-dimethoxybenzenesulfonyl chloride, and the mixture was heated on a steam bath. The yellow crystals of the acid chloride floated on the surface of the aqueous layer. There should be 80 g of zinc dust at hand. A small amount of Zn dust was placed at one spot on the surface of this chapeau. With occasional stirring with a glass rod, the temperature was allowed to rise. At about 60 or 70 °C an exothermic reaction took place at the spot where the zinc was placed. Additional dollups of zinc were added, and each small exothermic reaction site was spread about with the glass stirring rod. Finally, the reaction spread to the entire solid surface layer, with a melting of the acid chloride and an apparent boiling at the H2O surface. The remainder of the 80 g of zinc dust was added as fast as the size of the reaction container would allow. After things subsided again, the heating was continued for 1 h on the steam bath. After the reaction mixture had cooled to room temperature, it was filtered through paper in a Buchner funnel, and the residual metal washed with 100 mL CH2Cl2. The two-phase filtrate was separated, and the lower, aqueous phase was extracted with 2x75 mL CH2Cl2. The addition of 2 L H2O to the aqueous phase now made it the upper phase in extraction, and this was again extracted with 2x75 mL CH2Cl2. The organic extracts were pooled (H2O washing is more trouble than it is worth) and the solvent removed under vacuum. The light amber residue (30.0 g) was distilled at 70-80 °C at 0.3 mm/Hg to yield 25.3 g 2,5-dimethoxythiophenol as a white oil. This chemical is certainly not centrally active, but it is a most valuable precursor to all members of the 2C-T family.

To a solution of 3.4 g of KOH pellets in 75 mL boiling EtOH, there was added a solution of 10.0 g 2,5-dimethoxythiophenol in 60 mL EtOH followed by 10.9 g ethyl bromide. The reaction was exothermic with the immediate deposition of white solids. This was heated on the steam bath for 1.5 h, added to 1 L H2O, acidified with HCl, and extracted with 3x100 mL CH2Cl2. The pooled extracts were washed with 100 mL of 5% NaOH, and the solvent removed under vacuum. The residue was 2,5-dimethoxyphenyl ethyl sulfide which was a pale amber oil, weighed about 10 g and which was sufficiently pure for use in the next reaction without a distillation step.

A mixture of 19.2 POCl3 and 18.0 g N-methylformanilide was heated briefly on the steam bath. To this claret-colored solution there was added the above 2,5-dimethoxyphenyl ethyl sulfide, and the mixture heated an additional 20 min on the steam bath. This was then added to 500 mL of well-stirred warm H2O (pre-heated to 55 °C) and the stirring continued for 1.5 h by which time the oily phase had completely solidified to a brown sugar-like consistency. The solids were removed by filtration, and washed with additional H2O. After being sucked as dry as possible, these solids were dissolved in 50 mL boiling MeOH which, after cooling in an ice-bath, deposited almost-white crystals of 2,5-dimethoxy-4-(ethylthio)-benzaldehyde. After filtration, modest washing with cold MeOH, and air drying to constant weight, there was obtained 11.0 g of product with a mp of 86-88 °C. Recrystallization of a small sample again from MeOH provided an analytical sample with mp 87-88 °C. Anal. (C11H14O3S) C,H.

To a solution of 11.0 g 2,5-dimethoxy-4-(ethylthio)benzaldehyde in 100 g of nitromethane there was added 0.5 g of anhydrous ammonium acetate, and the mixture was heated on the steam bath for 80 min (this reaction progress must be monitored by TLC, to determine the point at which the starting aldehyde has been consumed). The excess nitromethane was removed under vacuum leaving a residue that spontaneously set to orange-red crystals. These were scraped out to provide 12.9 g crude 2,5-dimethoxy-4-ethylthio-beta-nitrostyrene with a mp of 152-154 °C. A sample recrystallized from toluene was pumpkin colored and had a mp of 148-149 °C. Another sample from acetone melted at 149 °C sharp, and was light orange. From IPA came spectacular fluorescent orange crystals, with a mp 151-152 °C. Anal. (C12H15NO4S) C,H.

A suspension of 12.4 g LAH in 500 mL anhydrous THF was stirred under He. To this there was added 12.4 g 2,5-dimethoxy-4-ethylthio-beta-nitrostyrene in a little THF, and the mixture was held at reflux for 24 h. After the reaction mixture had returned to room temperature, the excess hydride was destroyed by the cautious addition of 60 mL IPA, followed by 20 mL of 5% NaOH followed, in turn, by sufficient H2O to give a white granular character to the oxides. The reaction mixture was filtered, and the filter cake washed first with THF and then with MeOH. Removing the solvents from the combined filtrate and washings under vacuum provided 9.5 g of a yellow oil. This was added to 1 L dilute HCl and washed with 2x100 mL CH2Cl2 which removed all color. After making the aqueous phase basic with 25% NaOH, it was extracted with 3x100 mL CH2Cl2, the extracts pooled, and the solvent removed under vacuum to provide 7.3 g of a pale amber oil. Distillation at 120-130 °C at 0.3 mm/Hg gave 6.17 g of a clear white oil. This was dissolved in 80 mL IPA and neutralized with concentrated HCl, forming immediate crystals of 2,5-dimethoxy-4-ethylthiophenethylamine hydrochloride (2C-T-2). An equal volume of anhydrous Et2O was added and, after complete grinding and mixing, the salt was removed by filtration, washed with Et2O, and air dried to constant weight. The resulting white crystals weighed 6.2 g. 

 

 


2C-T-7 Synthesis




2C-T-7 Synthesis

Taken from PIHKAL by Alexander Shulgin

To a solution of 3.4 g of KOH pellets in 50 mL hot MeOH, there was added a mixture of 6.8 g 2,5-dimethoxythiophenol (see under the recipe for 2C-T-2 for its preparation) and 7.4 g (n)-propylbromide dissolved in 20 mL MeOH. The reaction was exothermic, with the deposition of white solids. This was heated on the steam bath for 0.5 h, added to 800 mL H2O, additional aqueous NaOH added until the pH was basic, and extracted with 3x75 mL CH2Cl2. The pooled extracts were washed with dilute NaOH, and the solvent removed under vacuum. The residue was 2,5-dimethoxyphenyl (n)-propyl sulfide which was obtained as a pale yellow oil, and which weighed 8.9 g. It had a light pleasant fruity smell, and was sufficiently pure for use in the next reaction without distillation.

A mixture of 14.4 g POCl3 and 13.4 g N-methylformanilide was heated for 10 min on the steam bath. To this claret-colored solution was added 8.9 g of 2,5-dimethoxyphenyl (n)-propyl sulfide, and the mixture heated an additional 25 min on the steam bath. This was then added to 800 mL of well-stirred warm H2O (pre-heated to 55 °C) and the stirring continued until the oily phase had completely solidified (about 15 minutes). The resulting brown sugar-like solids were removed by filtration, and washed with additional H2O. After sucking as dry as possible, they were dissolved in an equal weight of boiling MeOH which, after cooling in an ice-bath, deposited pale ivory colored crystals. After filtration, modest washing with cold MeOH, and air drying to constant weight, there was obtained 8.3 g of 2,5-dimethoxy-4-(n-propyl-thio)benzaldehyde with a mp of 73-76 °C. Recrystallization from 2.5 volumes of MeOH provided a white analytical sample with mp 76-77 °C. The NMR spectrum in CDCl3 was textbook perfect, with the two aromatic protons showing singlet signals at 6.81 and 7.27 ppm, giving assurance that the assigned location of the introduced aldehyde group was correct.

To a solution of 4.0 g 2,5-dimethoxy-(n-propylthio)benzaldehyde in 20 g of nitromethane there was added 0.23 g of anhydrous ammonium acetate, and the mixture was heated on the steam bath for 1 h. The clear orange solution was decanted from some insoluble material and the excess nitromethane removed under vacuum. The orange-yellow crystalline material that remained was crystallized from 70 mL boiling IPA which, on slow cooling, deposited 2,5-dimethoxy-beta-nitro-4-(n)-propylthiostyrene as orange crystals. After their removal by filtration and air-drying to constant weight, they weighed 3.6 g, and had a mp of 120-121 °C. Anal. (C13H17NO4S) C,H.

A solution of LAH (132 mL of a 1 M solution in THF) was cooled, under He, to 0 °C with an external ice bath. With good stirring there was added 3.5 mL 100% H2SO4 dropwise, to minimize charring. This was followed by the addition of 8.4 g 2,5-dimethoxy-beta-nitro-4-(n)-propylthiostyrene in 50 mL anhydrous THF. There was an immediate loss of color. After a few min further stirring, the tem-perature was brought up to a gentle reflux on the steam bath, then all was cooled again to 0 °C. The excess hydride was destroyed by the cautious addition of IPA (21 mL required) followed by sufficent 5% NaOH to give a white granular character to the oxides, and to assure that the reaction mixture was basic (15 mL was used). The reaction mixture was filtered and the filter cake washed first with THF and then with IPA. The filtrate and washes were combined and stripped of solvent under vacuum providing about 6 g of a pale amber oil. Without any further purification, this was distilled at 140-150 °C at 0.25 mm/Hg to give 4.8 g of product as a clear white oil. This was dissolved in 25 mL IPA, and neutralized with concentrated HCl forming immediate crystals of the hydrochloride salt in the alcohol solvent. An equal volume of anhydrous Et2O was added, and after complete grinding and mixing, 2,5-dimethoxy-4-(n)-propylthiophenethylamine hydrochloride (2C-T-7) was removed by filtration, Et2O washed, and air dried to constant weight. The resulting spectacular white crystals weighed 5.2 g. 

 

 

 


2C-T-2 Flier




2C-T-2®

2,5-Dimethoxy-4-Ethyliophenethylamine

What is 2C-T-2?

2C-T-2 is a synthetic compound in the "phenethylamine" family of chemicals. 2C-T-2 is a psychedelic amphetamine with two sides: an energetic "speedy" one and a mind-expanding "trippy" one. The "trippy" effect is the dominant one in 2C-T-2.

What does 2C-T-2 do?

2C-T-2 has a consciousness-altering effect. In general, this is described as "tripping" or "hallucination". The user's perception of reality changes, time and space take on a different meaning and emotions - either positive or negative - can be enhanced.

Dosage and use

One tablet of 2C-T-2 contains 8 milligrams of the active substance. 2C-T-2 is sold in sets of two 8mg tablets - a total dose of 16mg.

If you are using 2C-T-2 for the first time, or only want to experience mild effects, take one tablet with a considerable amount of water. It is advisable to have some food in your stomach, so as to retain the water for a time. If you take two tablets (16mg), expect a strong and intense experience. Never take two tablets the first time you use 2C-T-2!!!

Setting

Hallucinogens like 2C-T-2 strengthen the intensity of your senses. Use these substances in a peaceful setting. Outdoors (in a wood or park) or at home are ideal places. Do not take them when you are alone, unless you are an experienced user. Well-chosen music and light, incense and your own positive attitude can heavily influence the effects of the substance, and will intensify the experience. Ensure that you have plenty of water to hand, and a place where you can lie down comfortably.

Warning

Consciousness-changing substances such as 2C-T-2 can have a major effect on your life. In our opinion, their benefit comes from integrating the insights which you gain during your experience into your life. Never underestimate 2C-T-2!

After using 2C-T-2, take good care of your body. A balanced diet and use of the correct vitamins and food supplements will accelerate the recovery of your brain and other organs. Drink plenty of fluids during the days following use, so as to detoxify your body rapidly.
Do not use 2C-T-2 if you:

  • are pregnant or breast-feeding;
  • suffer from depression;
  • are taking mood or consciousness-altering medicines or other drugs;
  • are diabetic;
  • have high or low blood pressure;
  • have a heart or lung disease;
  • have ever had hepatitis A or B or any other liver infection;
  • intend to drive or operate machinery;
  • have drunk alcohol;
  • are younger than 18;
  • are being forced to against your will;

If you are in any doubt do not take the substance, or ask a specialist or doctor for advice!

Increased physical effort whilst using 2C-T-2 can cause nausea and headaches.

Exclusive distributor: Conscious Dreams Distributie bv, Amsterdam, tel. +31 20 470 7744. 

 

 


Blue Mystic Flier, Version One




Blue Mystic (contents per tablet: 7.5 mg PT-DM-PEA) 5 tabs. = 1-2 doses

Dosage:
Women usually need 2-3 tabs for a full dose, while men normally need 4-5 tabs for a full dose. Take the wanted dose in once. Double dosing is not a option because that does not increase the effects. Because about 15% of the people that try this psychedelic, need much less than others, it is very strongly recommended to start with a low dose the first time you try this. Being careful may cause that you miss the boat, but that is better than to take too much. You can work your way up in a different few times to try to find your optimal dose.

General effects & course of the experience:
This is a strong one. The effects can last 8 up to 15 hours. A lot of people compare PT-DM with mescaline for the feeling and visuals that it brings. There are also characteristics of 2CB, LSD (visuals) and MDMA (feelings) involved. The onset usually begins between 30 - 90 minutes after ingestion. For some the onset takes a little bit longer. An energetic / physical dynamic feeling, visual and auditory changes come in. The way up to the peak may be a little bumpy. Approximately 1- 2 hours after the onset the peak experience begins. This can be compared to the peak of mescaline and is often experienced mystical and full of awe. Most find it much easier to navigate than with other psychedelics. Somewhere in the neighborhood of 5 - 6 hours after onset a plateau sets in and will stay for 2,5 - 6,5 hours. This is a long one. But you are able to sleep and eat if desired. The plateau is considered mild but absolutely present. The visuals are subtle and a strong feeling, (a bit MDMA-like) lasts for the rest of the experience. Some experience time dilution. Best synth we know of! Please read the enclosed flight instructions.

Usage:
Take this on an empty stomach / after a very light meal, or otherwise there may be some nausea in the beginning of the experience. Drink enough fluids during the experience to prevent dehydration. If at any time headache may occur during the experience, then solve this by eating and drinking The way you feel and think before the experience is essential for the character of the experience. So, if you don't feel comfortable and well, postpone the use of The Blue Mystic. We strongly advise you to take the trip in a peaceful and relaxed environment: Preferable in the presence of good friends. Blue Mystic is not suited for party's. This is something to take time for. Make sure there are no troubles on your mind.

 


Blue Mystic Flier, Version Two




Blue Mystic

Dosage:
Women usually need 1-2 tabs for a full dose, while men normally need 2-3 tabs for a full dose. Advice for women: Do not take more than 2 tablets within 8 hours. Do not take more than 1 tablets the first time that you try Blue mystic.
Advice for men: Do not take more than 3 tablets in 8 hours. Do not take more than 2 tablets the first time that you try blue mystic.
Take the wanted dose in once. Double dosing is not a option because that does not increase the effects. Blue Mystic has a steep dose-response curve.
Because about 15% of the people that try this psychedelic, need much less than others, it is very strongly recommended to start with a low dose the first time you try this. Being careful may cause that you miss the boat, but that is better than to take too much. You can work your way up in a different few times to try to find your optimal dose.

General effects & course of the experience:
This is a strong one. The effects can last 8 up to 15 hours. A lot of people compare PT-DM with mescaline for the feeling and visuals that it brings. There are also characteristics of 2CB, LSD (visuals) and MDMA (feelings) involved. The onset usually begins between 30 - 90 minutes after ingestion. For some the onset takes a little bit longer. An energetic / physical dynamic feeling, visual and auditory changes are the keywords here. The way up to the peak may be a little bumpy. Approximately 1- 2 hours after the onset the peak experience begins. This can be compared to the peak of mescaline and is often experienced mystical and full of awe. Most find it much easier to navigate than with other psychedelics. Somewhere in the neighborhood of 5 - 6 hours after onset a plateau sets in and will stay for 2,5 - 6,5 hours. This is a long one. But you are able to sleep and eat if desired. The plateau is considered mild but absolutely present. The visuals are subtle and a strong feeling, (a bit MDMA-like) lasts for the rest of the experience. Some experience time dilution. Best synth we know of!

Usage:
Take this on an empty stomach / after a very light meal, or otherwise there may be some nausea in the beginning of the experience. Drink enough fluids during the experience to prevent dehydration. If at any time headache may occur during the experience, then solve this by eating and drinking
The way you feel and think before the experience is essential for the character of the experience. So, if you don't feel comfortable and well, postpone the use of The Blue Mystic. We strongly advise you to take the trip in a peaceful and relaxed environment: Preferable in the presence of good friends. Blue Mystic is not suited for party's. This is something to take time for. Make sure there are no troubles on your mind. Have an excellent flight....

Warning:
This product is not meant for human consumption outside the Netherlands. Outside Holland it may only be used for research purposes.

This is a dietary supplement en should only be used as such. Always consult your physician before use. Especially un case you are under medical supervision. Do not use in case of hart and vascular diseases, in case of high blood pressure, affection of the thyroid gland and / or the adrenal glands and / or the stomach and / or the urine ways, elarged prostate, diabetes, any psychological problems, in case of the use of MAO-inhibitors and / or medicines and / or alcohol and / or drugs. Do not use in case of pregnancy or nursing.

This product is not intended or suited to be used to cure, relieve, or prevent from any affection, disease, symptom, pain, injury or infirmity of man. This product is not meant or suited to be used to cure, improve or change the functioning of human organs, to diagnose by administration or application to man.. This product is not meant or suited to be used as meant in the Dutch medicine law.

Not intended for persons under the age of 18 years old. Store cool and dry. Store out of reach of children.

Expiry date:12/2002
Contents:3 tablets (1-2 doses)
Ingredients:10mg PT-DM-PEA
195mg calcium carbonate
50mg Microcristalline cellulose
1mg FD&C Blue #1
 

 

 


Blue Mystic Shopkeeper Instructions



Instructies voor verkoop:
Verkoop niet aan minderjarigen, aan mensen waarvan bekend is dat zij een psychische problemen hebben of aan diegenen die buitensporig vaak voor eigen gebruik komen halen. Deze gevallen kunnen problemen opleveren voor winkel en product. Geef elke klant persoonlijke informatie over The Blue Mystic. Informeer naar welke andere middelen en welke doseringen daarvan hij of zij gewend is. Dat kan je een aardig beeld geven van de juiste dosis. Lichaamsgewicht doet bij dosering van Blue Mystic veel minder ter zake, dan bij andere substanties. Van Blue Mystic zijn in verschillende smartshops samples genomen door de politie, om te onderzoeken of dit product legaal is. Het resultaat daarvan was mondelinge goedkeuring van verdere verkoop van dit product.


Instructions for resale:
Do not sell to people under 18, people with known psychological problems, or those who buy exceedingly large amounts for personal use; ignoring cases like this could result in problems for the shop and the product. Make sure each individual client is educated (informed) about 'The Blue Mystic'. Ask about other substances, and dosages they are used to taking. This should be helpful in determining the correct dosage. Body weight is less of a factor with 'The Blue Mystic' compared with other substances. Police have taken samples of 'The Blue Mystic' at several smartshops to determine if it was legal to sell. The result of their tests were verbal approval and continued sale of the product.

 

 


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Created 8/29/2001 22:53:58
Modified 8/29/2001 22:53:58
Leda version 1.4.3