Analgesic Kratom-based "Knock-Out" Pill-
"Myrrh" ~ Commiphora myrrha
"Yellow Hornpoppy" ~ Glaucium flavum
"Blackseed" ~ Nigella sativa
"Neem" ~ Azadirachta indica
"Dan Shen" ~ Salvia miltiorrhiza
"Yan Hu Suo" ~ Corydalis yanhusuo
"White Willow" ~ Salix alba
"Chili pepper" ~ Capsicum species
"Black pepper" ~ Piper nigrum
That shit would knock out even the hardest, hardhead!
The first six, I don't see having too potent of a psychoactive effect, though they would help with the analgesia probably. The last three are just herbs and spices, hardly "knock out" drugs.
Azadirachta indica (Neem) (Meliaceae) – Neem essential oil has been shown to have strong insecticidal, insect repellant, and antibacterial action, as well as exhibiting anxiolytic effects similar to diazepam and analgesic effects moderated through both opioid and non-opioid receptor systems. Neem oil contains a variety of terpenoids including azadiractin, azadirone, epoxyaxadiradione, nimbin, gedunin, azadiradione, deacetylnimbin, 17-hydroxyazadiradione and mahmoodin, which have antibacterial and insecticidal action. Also contains the terpenes cardinene, copaene and humulene, the antibacterial hydrocarbons icosane, docosane, 2-methyltricosane and docosene, and a variety of fatty acids.
Capsicum species (Solonaceae) (Chile pepper) – Capsicum frutescens and other species of capsicum are native to Central and South America and Zanzibar. The fruits are used as a food and as a spice for “hot” chile pepper varieties. Hot chile peppers contain the compound capsaicin which irritates mucosal membrane receptors. This results in a false pain signal coming from these mucosal membranes (no damage actually occurs), and the body responds by increasing the release of endorphins which block the pain signals at opiate receptors. Capsaicin also directly interacts with the vanillin receptor complex which mediates pain signals and is closely linked with opiate receptors. This combination of actions results in the strong analgesic and slight euphoriant effects of hot chile peppers. Capsaicin also induces perspiration and is a stimulant. The chile pepper fruit has also be found to contain the chemicals 1,8-cineole, camphor, carvone, chlorogenic acid and scopoletin, all of which are considered CNS-stimulants, and thujone, which is considered a narcotic, stimulant and hallucinogenic.
Corydalis species (Papaveraceae) – Corydalis is a member of the alkaloid rich Papaveraceae family, and most species are rich in benzoisoquinoline alkaloids. Corydalis species have been used as sedative, narcotic and tranquilizing agents in Chinese medicine. Tetrahydropalmatine, derived from Corydalis yanhuosco, has been shown to be a potent dopamine receptor agonist, and has sedative and narcotic effects. Corydalis is generally considered to be toxic. Corydalis cava and C. solida are listed as hallucinogenic and sedative. C. solida is also listed as a nervine agent, and C. ambigua as a sedative.
Nigella sativa (Ranunculaceae) (Black Cumin) – Listed as a stimulant.
Salix species (Salicaceae) (Willow) – Willow bark contains twelve different salicyclates, making up 1.5-11% of the dry weight of the bark. Salicin, salicortin, tremulacin and 2’-O’acetylsalicortin, as well as aromatic aldehydes (such as vanillin), flavonoids and tannins are found in the bark. Effective as an analgesic and antipyretic agent. Willow bark has also been shown to have a slower, more prolonged effect due to the slow absorption and conversion in the body to more active forms of the natural salicyclates, and to cause less stomach upset, and fewer side-effects. Sali alba, S. gooddingii, S. nigra and S. purpurea are listed as hypnotic and sedative agents. Salix caprea is listed as a stimulant and aphrodisiac.
I might suggest adding a couple plants: Sagebrush (Artemisia species) and garden sage (Salvia officinalis) both have mild analgesic properties, as does mint. Or, this funny one:
Cornus stolonifera (Cornaceae) - Red Osier Dogwood is one of the most potent analgesic plants in my area, and very little researched. Saponins are probably the active agents. The preparation for this plant is to peel the bark and separate the white inner bark (active portion) from the outer bark, just as you would do with willow. For optimal potency harvest in spring after the snow melts or late in the fall season. The inner bark can be smoked, chewed or made into tea.